ワクチン免疫の基礎と臨床 - kachikukansen.org

1 39 Journal of Japanese Society for Clinical Infectious Diseasein Farm Animals 2009 364 0026 6 1111 Toll-like receptor (TLR) NK T B Basic and clinical understandings of vaccine immunity - factors influencing vaccine efficacy - 40 2009 T (antigen presenting cell.)

2 APC) B (naive) T MHC II CD4 T T Th0 CD4 T Th0 T Th0 Th1 CD4 T Th1 Th2 CD4 T Th2 Th1 T IL-12 Th2 Toll T IL-4 CD8 T T CTL T (naive) CD8 T MHC I Th1 IL-2 CD8 T B MHC II Th2 Th2 IL-4 IL-5 B B Th1 Th2 41 Journal of Japanese Society for Clinical Infectious Diseasein Farm Animals 2009 CD8 B

3 CD8 T Basic and clinical understandings of vaccine immunity - factors influencing vaccine efficacy - Th1 42 2009

4 43 Journal of Japanese Society for Clinical Infectious Diseasein Farm Animals 2009 IgA IgG immunity gap immunity gap Basic and clinical understandings of vaccine immunity - factors influencing vaccine efficacy - 44

5 2009 30 C 37 C 39 40 C no responder 45 Journal of Japanese Society for Clinical Infectious Diseasein Farm Animals 2009

6 RNA H5N1 AIDS HIV Basic and clinical understandings of vaccine immunity - factors influencing vaccine efficacy - 46 2009 immunity gap

7 SPF HIV 20 47 Journal of Japanese Society for Clinical Infectious Diseasein Farm Animals 2009 .. 2007.. 2 3 : 1 6.. 2007.. 2 : 15.

8 2007.. : .. 2007.. 2 : 7 15.. 2007.. 1 : 1 .Basic and clinical understandings of vaccine immunity- factors influencing vaccine efficacy -Kenji MotokawaThe Kitasato Institute Research Center for Biologicals 6-111 Arai, Kitamoto, Saitama 364-0026, Japan Basic and clinical understandings of vaccine immunity - factors influencing vaccine efficacy .