강동경희대학교병원 약품정보지 - khnmc.or.kr

1 2015 4 VOL .02 Elocom cream. 15g ( ) Corticoid ( , : HH333) ( ), ( ) : ( : ) ' , , , , , , 134-090 892 [TEL] / ( ) [FAX] / ADR case report Elocom cream. 15g (Mometasone furoate) 1. 2. Mometasone furoate 1mg/g 3. 4. IL-1, IL-6, TNF- ( ) , 5. Corticoid 6. 1 1 7. : (increased by inflammation) : : 8. 1) : ( , ) ( , ), ( ) : , , , , , , , , , , , , , , , , , 2) : 3) : , 9.

2 ( ), . corticoid - - (HPA) , , , corticoid cortisol , cortisol ACTH HPA . 1 2015 4 corticoid HPA , , corticoid corticoid HPA .. 10. , , , , 2 , , , , 2 11. : FDA C : 12. , (1~30 ) 1 1 . , , .. 2 2015 4 Reference 1. 2. Lexicomp Online. Copyright 1978-2015 Lexicomp, Inc.

3 All Rights Reserved; and Tadicherla S, Ross K, Shenefelt D, Topical corticosteroids in dermatology; Journal of Drugs in Dermatology 2009; 12:1093. : ( ) Topical steroid Potency classification Common representative topical steroids Indication I. Superpotent clobetasol propionate cream / oint. halobetasol propionate cream / oint. betamethasone dipropionate oint. Diflucortolone valerate oint. Dermovate oint Clobex shampoo Nerisona oint Alopecia areata Atopic dermatitis Discoid lupus Hyperkeratotic eczema II. Potent betamethasone dipropionate cream fluocinonide deoximetasone gel halcinonide cream mometasone furoate oint. deoximetasone lotion XL1 gel Esperson gel Esperson lotion Lichen planus Lichen sclerosus(skin) Lichen simplex chronicus Nummular eczema III. Upper mid-strength betamethasone dipropionate lotion fluticasone propionate oint.

4 Triamcinolone acetonide oint. halometasone cream Psoriasis Severe hand eczema IV. Mid-strength fluocinolone acetonide oint. mometasone furoate cream / lotion Elocom cream Asteatotic eczema Atopic dermatitis V. Lower mid-strength betamethasone valerate cream prednicarbate cream/ emollient fluocinolone acetonide cream fluticasone propionate cream hydrocortisone butyrate cream Dermatop oint Dermatop soln Lichen sclerosus(vulva) Scabies Severe dermatitis Stasis dermatitis VI. Mild alclometasone dipropionate cream / oint. desonide cream fluocinolone acetonide cream triamcinolone acetonide cream Desowen cream Desowen lotion Dermatitis (diaper) Dermatitis (eyelids) Dermatitis (face) Intertrigo VII. Least potent 1%, hydrocortisone cream / lotion / oint. 1%, hydrocortisone acetate cream / lotion / oint. Lacticare HC lotion LactiCORT cream 1% HEL lotion 1% ( ) 1. 1) Prostaglandin arachidonic acid histamine 2) T 3) 2.

5 3. 1) : Vasoconstrictor assay ( ), Mitotic index suppression method ( ), Atrophogenic potential method ( ) 2) : , , 3) (US, 7 ): 1 (Super Potent)7 (Least Potent) 4) 2page 5) : (Ointment) > (Cream) > (Gel) > (Lotion) > (Solution) 4. 1) 3 2015 4 Special Issue Onit. , , , , , Cream Lotion Soln. , , . , Gel.

6 , (potency) . Highly Responsive Moderately Responsive Least Responsive , , , , , , (Potency) Class V, VI, VII Class III, IV, V Class I, II 2) 3) : Class VI, VII : (Class VI, VII) 4) (Finger Tip Unit, FTU): , ( 5mm ) ( , FTU) 1 : 15g, 30g, 60~90g : 20% ( , 1 = FTU=1% BSA) : 25g (Ref. 4 J Am Acad Dermatol 2006;54(1):1~15 ) 4 2015 4 , , , , , , (Potency) Class VI, VII Class IV, V Class II, III Class I , , , , , 3~6 1 1 1 1~2 2 2 3 3~5 2 3 3 6~10 2 5 4 8 7 7 1 2 Q1.

7 ? 2 . 2 , 3 1 2 .. 5. 1) : : , , , : , , . : , : , : , , : , : : , : , . , 2) - - (Hypothalamus-Pituitary-Adrenal gland, HPA) , ( ) , , , , 6.

8 1) , , , , . 2) , . 3) . 4) . 5) 1 2 , , . 6) 7) . 8) . 9) . 10) 2 . 11) 2 . 12) . 13) , . 14) . 15) . 7. Q&A 5 2015 4 6 2015 4.

9 Q2. ( , ) ? , , , ( ), , , . , . Q3. , , ? . , , . Q4. ? , . 1 1.

10 Q6. ? . , , , . Q7. ? .. Q8. ? ? Reference 1. J Korean Acad Fam Med 2000;21(9):1107~1113 2. British Journal of Dermatology 1998;138:293~6 3. Indian J of Dermatology 2012;57(4): 251~259 4. J Am Acad Dermatol 2006;54(1):1~15 5. , , 2009; 340-346 6. , part3, 2015; 415-417 : ( ), ( ).