浸潤性乳癌におけるKi 67標識率の検討 ─Ki 67は予後因子とな …

1 30, 17 21, 2010. - . Ki 67. - .. Ki-67 . Ki-67 .. HER2 Ki 67 . - 91 .. Novocastra HER2 Ki 67 . - DAKO All 2005 St. gallen red HER2 3+ . 1 Ki 67 300 500 . - . St. gallen . HER2 T1 T2. ER PgR 2 2 NG1 NG2 . Ki 67 - NG3 3 HGI HGII .. 5 . HGIII 3 . 2 ly1 v1 . ly0 v0 2 . ER / PR . 2008 ER PgR 2 . Ki 67 - HER2 0 1 . Ki 67 . - 2 3 3 . 2007 St. gallen . 3 . Ki 67 . - 2 . 2006 1 2010 5 . t .. 30 96 59 . 1 .. 1 2 ; T1 65 .. T2 22 T3 1 T4 3 T1. 18. 1. 3. 17 Ki 67 . - 18. NG1 49 46 . NG2 19 . + 2 . NG3 23 + 3. + 1 91. +IMPC 1 . P . + 1 P 1. 1 4. 91 Ki 67 . - HG1 40 . 2. HG2 30 .. T Ki 67 . - HG3 21 T1 65 91.. T2 26 P . P 91. 5. 65 1% 80% Ki 67 . - T2 26 1% N 59 60% N+ 32 2 91. 2 3 ; NG1 49. 1% 50% NG2 19 5% 35% 5 ; 59 1% . NG3 23 4% 80%.

2 80% 32 1% 80% . NG1 NG2 NG2 NG3 2 . P . NG1 NG3 P 5 6 ; . 45 1% 80% . 3 4 ; HGI 46. 40 1% 25% 1% 80% . HGII 30 1% 80% 2 . HGIII 21 5% . 80% 6 7 ; . HGI HGII HGII HGIII D 68 1% 30% .. P . HGI HGIII P ND 23 5% 80% . 2 . 4 P . 19. 6. 8. Ki 67 . - HER2 Ki 67 . - ly, v 45 HER2 78 ly, v+ 46 HER2 6 HER2 7 91. 91. 7. 9. Ki 67 . - Triple negative Ki 67 . - Hormone ND 23 ER and PR nonTN 76 . Hormone D 68 ER , PR , HER2 15. TN ER+ and/or PR+ . 91. 91.. P P D : dependent, ND : non - dependent 10. St. gallen Ki 67 . - 29 . 7 HER2 8 ; HER2 50 0 1 78 12 1 80% HER2 91. 2 6 1 60% . P . HER2 3 . 7 1 70% P . 3 . HER2 0 1 . HER2 2 3 2 .. 8 HER2 Triple . negative ; TN TN 9 ; TN . 76 1% 65% . TN 15 15% 80% . 2 HER2 . TN P .. 9 St. gallen 4 St.

3 gallen . 10 ; 29 1% 15% . 50 2,3 . 1% 80% Ki 67 . - 12 1% 80% . 5 2009 St. gallen . Ki 67 - 20. 11.. St. gallen 2,3 .. Ki 67 . - .. Glycogen rich . - Ki 67 . - Silverberg SG : Atlas of Breast Pathology, Saunders, 2002 .. 12. Ki 67 HER2 . - A ER and/or PgR , HER2 HER2 . B ER and/or PgR , HER2 . HER2 ER PgR HER2 - - HER2 . ER PgR HER2 , cytokeratin 5/6.. - and/or HER1 . St. gallen . 12 Ki 67 . - 3 .. Ki 67 : 1 15% . - - . 16 30% : 30% . - . St. gallen . 3 1 . Ki 67 . - 5 mm . 1% . 11 . Ki 67 - St. gallen .. 6 8 . Ki 67 . - HER2 . 12 . 9 11 .. HER2 . Ki 67 . - . Ki 67 - . 1,2,13 . 4 .. 21. 2 mm studies involving 12,155 patients. Br J Cancer 96 : 1504 1513, 2007. - 6 : : . 14 . 7 : 435 448, 1989. - 7 : .. QOL 21 : 165 169 2006 - 15 8 Elston CW et al : Pathological prognostic factors in breast cancer.

4 I. The value of histological grade in Oncotype DX Mamma breast cancer : Experience from a larger study with Print 16,17 . long term follow up. - - Histopathol 19 : 403 410, - Oncotype 1991. DX Ki 67 - 9 Kurebayashi J et al : The prevalence of intrinsic subtypes and prognosis in breast cancer patients of Ki 67 . - different races. Breast 16 Suppl 2 : S72 77, 2007. - 10 Millikan RC et al : Epidemiology of basal like Ki 67 . - - breast cancer. Breast Cancer Res Treat 109 : 123 - . 139, 2008. 11 Kim MJ et al : Clinicopathologic significance of the basal like subtype of breast cancer : a comparison - Ki 67 . - with hormone receptor and Her2/neu overexpress- - ing phenotypes. Hum Pathol 37 : 1217 1226, - 2006. 12 Neville AM et al : Predicting treatment responsive- ness and prognosis in node negative breast cancer.

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6 gallen International Expert carcinoma. J Surg Oncol 77 : 243 246, 2001. - Consensus on the Primary Therapy of Early Breast 16 Kaklamani VG et al : Gene expression in breast Cancer 2009. Ann Oncol 20 : 1319 1329, 2009. - cancer. Curr Treat Options Oncol 7 : 123 128, - 4 Breast Cancer Treatment Guideline for Patients 2006. Version IV. American Cancer Society/National 17 Knauer M et al : The predictive value of the 70 - Comprehensive Care Network, 2007, 10 gene signature for adjuvant chemotherapy in early 5 E de Azambuja E et al : Ki 67 as prognostic marker - breast cancer. Breast Cancer Res Treat 120 : 655 - in early breast cancer : a meta analysis of published - 661, 2010.