Transcription of 抗菌薬選択に役立つ細菌検査結果 ... - kipn.net
1 1 antibiogram 2 2 4 3 48 Kirby-Bauer E- MIC Minimum Inhibitory Concentration 4 Cooper MIC-MBC : MIC-MBC : ( g/ml) :MICMBC 5 E- MIC S Susceptible I Intermediate R Resistant1.
2 2. CLSI S I R CLSI Clinical and Laboratory StandardsInstitute 6 CLSI S,I,R MIC R MPIPC 4 g/mlMRS CLSI 80 MIC 1 1 8 16 2 2 16 32 1 1 16 32 2 -2 4 1 4 -2 4 PIPC CAZ MEPM AMK LVFX CLSI 7PK/PD Pharmacokinetics (PK)TimeConc. Cmax 1/2 Conc.
3 (log)Effect MIC MBC Postantibiotic effect PAE PK/PD Pharmacodynamics(PD) = 8 Pharmacodynamics(PD)TimePharmacokinetics (PK) (log)EffectPK, PD PK/PD PK/PDEffectTime vs vs vs vs 06121824 Antibiotic concentration g/ml Time hr PK/PD MICAUC24 CmaxPK/PD TAMTime above the MICAUC24/MICCmax/MICAUC24: 9 AGs Cmax/MIC >8-10 VCM:>400>40 1 1 1 1 PAE PAE TAMAUC24/MICPK/PD PAE Cmax/MICAUC24/MICFQs AUC24/MIC GPC>30,GNR>125 CLSI S,I,R
