피부질환치료용 LED 기술동향 및 시장기회 분석

1 LED.. LED - (3 ) - .indd 1 2013-11-26 5:35:34. LED . 2013 10 30 . 2013 1 1 1 . | . | . | . | ( ) 66. | ( ) 245. | 02-3299-6065. | 02-3299-6139. ISBN | 978-89-294-0355-3 93510. , .. , . LED - (3 ) - .indd 2 2013-11-26 5:35:35. LED .. LED 05 . LED 17 . LED 47.. LED 53 . LED 67 . 84 . LED - (3 ) - .indd 3 2013-11-26 5:35:35. LED - (3 ) - .indd 4 2013-11-26 5:35:35. 2 0 1 3.. LED .. LED.. LED - (3 ) - .indd 5 2013-11-26 5:35:35. LED .. (light therapy ) .. , . 1903. Niels Ryberg Finsen , . , , UV (photo- therapy ) . (low level laser therapy : LLLT) . , .. (chromophore) .. (endogenous) . (exogenous) . , 1-1 . 06 @ LED . LED - (3 ) - .indd 6 2013-11-26 5:35:35. 1-1 | . Endogenous Wavelength (nm) Exogenous Wavelength (nm). Nucleic acid 260-280 Psopralens 340-370. Protein 280-300 India ink 400-800. Hemoglobin 400, 542, 554, 576 Indocyanine green 805. Melanin 400-800 Porphyrins 400,630.

2 Water 1400-10000 Chlorins 650-690. Lipid Bacteriochlorins 720-780. Flavins 420-500 Phthalocyanines 670-740. Porphyrins 400,630 Methylene blue 660. Cytochrome 620-900 Rose bengal 540. : RAND(2003. p21) .. , , , , ( . ) .. , .. 405 420 nm : (epidermal) .. (porphyrin) .. 630 640 nm : (dermal) , 80 %. 2 cm .. ATP . (cellular turn- over), (superficial circulation) (anti-inflam- matory emission) . 800 900 nm : . 50 % 8 cm .. LED 07. LED - (3 ) - .indd 7 2013-11-26 5:35:35.. 1-2 , 400. nm 1 mm , 514 nm 1 mm , 630 nm 1 2 mm , 700 . 900 nm 4 mm .. , .. (sebaceous glad) , PDT. (epidermis) (keratoses) .. 1-1 | . : R. Roelandts, 2005. 1-2 | . : Pogue, L. Lilge, Ppatterson et al., 1997. 08 @ LED . LED - (3 ) - .indd 8 2013-11-26 5:35:36.. (Photodynamic therapy : PDT) . (photosensitizer) .. 1-3 . triplet state .. triplet stat .. singlet state , singlet state .. single oxygen .. (apoptosis) (necrosis).

3 , .. T (cutaenous T-cell lymphoma), (vascular tumor), (psoriasis), lichen sclerosis, . (lichen planus), scleroderma, (cutaneous leish- maniasis) .. 1-3 | . : Nature Review Cancer, 2003. LED 09. LED - (3 ) - .indd 9 2013-11-26 5:35:36. LED . LED (FWHM) 30 nm . (non-coherent) .. (non-collimated) . LED , , . , LED .. LED (reducing pain), (inflammation) (edema) .. , .. LED . LED .. LED LED , .. , .. LED .. / .. 010 @ LED . LED - (3 ) - .indd 10 2013-11-26 5:35:36. 1-2 | LED . Application Wavelength(nm) Operation mode Wound healing 660, 850 Pulse Inflammation 630 ~ 660 Pulse PDT 405 ~ 630 Continuous wave Photorejuvenation 630 ~ 660 Pulse Sunburn prevention 660 ~ 970 Pulse or CW. PIH prevention 870 ~ 970 Pulse or CW. Scar prevention 805 ~ 970 CW. Photopreparation 870 ~ 970 CW. Photoregulation 660 ~ 850 Pulse UV-free phtotherapy 405 ~ 850 Pulse or CW.. LED . LED . , (osteoblast), (skeletal muscle cell).

4 (epithelial cell) (cell line) .. , .. , LED , (swelling), . (oozing), (crusting), (pain), (erythema) .. (necrotic) . metalloproteinases .. , (630 1,000nm) . LED , . , .. 670 nm LED cytochrome oxi- dase . , LED . LED 011. LED - (3 ) - .indd 11 2013-11-26 5:35:36. LED LLLT, . , 670. nm LED , .. 670 nm LED 4 J/cm2 . , . LED. , .. LED (physiologic) (patho- logic) . 4 .. LED (in vitro) . , (in vivo) .. 633 nm LED 96 J/cm2 20 . 2 3 .. LED 640 nm 660 nm .. , .. , . 012 @ LED . LED - (3 ) - .indd 12 2013-11-26 5:35:36. 7 1 3 , . 14%, 22% 30% .. 415 nm LED 660 nm LED , 76% .. 630 nm 830 nm . LED . , 635 nm LED .. 635 nm . PGE2 . - LED .. LED .. , .. (rejuvenation).. (rejuvenation) , .. LED .. 400 800 nm LED. 24 27 J/cm2 , .. - (reactive oxygen species) . 20 30 J/cm2 . , .. LED 013. LED - (3 ) - .indd 13 2013-11-26 5:35:36. , (fiberblast) .. LED .. NASA . LED .. LED .. LED (photodynamic therapy : PDT).

5 120 mW/cm2 (40 J/cm2) LED . , 6 .. LED PDT . , (incoherent) LED .. (allergic rhinitis). 660 nm LED . 3 , 14 72. % .. LED 6 J . 660 nm LED .. (anti-inflammatory). 635 nm LED (COX) E2 (cy- clooxygenase prostaglandin E2) .. , 635 nm LED . 014 @ LED . LED - (3 ) - .indd 14 2013-11-26 5:35:36.. 635 nm LED COX . E2 .. 12 144 450 nm LED 8. 50 % .. 34 880 nm LED . J/cm2, 74 mW . 5 .. 880 nm LED .. 660 nm LED 890 nm LED . , . , - . , .. 1-3 1-4 LED . LED . LED 015. LED - (3 ) - .indd 15 2013-11-26 5:35:36. 1-3 | LED .. UV-C LED (250 nm). (100~280 nm) Bio-medicla sensor D . UV-B LED(315 nm). (280~320 nm) , .. UV-A LED(362, 380 nm). (320~400 nm) , .. R, G, B , . LED . (400~780 nm) , . , .. IR-A LED(830 nm). (780nm~ ).. 1-4 | LED .. , .. ( , , ).. , .. , .. ( ).. 016 @ LED . LED - (3 ) - .indd 16 2013-11-26 5:35:36. 2 0 1 3.. LED.. LED.. LED - (3 ) - .indd 17 2013-11-26 5:35:36.. LED.

6 LED . LED . LED, LED (IR LED), . LED(UV LED) , LED , , , LED . LED 90 95 % . LED LED , , , , , .. LED . , . , .. , SMPS .. , .. 018 @ LED . LED - (3 ) - .indd 18 2013-11-26 5:35:36. , , .. LED 2-1 , LED , LED . LED . , . LED LED , LED . LED . LED LED , LED LED .. 2-1 | LED . : (2011). LED . LED (FWHM) 30 nm . (non-coherent) .. (non-collimated) . LED . , , , LED .. LED 019. LED - (3 ) - .indd 19 2013-11-26 5:35:36. LED , . 1 , .. Droop 2 3 .. , 1 3 .. , LED , MOCVD . LED . LED . , . LED . LED .. LED .. LED .. (Nichia Chem- istry), (Toyoda Gosei), (LumiLeds), (Cree), (Osram) , LED.. LED , . , , .. LED . , , . , . , .. , LED .. LED . mm mm .. 2-2 LED . LED . 020 @ LED . LED - (3 ) - .indd 20 2013-11-26 5:35:36.. 400 nm UV 15 mW/chip 850 900 nm 10 mW/chip . 600 700 nm . LED 10 mW/chip , . 650 680 nm LED 5 mW/chip . , LED . LED . 2-2 | LED . : KEIT (2012). 2-3 | LED . : (2011).

7 LED 021. LED - (3 ) - .indd 21 2013-11-26 5:35:36. LED LED . 2-1 . 2-1 | LED . 13~15 16~20 . G aN . G a N .. , , Deep UV LED . , , deep UV LED .. MOCVD (8 . MOCVD (6 ). ).. / c h i p , / chip , .. LED LED . : (2011). LED .. IQE : (IQE) . 60%(B), 20%(G), 80%(R) 90% .. EQE : (EQE) 50% . 80% . : 60% . LED .. LED : . LED MOCVD , capa 2 45 (4 . 11 ) 200% MOCVD , . Cluster Tool . 022 @ LED . LED - (3 ) - .indd 22 2013-11-26 5:35:36. 2-2 | LED .. p , (Al)InGaN , Carrier Overflow , Non/Semi polar , monolithic , InN. , , . (Pillar, Rod, SP, Hybrid, FRET). (Al)GaInP . p AlInP , carrier overflow . Al AlGaN . - deep UV LED AlGaN , AlN , p AlGaN , AlGa(In)N 4 . , , , , , . (Pillar, Rod, SP). LED .. - .. Droop-free . LED . LED LED PCB . LED . LED 2-4 LED. (Die bonding) (Epoxy) . (Solder), (Leadframe) (Body), . (Bonding Wire) . , . PCB .. LED .. , .. LED LED , , , . , , . 20 mA (Normal) 150 mA.

8 (Semipower) , 350 1,000 mA . LED 023. LED - (3 ) - .indd 23 2013-11-26 5:35:36. (High-power) . , , .. 2-4 | LED . 2-5 | LED . : ETRI(2010). LED , . 70 80 % .. , .. LED . (thermal conduction) . , . (Thermal conductivity) , . (Thermal Resistance) . 024 @ LED . LED - (3 ) - .indd 24 2013-11-26 5:35:37.. , LED .. , LED .. 2-6 LED , . 2-7 LED . LED . , . ( ). , LED . ( ), ( . COB ) . 2-6 | LED . : ETRI(2010). 2-7 | LED . : (2011). LED 025. LED - (3 ) - .indd 25 2013-11-26 5:35:37.. LED , .. (lead- frame) .. LED . LED . (Heat Sink) .. 300 /W , 4 . Flux LED 150 /W .. , LED . 10 /W . 2-8 LED .. 2-8 | LED . : (2009).. (Wafer Level Package, WLP) 2-9 . FAB . 026 @ LED . LED - (3 ) - .indd 26 2013-11-26 5:35:37. , .. MEMS . , .. , .. WLP . LED . , .. ( UV ) .. 2-9 | LED . : (2009).. 2-10 . , LED . LED .. UV LED .. LED 027. LED - (3 ) - .indd 27 2013-11-26 5:35:37. , . (Thermal Via).

9 (Heat Slug) . 2-10 | LED . : (2009).. (Metal Package) . 2-11 .. 2 .. 2-11 | LED . : (2009). 028 @ LED . LED - (3 ) - .indd 28 2013-11-26 5:35:37. COB(Chip on Board). LED heat skink .. SMT LED .. LED . , LED . LED array LED array . (junction temperature) , . LED , LED .. LED array . , . 2-12 | COB high power LED . : (2009). LED , . , .. , , . , .. LED .. LED 029. LED - (3 ) - .indd 29 2013-11-26 5:35:37. 2-3 | LED . 13 15 16 20 . LED . LED chip .. 8inch 4inch GaN .. 2 inch GaN .. Metal PCB .. Metal PCB . infiltration .. filler .. : (2011. LED . LED . LED . 2-13 | LED . : ETRI(2010). LED .. LED LED . , . 030 @ LED . LED - (3 ) - .indd 30 2013-11-26 5:35:37.. , LED . 2-14 .. LED .. 2-14 | LED . : ETRI(2010). LED . LED . 2-15. LED . LED . LED. , LED .. 2-15 | LED . : (2009). LED LED .. LED .. , LED . LED 031. LED - (3 ) - .indd 31 2013-11-26 5:35:37.. LED . 2-16 arm hinge LED.)

10 Arm hinge . LED . , . LED .. 2-16 | Arm hinge LED . : (2009). 2-17 LED 4 5 . mock up , .. , .. 2-17 | Mock up LED . : (2009). 032 @ LED . LED - (3 ) - .indd 32 2013-11-26 5:35:37. LED 2-18. LED .. handheld , , , , . LED . LED. , . 2-18 | LED . LED ( ). LED . , , . , .. LED . , , .. LED .. LED . LED . Photo Therapeutics, Ltd ( ). Omnilux LED , 415, 633, 830 3 . 415 blue LED , 633 . PDT , 830 3 . LED 033. LED - (3 ) - .indd 33 2013-11-26 5:35:37.. 415 40 mW/cm2, 633 105 mW/cm2, 830 55 mW/cm2 PDT 633 . 80 mW/cm2 LED .. 2-19 | Photo Therapeutics Ominlux . : Photo Therapeutics Light Bio-Science, LLC( ). GentleWaves LED . 2006 LED FDA .. 590 nm 2000 LED . GentleWaves msec on-off interval . LED . , 90 62 % . , 36 % , 26 % .. L'Oreal .. 034 @ LED . LED - (3 ) - .indd 34 2013-11-26 5:35:37. 2-20 | Light Bio-Science GentleWave LED . : Light Bio-Science Amjo Corp. ( ). LED .. 630 660 LED.