List of API Intermediates CAS No Intermediate Structure

1 List of API IntermediatesDrug NameCAS NoIntermediateStructureAnastrazole2,2-(5 -methyl m-phenylene)bis(2-methylpropionitrile)NN Aripiprazole22246-18-07-Hydroxy-3,4-Di Hydro CarbostyrylNHOOHA lfuzosin-N-(4-Amino-6,7-Dimethoxy-2-Quin azolinyl)-1,3-Propane Di amineHNNH2 NNOONH2 Aripiprazole41202-77-11-(2,3-Dichlorophe nyl) PiperazineNHNClClBicalutomide2-trifluoro methyl-4-aminobenzonitrileNH2 NFFFC innarazine841-77-0N-Benzhydryl PiperazineNNHList of API IntermediatesDrug NameCAS NoIntermediateStructureCinnarazine5321-6 3-1N-Benzyl Piperazine 2 PiperazineNHNOOC innarazine78818-15-24-Benzyl-2-OXO-Piper azineNHNOC innarazine76003-29-74-BOC-2-OXO-Piperazi neHNNOOOC innarazine41202-32-81-(2-Chlorophenyl) Piperazine HClNHNClHClCetirizine303-26-41-(4-Chloro benzhydryl) PiperazineNNHClList of API IntermediatesDrug NameCAS NoIntermediateStructureDapiprazole39512- 51-11-(o-Tolyl) PiperazineNHNE rlotinib6,7-dihydroxy quinazolineNNHOHOE rlotinib2-methoxy ethyl bromideOBrErlotinib3-amino styreneH2 NFluanisone5464-78-81-(2-Methoxyphenyl) PiperazineNNHOF luanisone6968-76-91-(3-Methoxyphenyl) Piperazine of API IntermediatesDrug NameCAS NoIntermediateStructureGefitinib6-hydrox y-7-methoxy quinazolineNNOOHG abapentin99189-60-31,1 Cyclohexane Diacetic Acid MonoamideONH2 ONH2 Gabapentin64744-50-92-Azaspiro [ ] Decan-3-one (Gabalactam)HNOI matinib4-((4-methyl-1-piperazinyl)methyl )benzoylchloride dihydrochlorideOClNNHClHClImatinib106261 -49-84-(4-Methyl Piperazino methyl) Benzoic Acid2 HClOOHNNHClHClItraconazole46415-29-61-(4 -Methoxyphenyl) PiperazineNNHOList of API IntermediatesDrug NameCAS NoIntermediateStructureItraconazole74852 -61-21-(4-Methoxyphenyl)-4-(4-Nitropheny l)PiperazineNNN+O-OOItraconazole74852-62 -31-(4-Methoxyphenyl)-4-(4-Aminophenyl)P iperazineNNH2 NOItraconazole6269-89-21-(4-Nitrophenyl)

2 PiperazineNNHN+O-OItraconazole5625-67-22 -OXO-PiperazineHNNHOI traconazole57260-70-51-Boc-4-Benzyl PiperazineNNOOK etoconazole67914-60-7N-Acetyl-4-(4-Hydro xyphenyl) PiperazineNNHOOList of API IntermediatesDrug NameCAS NoIntermediateStructureKetorolac[598-10- 7]Cyclopropane-1,1-dicarboxylic AcidCOOHCOOHK etorolac[1559-02-0]Diethyl Cyclopropane-1,1-dicarboxylateCOOC2H5 COOC2H5 Ketorolac[17201-43-3]6,6-Dimethyl-5,7-di oxa-spiro(2,5)octane-4,8-dioneOOOOK etorolac1-[3,3-Dimethoxy carbonyl propyl]-2,3-dibromo-5-benzoyl pyrroleCNBrOBrHCCCOOCH3 OOCH3 Ketorolac[13182-89-3]5-Benzoyl-2,3-dibro mo pyrroleNHOBrBrList of API IntermediatesDrug NameCAS NoIntermediateStructure[1759-53-1]Cyclop ropane-1-carboxylic acidCOOHL etrazole4-(1,2,4-triazole-yl-methyl)benz onitrileNNNNL evocetirizine130018-88-11-[(S)-(4-chloro phenyl)(phenyl)methyl]piperazineNHNClNeb ivolol99199-60-76-Fluoro-3,4-Dihydro-2H- 1-Benzopyran-2-Carboxylic AcidOOHOFN ebivolol394-32-15'-Fluoro-2'-hydroxyacet ophenoneOHOFN ebivolol2-Chloro-N-Cyclo Propyl AcetamideOHNClList of API IntermediatesDrug NameCAS NoIntermediateStructureNiaprazine64090-1 9-31-(4-Fluorophenyl) PiperazineNNHFN iaprazine7755-92-2N-Formyl PiperazineNNHON iaprazine56621-48-8N-(4-Hydroxyphenyl) PiperazineNNHHOO xiracetam1668-10-6 Glycinamide HydrochlorideH2 NONH2 HClOxiracetam97-97-2 Chloroacetaldehyde Dimethyl AcetalClOOOxiracetamCyanoacetaldehyde Dimethyl acetalNOOList of API IntermediatesDrug NameCAS NoIntermediateStructureOxiracetam7252-83 -7 BromoacetaldehydeDimethyl acetalBrOOQuetiapine13349-82-11-[2-(2-Hy droxyethoxy) Ethyl] PiperazineNHNOOHQ uetiapine120-43-4N-Carbethoxy piperazineNHNOOR izatriptan benzoate1-(4-aminobenzyl)-1,2,4-triazole NNNH2 NRopinirole120427-95-44-(2 -Bromoethyl)

3 -3-Chloro-1,3-Dihydro-2H-Indole-2-OneNHO ClBrRamipril[93779-31-8][1S,3S,5S]-2-Aza bicyclo( )-octane-3-carboxylic acid benzyl ester HClNHOOHHHClList of API IntermediatesDrug NameCAS NoIntermediateStructureAlfuzosinPrazosin [23680-84-4]4-Amino-2-chloro-6,7-dimetho xy quinazolineNNH3 COH3 COClNH2 Sunitinib5-fluoro-2-oxo-indoleNOFD oxazosinTerazosin[28888-44-0]6,7-Dimetho xy-2,4-quinazoline dioneNHHNH3 COH3 COOOT elmisartan25148-68-9N-Methyl-1, 2-benzenediaminedihydrochlorideHNH2 NHClHClTelmisartan152628-03-04-Methyl-2- n-propyl-1H-benzimidazole-6-carboxylic acidNNHOHOT elmisartan152628-02-92-n-Propyl-4-methyl -6-(1-methylbenzimidazole-2-yl) benzimidazoleNNHNNList of API IntermediatesDrug NameCAS NoIntermediateStructureTelmisartan876-08 -4(4-chloromethyl) Benzoyl ChlorideOClClTelmisartan[25148-68-9]N-Me thyl-O-Phenylenediamine 2 HClNH2 NHCH32 HClTelmisartan[114772-38-2]4 -Bromomethyl biphenyl-2-carboxylic acidmethyl esterCOOCH3 BrTelmisartan[7148-03-0]4 -Methyl biphenyl carboxylic acidCOOHT elmisartan[114772-34-8]4 -Methyl biphenyl carboxylic acid methyl esterCOOCH3 Topiramate[20880-92-6]2,3:4,5-di-O-isopr opylidene- -D-fructopyranoseOCH2 OHOOOOList of API IntermediatesDrug NameCAS NoIntermediateStructureTrazodone65369-76 -81-(3-Chlorophenyl) PiperazineNHNClTrazodone38869-46-41-(4-C hlorophenyl) Piperazine 2 HClNNHClHClHClTerconazole67914-97-0N-Iso propyl-4-(4-hydroxyphenyl)-piperazineNNH OT opiramate120427-95-42,3:4,5-Bis-O-(1-Met hylethylidene)- -D-FructopyranoseHOOOOOO