Example: tourism industry

Logopenic aphasia or Alzheimer’s disease

Dement Neuropsychol 2014 September;8(3):302-307 Case Report Logopenic aphasia or alzheimer 's disease Different phases of the same disease ? B rbara Costa Beber1,2,3, Renata Kochhann1,4,5, Bruna Matias da Silva1, Marcia L. F. Chaves1,2,6. ABSTRACT. The Logopenic variant of Primary Progressive aphasia , or Logopenic aphasia , is a the most recently described variant of Primary Progressive aphasia and also the least well defined. This variant can present clinical findings that are also common to alzheimer 's disease , given they both share the same cytopathologic findings. This article reports the clinical case of a patient for whom it proved difficult to define a clinical diagnosis, being split between the Logopenic variant and alzheimer 's disease at different phases of the disease .

Dement europsychol 2014 eptember3):302-307 Beber BC et al. Logopenic aphasia or Alzheimer’s disease 303 housewife. The patient was referred to the Dementia

Tags:

  Disease, Alzheimer, Dementia, Aphasia, Logopenic aphasia or alzheimer s disease, Logopenic

Information

Domain:

Source:

Link to this page:

Please notify us if you found a problem with this document:

Other abuse

Transcription of Logopenic aphasia or Alzheimer’s disease

1 Dement Neuropsychol 2014 September;8(3):302-307 Case Report Logopenic aphasia or alzheimer 's disease Different phases of the same disease ? B rbara Costa Beber1,2,3, Renata Kochhann1,4,5, Bruna Matias da Silva1, Marcia L. F. Chaves1,2,6. ABSTRACT. The Logopenic variant of Primary Progressive aphasia , or Logopenic aphasia , is a the most recently described variant of Primary Progressive aphasia and also the least well defined. This variant can present clinical findings that are also common to alzheimer 's disease , given they both share the same cytopathologic findings. This article reports the clinical case of a patient for whom it proved difficult to define a clinical diagnosis, being split between the Logopenic variant and alzheimer 's disease at different phases of the disease .

2 Using this case as an example and drawing on the latest evidence from the literature on the Logopenic variant, we postulate the hypothesis that this variant may present as an initial symptom of alzheimer 's disease in some atypical cases. Key words: Logopenic aphasia , alzheimer 's disease , Primary Progressive aphasia , diagnosis. AFASIA LOGOP NICA OU DOEN A DE alzheimer : DIFERENTES FASES DA MESMA DOEN A? RESUMO. A variante logop nica da Afasia Progressiva Prim ria, ou afasia logop nica, a variante mais recentemente descrita entre todas as variantes da Afasia Progressiva Prim ria e, tamb m por isso, a menos definida.

3 Essa variante pode apresentar achados cl nicos em comum com a doen a de alzheimer pelo fato de compartilharem o mesmo achado citopatol gico. Este artigo descreve o caso cl nico de uma paciente na qual se evidenciou uma dificuldade em assumir o diagn stico cl nico que se dividia entre a variante logop nica e a doen a de alzheimer em determinadas fases da doen a. Utilizando este caso como exemplo e as atuais evid ncias que a literatura apresenta sobre a variante logop nica, levantamos a hip tese de que essa variante pode apresentar-se como uma manifesta o inicial da doen a de alzheimer em alguns casos menos t picos.

4 Palavras-chave: afasia logop nica, doen a de alzheimer , Afasia Progressiva Prim ria, diagn stico. INTRODUCTION or parietal atrophy and typical association P rimary Progressive aphasia (PPA) is a term used to describe a group of neurode- generative diseases that predominantly affect with the pathological finding of alzheimer 's disease (AD). Given that this variant has only recently been defined, descriptions of lvPPA. ,2 The term encompasses three dif- and atypical cases remain relatively scarce, ferent variants, each with a specific language with fewer case studies and descriptions avail- profile: semantic, agrammatic/non-fluent able compared to the other variants.

5 Thus, and Logopenic . The diagnosis of PPAs has the objective of this article is to report a clini- long been restricted to the non-fluent and se- cal case for which it proved difficult to define mantic variants, where Logopenic aphasia has a clinical diagnosis, being split between lvPPA. only recently been defined, based on the di- and AD at different phases of the disease . agnostic criteria of Gorno-Tempini et The Logopenic variant of PPA (lvPPA) is character- CASE DESCRIPTION. ized by difficulties in single-word retrieval, We report the case of JCF, a 74-year-old fe- repetition of sentences/phrases, presence of male patient with 3 years of schooling, a phonologic errors, left posterior perisylvian native speaker of Brazilian Portuguese and 1.

6 MSc, dementia Clinic, Neurology Service, Hospital de Cl nicas de Porto Alegre (HCPA), RS, Brazil. 2 PhD, Post-graduate Program in Medicine: Medical Sciences, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre (UFRGS), RS, Brazil. 3 CAPES Doctoral scholarship. 4 Post-graduate Program in Psychology of the School of Psychology of the Pontif cia Universidade Cat lica do Rio Grande do Sul (PUCRS), RS, Brazil. 5 CAPES Post-doctoral scholarship. 6 Department of Internal Medicine, School of Medicine, UFRGS, RS, Brazil. M rcia L. F. Chaves. Rua Ramiro Barcelos, 2350 / sala 2040 90035-903 Porto Alegre Brazil.

7 E-mail: Disclosure: The authors report no conflicts of interest. Received March 20, 2014. Accepted in final form June 29, 2014. 302 Logopenic aphasia or alzheimer 's disease Beber BC, et al. Dement Neuropsychol 2014 September;8(3):302-307. housewife. The patient was referred to the dementia Test (BNT);7 Digit Span Subtest (backward and forward). Clinic of a University Teaching Hospital located in the from the WAIS III;9 Clock Drawing Test (CDT);10 Mon- south of Brazil in October, 2012. During the first visit, treal-Toulouse Language Assessment Battery (MTL),11. the patient was accompanied by her husband who pro- Phonemic Verbal Fluency (FAS)12 and Semantic Verbal vided all information owing to the her communication Fluency (animals).

8 13 The patient was unable to perform difficulties. The husband reported the main complaint some of the tests owing to the difficulties exhibited as being a memory impairment which began in 2010. (GDS and subtests Words list recall and Words list . According to him, onset was abrupt and manifested recognition from the CERAD). with the forgetting names of people and objects, home The results of the tests applied are shown in Table 1, address as well as her way of cooking. After a more in- together with the expected scores based on normative depth review of the initial symptoms, the husband re- reference values for the Brazilian population.

9 Ported that the problems were predominantly saying In addition, an informal assessment of spontaneous the names of everyday objects properly and remember- speech was performed during the medical and cognitive ing how to write words, for instance, the patient would assessment. No motor deficits or impairments in plan- refer to a glass or pen as thing because she was un- ning of speech motor acts, such as dysarthria or verbal able to recall the name of objects. However, the report apraxia were found. The patient also reported no swal- was not consistent with impaired memory per se, par- lowing complaints. Pauses during speech, word-finding ticularly for the episodic type.

10 Additionally, the husband difficulties and utterance of short sentences, as well as reported a steady decline since onset of the forgetful an absence of agrammatism were also observed. Com- condition, evidencing the progressive nature of symp- prehension difficulties were observed in situations in- toms. Yet despite this decline, he reported the patient volving complex speech but not when simple sentences continued to perform domestic chores, except for cook- and single words were used. ing, demonstrating some degree of independence in ac- Laboratory exams and neuroimaging exams were or- tivities of daily living.


Related search queries