MAURIZIO BALESTRINO, MD CURRICULUM VITAE …

1 MAURIZIO balestrino , MD CURRICULUM VITAE Born in Genova, Italy, Feb. 9, 1956. Citizenship: Italian 1980: Degree in Medicine and Surgery, with honors 1984: Specialist in Neurology Diploma. Languages spoken: Italian (mother language), English (good), French (medium) POSITIONS 1980-1983: Resident in Neurology, University of Genova. 1983-1986: Research Associate, Dept Physiology, Duke Univ. Medical Center 1987 -1993: National Research Council (Genova, Italy), external collaborator. Consultant Neurologist, Italian Army, Genova. Italian Publich Health System, several outpatients facilities -Neurologist Specialist Visiting scientist at Duke University, Univ.

2 Of Washington, Univ. of Ottawa. 1993-present: Senior Researcher, Department of Neuroscience, Ophthalmology and Genetics, University of Genova. Chief of the Laboratory of Experimental Neurophysiology. MAJOR FUNDING 1998-2000: Assoc. Partner, In vitro neurotoxicology tests based on the coupling of brain slices to silicon microelectrode arrays (European Commission) 2001-2004: Coordinator, Development of new creatine-derived drugs with potent capability of increasing cerebral high-energy stores (INTAS) 2004-2007: Coordinator, Creatine administration to creatine deficiency syndromes (Telethon) 2011-2013: Partner An investigation on genetics, endothelial function and advanced neuroimaging of sporadic and familial (CADASIL and CADASIL-like) cases of cerebral microangiopathy (Italian Ministry of University) INVITED SPEAKER, INTERNATIONAL MEETINGS "Mechanisms of Cerebral Hypoxia and Stroke" (Budapest, 1987) "Central Nervous System Slice Preparation" (Louisville, 1994) IVTIP (In Vitro Testing Industrial Platform) Annual Meeting (Amboise, 2004) PEER REVIEW AND EVALUATIONS 2007: Remote and on-site expert proposal evaluator for the FP7 project of the European Commission ("Health" area).

3 1990-present: peer-reviewer for several scientific journals, including Brain Research, Neuroscience, Neuroscience Letters, International Journal of Neuroscience, Molecular Genetics and Metabolism, Neurobiology of Disease, Neurological Sciences, Pharmacology Biochemistry and Behaviour, PlosOne. 1995-present: grant proposal evaluator for several Agencies, including alzheimer s association , Italian ministry of University and Research, INTAS (International association for the promotion of co-operation with scientists from the New Independent States of the former Soviet Union), Serbian Government. 2012-present: ad-hoc consultant to Italian Ministry of University to monitor the multicentric project "Cyber Brain" using EU funds for underdeveloped areas; proposal evaluator for INTAS and for Italian and Serbian Governments.

4 SCIENTIFIC PUBLICATIONS ARTICLES IN JOURNALS P. Sandercock, R. Lindley, J. Wardlaw, M. Dennis, K. Innes, G. Cohen, W. Whiteley, D. Perry, V. Soosay, D. Buchanan, G. Venables, A. Czlonkowska, A. Kobayashi, E. Berge, K. B. Slot, V. Murray, A. Peeters, G. J. Hankey, K. Matz, M. Brainin, S. Ricci, T. A. Cantisani, G. Gubitz, S. J. Phillips, A. Antonio, M. Correia, P. Lyrer, I. Kane, E. Lundstrom, and the IST-3 collaborative group. Update on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited. Trials 12:252, 2011. P. Sandercock, J. M. Wardlaw, R.

5 I. Lindley, M. Dennis, G. Cohen, G. Murray, K. Innes, G. Venables, A. Czlonkowska, A. Kobayashi, S. Ricci, V. Murray, E. Berge, K. B. Slot, G. J. Hankey, M. Correia, A. Peeters, K. Matz, P. Lyrer, G. Gubitz, S. J. Phillips, A. Arauz, and the IST-3 collaborative group. The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial. Lancet 379 (9834):2352-2363, 2012. S. Ravera, E. Adriano, M. balestrino , and I. Panfoli. Creatine ethyl ester: a new substrate for creatine kinase. Mol Biol.

6 (Mosk) 46 (1):162-165, 2012. MAURIZIO balestrino , Paola Fontana, Serena Terzuoli, Silvia Volpe, Maria Laura Inglese, and Leonardo Cocito. Altered Handwriting Suggests Cognitive Impairment and May Be Relevant to Posthumous Evaluation. Journal of Forensic Sciences:no, 2012. L. Perasso, P. Spallarossa, C. Gandolfo, P. Ruggeri, and M. balestrino . Therapeutic use of creatine in brain or heart ischemia: available data and future perspectives. Med Res Rev, 2011. E. Adriano, P. Garbati, Damonte G., Salis A., and balestrino M. Searching for a therapy of creatine transporter deficiency: some effects of creatine ethyl ester in brain slices in vitro.

7 Neuroscience 199:386-393, 2011. Enrico Adriano, Luisa Perasso, Isabella Panfoli, Silvia Ravera, Carlo Gandolfo, Gianluigi Mancardi, Alessandro Morelli, and MAURIZIO balestrino . A Novel Hypothesis About Mechanisms Affecting Conduction Velocity of Central Myelinated Fibers. Neurochemical Research 36 (10):1732-1739, 2011. Perasso L., Cogo CE, Giunti D, Gandolfo C, P. Ruggeri, Uccelli A, and balestrino M. Systemic Administration of Mesenchymal Stem Cells Increases Neuron Survival after Global Cerebral Ischemia In Vivo (2VO). Neural Plasticity 2010 (Article ID 534925, 5 pages): , 2010. Francesca Pescini, Francesca Cesari, Betti Giusti, Cristina Sarti, Enza Zicari, Silvia Bianchi, Maria T.

8 Dotti, Antonio Federico, MAURIZIO balestrino , Adriano Enrico, Carlo Gandolfo, Anna M. Gori, Rosanna Abbate, Leonardo Pantoni, and Domenico Inzitari. Bone Marrow-Derived Progenitor Cells in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy. Stroke 41 (2):218-223, 2010. L. Perasso, E. Adriano, P. Ruggeri, S. V. Burov, C. Gandolfo, and M. balestrino . In vivo neuroprotection by a creatine-derived compound: Phosphocreatine-Mg-complex acetate. Brain Research 1285:158-163, 2009. Luisa Perasso, Gian Lunardi, Federica Risso, Anna Pohvozcheva, Maria Leko, Carlo Gandolfo, Tullio Florio, Aroldo Cupello, Sergey Burov, and MAURIZIO balestrino .

9 Protective Effects of Some Creatine Derivatives in Brain Tissue Anoxia. Neurochemical Research 33 (5):765-775, 2008. balestrino M, Gandolfo C, and Perasso L. Controlling the flow of energy: inhibition and stimulation of the creatine transporter. Current enzyme inhibition 5 (4):223-233, 2009. C. Gandolfo, M. balestrino , A. Burrone, Sette M. Del, and C. Finocchi. Stroke due to atrial fibrillation and the attitude to prescribing anticoagulant prevention in Italy. A prospective study of a consecutive stroke population admitted to a comprehensive stroke unit. J Neurol 255 (6):796-802, 2008. L pez-Viota Juli n, Subhra Mandal, Angel V.

10 Delgado, Jos Luis Toca-Herrera, M ller Marco, Francesco Zanuttin, MAURIZIO balestrino , and Silke Krol. Electrophoretic characterization of gold nanoparticles functionalized with human serum albumin (HSA) and creatine. Journal of Colloid and Interface Science 332 (1):215-223, 2009. Paola Fontana, Francesca Dagnino, Leonardo Cocito, and MAURIZIO balestrino . Handwriting as a gauge of cognitive status: a novel forensic tool for posthumous evaluation of testamentary capacity. Neurological Sciences 29 (4):257-261, 2008. Gandolfo C, balestrino M, Del Sette M, Dinia L, and De Salvo L. Percutaneous endoscopic gastrostomy in dysphagia due to cerebrovascular disease.