MEDICINES CONTROL COUNCIL - mccza.com

1 Licensing Licence to Manufacture, Import or Export, Act as a Wholesaler or Distributor Oct 2017 Page 1 of 27 MEDICINES CONTROL COUNCIL LICENCES ISSUED IN TERMS OF SECTION 22C of the MEDICINES and RELATED SUBSTANCES ACT, 1965 MANUFACTURERS, IMPORTERS, EXPORTERS WHOLESALER, DISTRIBUTOR Licences to manufacture, import or export, or act as a wholesaler to wholesale and or distribute MEDICINES are issued in accordance with the requirements of Section 22C read with Regulation 19 of the MEDICINES and Related Substances Act, 1965 (Act 101 of 1965) Licences issued until September 2017 DR JC GOUWS REGISTRAR OF MEDICINES Licensing Licence to Manufacture, Import or Export, Act as a Wholesaler or Distributor Oct 2017 Page 2 of 27 COMPANY NAME LICENCE NO RESIDENTIAL ADDRESS POSTAL ADDRESS TYPE OF LICENCE AND AUTHORISED SITE ACTIVITY MANUFACTURER, IMPORTER, EXPORTER, LABORATORY 1 Acorn Pharmaceuticals (Pty) Ltd 0000000587 Unit 13/14 Cnr Minis, Northlands Business Park, New Market Rd, North Riding, 2162 P O Box 1096, Durbanville, 7551 Manufacture 2 Adcock Ingram Critical Care (Pty)

2 Ltd 0000000665 1 Sabax Road, Aeroton, Johannesburg, 2013 P O Box 6888, Johannesburg, 2000 Manufacture, Import & Export 3 Adcock Ingram Healthcare (Pty) Ltd Clayville 0000000613 Cnr Axle Drive and Baksteen Road, Clayville, Olifantsfontein, Johannesburg, 1665 P O Box 489, Olifantsfontein, Johannesburg, 2021 Manufacture, Import & Export 4 Adcock Ingram Healthcare (Pty) Ltd Wadeville 0000000615 1 Murray Road, Wadeville, Germiston, 1428 Private Bag X69, Bryanston, Johannesburg, 2021 Manufacture, Import & Export 5 Adcock Ingram Limited Research & Development 0000000807 1 Sabax Road, Aeroton, Johannesburg, 2013 Private Bag X69, Bryanston, Johannesburg, 2021 Manufacture 6 African Oxygen Ltd Bloemfontein Filling 0000000383 Maasdorp, Old Industrial Site, Bloemfontein, 9301 P O Box 5404, Johannesburg, 2000 Manufacture & Export 7 African Oxygen Ltd East London 0000000370 Cnr Settlers Way and Dunlop Rd, Gateley Township.

3 East London, 5201 P O Box 5404, Johannesburg, 2000 Manufacture & Export 8 African Oxygen Ltd Gases Operation Centre (Germiston) 0000000467 Gate 2, Barlow Street, Industries West, Germiston, Gauteng, 1401 P O Box 5404, Johannesburg, 2000 Manufacture & Export 9 African Oxygen Ltd George 0000000367 Albert Street, Industrial Area, Cape Town, 6529 P O Box 1570, Bedfordview, Johannesburg, 2008 Manufacture & Export 10 African Oxygen Ltd Highveld Process Operations Plant 0000000381 Old Pretoria Road, Witbank, 1035 P O Box 5404, Johannesburg, 2000 Manufacture & Export 11 African Oxygen Ltd Kimberley 0000000371 7 Stadium Road, Kimberley Industrial, Kimberley, 8301 P O 1570, Bedfordview.

4 2008 Manufacture & Export 12 African Oxygen Ltd Kuilsriver Process Operation Plant 0000000378 42 Fabriek Street, Kuils River, 7580 P O Box 5404, Johannesburg, 2002 Manufacture & Export 13 African Oxygen Ltd , Durban Filling 0000000384 Corobrick Road, Riverhorse Valley B Es, Durban, 3630 P O Box 5404, Johannesburg, 2000 Manufacture & Export 14 African Oxygen Ltd Mosselbay 0000000359 Petro SA Petrochemical Plant, Mosselbay, 6500 P O Box 5404, Johannesburg, 2000 Manufacture & Export 15 African Oxygen Ltd NCP CO2 Process Operations Plant Umgeni 0000000875 Sea Cow Lake Road, Umgeni, Durban P O Box 5404, Johannesburg, 2000 Manufacture & Export 16 African Oxygen Ltd Nelspruit 0000000360 10 Wolfaardt Street, Nelspruit Ext 2, Nelspruit, 1200 P O Box 1570, Bedfordview, Johannesburg, 2008 Manufacture 17 African Oxygen Ltd Newcastle 0000000368 5 Edison Street, Riverside, Newcastle, 2940 P O Box 1570, Bedfordview.

5 2008 Manufacture & Export 18 African Oxygen Ltd Pietermaritzburg Process Operation Plant 0000000355 Moses Mabhida Road, Pietermaritzburg, 3201 P O Box 5404, Johannesburg, 2000 Manufacture & Export Licensing Licence to Manufacture, Import or Export, Act as a Wholesaler or Distributor Oct 2017 Page 3 of 27 COMPANY NAME LICENCE NO RESIDENTIAL ADDRESS POSTAL ADDRESS TYPE OF LICENCE AND AUTHORISED SITE ACTIVITY MANUFACTURER, IMPORTER, EXPORTER, LABORATORY 19 African Oxygen Ltd Port Elizabeth 0000000373 135 Burman Road, Deal Party, Port Elizabeth, 6001 P O Box 5404, Johannesburg,2000 Manufacture & Export 20 African Oxygen Ltd Pretoria West Process Operation Plant 0000000852 20 Roger Dyason Road, Pretoria West, Pretoria, 0117 P O Box 5404, Johannesburg, 2000 Manufacture & Export 21 Afrika Biopharma Manufacturing (Pty) Ltd 0000000204 19 Potgieter Street, Alrode, Johannesburg, 1449 P O Box 123784, Alrode, 1449 Manufacturer & Testing 22 Air Liquide (Pty)

6 Cape Town 0000000868 37 Bofor Circle, Epping Industrial Township, Maitland, Goodwood, Cape Town, 7460 P O Box 124200, Alrode, 1451 Manufacture 23 Air Liquide (Pty) Ltd Alrode 0000000345 Cnr Vereeniging & Andre Marais Street, Alrode, Gauteng, 1451 P O Box 124200, Alrode, 1451 Manufacture & Export 24 Air Products (Pty) Ltd Kempton Park 0000000855 Cnr Plane & Prevett Roads, Spartan Ext 1, Kempton Park, Johannesburg, 1620 Private Bag X02, Kempton Park, Johannesburg, 1620 Manufacture 25 Air Products (Pty) Ltd Vanderbijlpark 0000000854 Cnr McColm & Delfos Boulevards, Vanderbijlpark, Gauteng, 1900 Private Bag X02, Kempton Park, Johannesburg, 1620 Manufacture 26 Akacia HealthCare (Pty) Limited 0000000983 4 Brewery Street, Isando, Johannesburg, 1601 P O Box 194, Isando, JHB, 1600 Manufacture, Import & Export 27 Altis Biologics (Pty) Ltd 0000000812 The Innovation Hub, 6 Mark Shuttleworth, Biopark Building, Lynnwood, Pretoria, 0087 The Innovation Hub, 6 Mark Shuttleworth, Biopark Building, Lynnwood, Pretoria, 0087 Manufacture 28 Ascendis Supply Chain (Pty)

7 Ltd 0000000603 1 Carey Street, Wynberg, Gauteng, 2012 P O Box 494, Bergvlei, Gauteng, 2012 Manufacture, Import & Export 29 Aspen Port Elizabeth (Pty) Ltd 0000001018 Cnr Fairclough Road & Gibaud Road, Korsten, Port Elizabeth, 6014 Box 4002, Port Elizabeth, 6014 Manufacture, Import & Export 30 Aspen pharmacare East London (Pty) Ltd 0000000549 Robbie De Lange Road, Wilsonia, East London, 5201 P O Box 422, East London, 5200 Manufacture 31 Aspen SVP 0000001068 8b Gibaud Road, Korsten, Port Elizabeth, 6014 P O Box 4002, Korsten, Port Elizabeth, 6014 Manufacture, Packer & Testing 32 Azochem Laboratories (Pty)

8 Ltd 0000000219 250 Nadine Strteet, Robertville, Roodepoort, 1709 P O Box 375, Maraisburg, 1700 Manufacturer & Testing Laboratory 33 Medical Pharmaceuticals 0000000679 25 Tsessebe Crescent, Corporate Park, Midrand, 1685 P O Box 1787, Randburg, 2125 Manufacturer, Import & Export 34 Barrs Pharmaceuticals Industries (Pty) Ltd 0000000215 10 Inyoni Street, Ndabeni, Cape Town, 7405 P O Box 7348, Roggebaai, 8012 Manufacture, Import & Export 35 California Pharmaceuticals (Pty) Ltd t/a Calpharm 0000000685 17 Edison Crescent, Hennopspark, Centurion, 0157 P O Box 8392, Centurion, 0046 Manufacture, Import & Export 36 Cipla Medpro (Pty) Ltd t/a Cipla Medpro Manufacturing 0000000729 1474 South Coast Road, Mobeni, Durban, 4060 P O Box 32003, Mobeni, Durban, 4060 Manufacture & Testing 37 Columbia Pharmaceuticals (Pty)

9 Ltd 0000000179 Plot 73, Middle Road, Bardene Ext 32, Boksburg, Johannesburg, 1459 P O Box 7026, Bonaero Park, 1622 Manufacture, Packer & Testing 38 Divpharm Manufacturing & Packaging Agvet Site 0000000264 19 Maraisburg Road, Industria, Johannesburg, 2093 P O Box 490, Cramerview, 2060 Manufacture Licensing Licence to Manufacture, Import or Export, Act as a Wholesaler or Distributor Oct 2017 Page 4 of 27 COMPANY NAME LICENCE NO RESIDENTIAL ADDRESS POSTAL ADDRESS TYPE OF LICENCE AND AUTHORISED SITE ACTIVITY MANUFACTURER, IMPORTER, EXPORTER, LABORATORY 39 Divpharm Manufacturing & Packaging Longdale 0000000669 25 Longdale Loop, Longdale, Industria, 2093 P O Box 490, Cramerview, 2060 Manufacture & Export 40 DRA Pharmaceuticals CC 0000000961 15 Victoria Link, Route 21 Corporate Park, Irene X31, Pretoria P O Box 100866, Moreleta, 0044 Manufacture 41 Fresenius Kabi Manufacturing SA (Pty) Ltd Korsten, PE 0000000181 6 Gibaud Road, Korsten, Port Elizabeth, 6020 P O Box 4394, Korsten, Port Elizabeth, 6014 Manufacture, Import & Export 42 Fresenius Kabi South Africa (Pty)

10 Limited 0000000185 Stand 7, Growth Point, 2 Tonetti Street, Halfway House, Midrand, Johannesburg, 1685 P O Box 4156, Halfway House, Midrand, 1685 Manufacture, Import & Export 43 Genzyme Pharmaceuticals South Africa (Pty) Ltd 0000001017 Bryanston Corner, Building B, 18 Ealing Crescent, Bryanston, Gauteng, 2191 P O Box 67013, Bryanston, Gauteng, 2021 Manuf