Ministero della Salute

1 Ministero della SaluteDirezione Generale della Ricerca e dell' Innovazione in Sanit BANDO RICERCA FINALIZZATA 2016 GRADUATORIA SEZIONE ORDINARIA RFCriteri Sub RankingRANKC odiceProgettoTipo RicercaTitolo ProgettoDISCORE FINALER ispondenza RilenvanzaQualit ScientificaChiarezza e AppropiatezzaTrasferibilit nel SSNCVS core Impatto ) Theory enhancing:Targeting the tumor vasculature with TNF bearing nanoparticles tagged with a non deamidating NGR peptideSAN RAFFAELE MILANO15,5011,51,51,531RF 2016 023610546,008,502a) Theory enhancing:The FEDRA (Florence EPIC Digital mammographic density and breast cancer Risk Assessment) Study: Determinants of mammographic breast density and breast cancer risk in a large cohort of women with repeated breast density measurements based on full field digToscana15,50132,51,521RF 2016 023647458,506,003a) Theory enhancing:Does exercise training mostly unmask congenital long QT syndrome or simply reveals a novel form of acquired long QT syndrome in genetically predisposed youngsters practicing sports?

2 Ethical and medical implications of a potentially dangerous ,50222,521,51RF 2016 023615018,006,504a) Theory enhancing:Biological basis for Zika virus induced severe complications: impact on prevention strategiesSPALLANZANI15,751222,521RF 2016 023641558,506,255c) Change promoting:Italian Rare Cancer Network: Process monitoring and System impact TUMORI MILANO16,0011,7522,2513RF 2016 023633867,505,50 Pagina 1 di 94 Bando Ricerca Finalizzata 2016 Graduatoria Sezione Ordinaria RFCriteri Sub RankingRANKC odiceProgettoTipo RicercaTitolo ProgettoDISCORE FINALER ispondenza RilenvanzaQualit ScientificaChiarezza e AppropiatezzaTrasferibilit nel SSNCVS core Impatto ) Change promoting:Efficacy and tolerability of low vs. standard daily doses of antiepileptic drugs in newly diagnosed, previously untreated epilepsy. A multicenter, randomized, single blind, parallel group trialMARIO NEGRI16,0022,51113RF 2016 023639027,505,507a) Theory enhancing:Characterization of the RBX1 E3 ligase as a negative regulator of the tumor suppressor Numb and target for anti cancer stem cell therapies in Numb deficient breast ,2512,52,522,751RF 2016 023615409,007,258a) Theory enhancing:Intestinal microbiome biomarkers for non celiac gluten sensitivity: new diagnostic and therapeutic Romagna17,2521,51,51,52,751RF 2016 023648145,5010,759b) Change promoting:Efficacy of Albumin Replacement and Balanced Crystalloid Solutions in Septic Shock (the ALBIOSS BALANCED trial): a 2 by 2 factorial, investigator initiated, open label, multicenter, randomized, controlled ,00222,52,521RF 2016 023615839,008,0010b) Change promoting:The Pediatric Autoimmunity and Diabetes (PAD) Project: towards an optimal use of public resources in Diabetes CareSAN RAFFAELE MILANO18,25132,531,252RF 2016 0236407011,504,7511a) Theory enhancing.

3 Repositioning of Niacin/Nicotinic acid for the therapy of CMT neuropathies with focal hypermyelinationSAN RAFFAELE MILANO18,5012,52,5222RF 2016 023612469,007,5012a) Theory enhancing:Precision medicine to study and prevent metabolic adverse effects induced by second generation antipsychotic drugs: pharmacogenetic profiling in patients and mechanistic analysis of the effect of genetic variants in vitroLombardia18,7511,51,522,753RF 2016 023637616,509,25 Pagina 2 di 94 Bando Ricerca Finalizzata 2016 Graduatoria Sezione Ordinaria RFCriteri Sub RankingRANKC odiceProgettoTipo RicercaTitolo ProgettoDISCORE FINALER ispondenza RilenvanzaQualit ScientificaChiarezza e AppropiatezzaTrasferibilit nel SSNCVS core Impatto ) Theory enhancing:Identification of new biomarkers for Oligoarticular Juvenile Idiopathic Arthritis by exosomal miRNA assessment in blood and synovial fluid GASLINI19,0011,5222,54RF 2016 023610487,008,0014b) Change promoting:Design of new personalized therapeutic approaches for diffuse large B cell lymphomaEmilia Romagna19,00112,52,52,754RF 2016 023637307,008,0015a) Theory enhancing:Impact of different treatment strategies on clonal evolution in multiple myelomaEmilia Romagna19,0012,5322,52RF 2016 023625329,507,5016a) Theory enhancing:Randomized phasE 2 study of Valproic acid in combination with bevacizumab and Oxaliplatin/fLUoropyrimidine regimens in patients with ras mutated metastaTIc cOlorectal caNcer (REVOLUTION trial)PASCALE19,0013331,51RF 2016 0236331412,006,0017a) Theory enhancing:Development of an Italian clinical/diagnostic network focused on the prevention and management of virologic failures in hepatitis C virus (HCV) patients treated with direct antivirals agents (DAAs)Sicilia19,0021,5222,52RF 2016 023624227,0010,0018a) Theory enhancing.

4 Dissecting the link between pulmonary stromal changes and lung cancer progression for biomarkers discovery and therapeutic interventionISTITUTO TUMORI MILANO19,00222223RF 2016 023629468,008,0019a) Theory enhancing:Translational genetics of hereditary dysmyelinating disorders of the central nervous system: deep phenotyping, NGS strategies, and model organisms for clinical diagnosis and identification of novel disease genesCARLO BESTA19,2511,52,51,53,52RF 2016 023612857,0010,25 Pagina 3 di 94 Bando Ricerca Finalizzata 2016 Graduatoria Sezione Ordinaria RFCriteri Sub RankingRANKC odiceProgettoTipo RicercaTitolo ProgettoDISCORE FINALER ispondenza RilenvanzaQualit ScientificaChiarezza e AppropiatezzaTrasferibilit nel SSNCVS core Impatto ) Theory enhancing:Interplay between gut microbiota and adaptive immunity in Amyotrophic Lateral Sclerosis: a clinical trialEmilia Romagna19,2512,52,52,52,53RF 2016 023616169,007,2521a) Theory enhancing:Mitophagy and autophagy in the ischemic brain: a new target to promote neuroprotectionSAN RAFFAELE MILANO19,2512323,251RF 2016 023615718,509,7522b) Change promoting:Anti nerve reactivity as predictor of response to immune therapy in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)HUMANITAS19,5011,521,51,57RF 2016 023618877,505,0023a) Theory enhancing:Efficacy assesment of new targeted combination therapies for muscoloskeletal sarcomas as the basis for tailoring patient's treatmentRIZZOLI19,5012222,54RF 2016 023613738,007,5024a) Theory enhancing:Adoptive immunotherapies with regulatory and conventional T cells and/or Natural Killer cells: safe and effective strategies to minimize the risk of leukemia relapse after allogeneic hematopoietic stem cell ,5011,52,52,523RF 2016 023643838,008,5025c) Change promoting.

5 Basic requirements and preliminary studies for a program of prevention of diabetes type 2 in ,00122223RF 2016 023645138,508,5026b) Change promoting:Impact of whole exome sequencing on the clinical management of patients with advanced nonalcoholic fatty liver and cryptogenic liver disease MAGGIORE20,00122231RF 2016 023643588,0011,0027b) Change promoting:First in human Italian Phase I II Trial based on adoptive Chimeric Antigen receptor (CAR) T cells specific for GD2 antigen in patients with high risk neuroblastoma. OSPEDALE BAMBINO GESU'20,00222,52,531RF 2016 023643889,0010,00 Pagina 4 di 94 Bando Ricerca Finalizzata 2016 Graduatoria Sezione Ordinaria RFCriteri Sub RankingRANKC odiceProgettoTipo RicercaTitolo ProgettoDISCORE FINALER ispondenza RilenvanzaQualit ScientificaChiarezza e AppropiatezzaTrasferibilit nel SSNCVS core Impatto ) Theory enhancing:MUSE: understanding the Mechanisms Underlying the Selection and spread of carbapenem resistant Enterobacteriaceae in intensive care units.

6 A multicenter clinical epidemiological study coupled with molecular ,50132,5314RF 2016 0236458410,506,0029a) Theory enhancing:Combined electroclinical and morpho functional analysis for the identification, definition, and surgical removal of the human epileptogenic zone in drug resistant patientsCARLO BESTA20,50132,53,51,55RF 2016 0236219511,004,5030a) Theory enhancing:Lipid metabolism network as a target to overcome resistance in melanomaISTITUTO TUMORI MILANO20,75122,532,753RF 2016 023610919,508,2531a) Theory enhancing:Addressing residual challenges of HCV infection in the era of Direct Acting Antiviral (DAAs) therapies : co morbidities, gender differences, universal access. Translation of clinical findings from large national cohorts into health care ,751,52,53,53,52,53RF 2016 0236405311,006,7532a) Theory enhancing:Role of the adipokine visfatin in inflammation and metabolic syndromesHUMANITAS20,75222,523,51RF 2016 023648428,5011,2533a) Theory enhancing:Transition metal ions as a new therapeutic target for cardiac light chain MATTEO21,00122136RF 2016 023617566,009,0034a) Theory enhancing:Multimodal nanotracking for exosome based therapy in DMDMAGGIORE21,001,522,5244RF 2016 023622638,009,0035a) Theory enhancing.

7 Circulating levels of hydrohen sulfide (H2S) as a novel marker of bone turnover in postmenopausal osteoporosis and agingToscana21,001,51,531,53,253RF 2016 023622387,5010,50 Pagina 5 di 94 Bando Ricerca Finalizzata 2016 Graduatoria Sezione Ordinaria RFCriteri Sub RankingRANKC odiceProgettoTipo RicercaTitolo ProgettoDISCORE FINALER ispondenza RilenvanzaQualit ScientificaChiarezza e AppropiatezzaTrasferibilit nel SSNCVS core Impatto ) Theory enhancing:Molecular and functional analysis of patient derived glioblastoma stem like cells to identify new biomarkers and actionable targets for innovative therapeutic approachesIstituto Superiore di Sanita'21,5011,5224,54RF 2016 023610897,0010,5037b) Change promoting:PET/CT imaging for evaluating early response to novel androgen receptor targeted agents in castration resistant prostate cancer patientsEmilia Romagna21,5011,52,52,53,54RF 2016 023648098,509,0038a) Theory enhancing:Exploiting targeted epigenetic editing to increase efficiency and safety of oligodendroglial progenitor cell (OPC) generation from human iPSC: implications for cell therapy of RAFFAELE MILANO21,501,521,52,542RF 2016 023624048,0011,5039a) Theory enhancing:Effect of HIV 1 Tat in the establishment and maintenance of the virus reservoiresIstituto Superiore di Sanita'21,501,51,52,52,53,252RF 2016 023647448,0011,5040a) Theory enhancing:Osteopontin molecular network as regulator of autoimmunity related lymphomagenesis and specification of ABC DLBCL phenotypeISTITUTO TUMORI MILANO21,503221,534RF 2016 023641217,0010,5041c) Change promoting:Geriatric vs.

8 Traditional Emergency Departments: a prospective evalUation of Patients outcomes and healthcare costs (the GED UP study). ,751,51,752,5224RF 2016 023629288,009,7542a) Theory enhancing:EVIDENCE BASED REVISION OF THE INTERNATIONAL LEAGUE AGAINST RHEUMATISM (ILAR) CLASSIFICATION CRITERIA FOR JUVENILE IDIOPATHIC ARTHRITISGASLINI21,751,523,5233RF 2016 023640088,5010,2543a) Theory enhancing:Investigating the molecular mechanism leading to genome instability in tumors: analysis of role of the replication stress response and its potential for early diagnosis and target therapy of cancerIstituto Superiore di Sanita'22,0011224,755RF 2016 023620226,5010,50 Pagina 6 di 94 Bando Ricerca Finalizzata 2016 Graduatoria Sezione Ordinaria RFCriteri Sub RankingRANKC odiceProgettoTipo RicercaTitolo ProgettoDISCORE FINALER ispondenza RilenvanzaQualit ScientificaChiarezza e AppropiatezzaTrasferibilit nel SSNCVS core Impatto ) Theory enhancing:miR 200 family: a pharmacologic target in diabetic foot ulcer treatmentISTITUTO DERMOPATICO DELL'IMMACOLATA22,0013,5212,56RF 2016 023627087,508,5045a) Theory enhancing.

9 Identification of novel genetic risk factors located in the conserved haplotype region surrounding the LCT locus on chromosome ,00122,53,533RF 2016 023632469,509,5046a) Theory enhancing:All trans retinoic acid in the neo adjuvant treatment of estrogen receptor positive breast cancer patients: a window of opportunity trial aimed at confirming the efficacy of the retinoid and at evaluating the diagnostic potential of a gene expression moMARIO NEGRI22,0012,52,52,534RF 2016 023623839,508,5047a) Theory enhancing:A genetically determined hyper Th17 syndrome with reduced allograft survivalSAN RAFFAELE MILANO22,0012,52,53,533RF 2016 0236251211,507,5048d1) Theory enhancingInnovative one day molecular methods to evaluate the compliance of European Regulation microbiological criteria in Food. (Acronym one day method)Istituto Superiore di Sanita'22,00132,5341RF 2016 0236400211,0010,0049a) Theory enhancing:HMGB1 and its designer versions as master regulators of tissue healingSAN RAFFAELE MILANO22,001242,532RF 2016 0236302411,009,0050a) Theory enhancing:An integrated platform for molecular studies and clinical trials in myelodysplastic syndromesHUMANITAS22,0022,53,5331RF 2016 0236491811,0010,0051a) Theory enhancing:Exploring genome/phenome interaction in Multiple SclerosisCASA SOLLIEVO SOFFERENZA22,251221,753,256RF 2016 023612947,508,7552a) Theory enhancing.

10 Exploiting the co and post transcriptional regulation of gene expression as therapeutic tool for human cancerSANTA LUCIA22,251,53323,254RF 2016 0236346010,008,25 Pagina 7 di 94 Bando Ricerca Finalizzata 2016 Graduatoria Sezione Ordinaria RFCriteri Sub RankingRANKC odiceProgettoTipo RicercaTitolo ProgettoDISCORE FINALER ispondenza RilenvanzaQualit ScientificaChiarezza e AppropiatezzaTrasferibilit nel SSNCVS core Impatto ) Theory enhancing:A strain based comprehensive strategy to reveal human prion diseases potentially linked to animal prionsIstituto Superiore di Sanita'22,5012,52,5333RF 2016 0236449810,509,0054a) Theory enhancing:Insight into new therapeutic preclinical strategies in Autosomal Recessive Spastic Ataxia of Charlevoix Saguenay typeSTELLA MARIS22,501333,52,53RF 2016 0236161011,508,0055a) Theory enhancing:Innovative therapeutic strategy targeting neurons with cholesterol in Huntington Disease: from preclinical studies to clinical trial readiness MARIO NEGRI22,50133,53,52,51RF 2016 0236192812,009,5056a) Theory enhancing:Toward a genetic and pathogenesis driven classification and treatment of primary membranoproliferative glomerulonephritis MARIO NEGRI22,5014443,51RF 2016 0236172014,007,5057a) Theory enhancing:Dissection of new pathways linking renal sodium handling and hormonal control of blood pressure.