MMB - kuraray

1 MMB3-Methoxy-3-Methyl-1-ButanolKashimaTo kyoIn 1972 kuraray developed a new isoprene synthesis process by combining C4and C1, thisnew process and another new synthetic rubberprocess provided kuraray the incentive to build a new plant for these materials in at a glance Air Freshener Electrical, Fan, Car type, Reed diffuser, Gel, Household Cleaner Kitchen, Air fan, Toilet, Bathroom, Floor, Multi Industrial Cleaner for Electronic, PCB, Optical, Metal parts, Precision Dry Soap Hand Cleaner Insecticide and Pesticide Ink and CoatingMMB(3-Methoxy-3-Methyl-1-Butanol) The main reasons why using MMB kuraray s KASHIMA FACILITY in Japan is under a strict quality control based on ISO-9001and toxicity AmphipathicGood solubilizerMild odor To control evaporation speedStable versus autoxidation High Flash point BiodegradableFaible toxicit AmphiphileBonne propri t de solubilisationFaible odeurPermet un bon contr le de la vitessed vaporationStable l auto-oxydationPoint clair lev Bonne biod gradabilit Geringe Toxizit tAmphipatischGutes L severm gen Geruchsarm Konstantes Verdampfungsverhalten Stabil gegen ber AutoxidationHoher Flammpunkt Biologisch abbaubarBaja toxicidad AnfipaticoBuena solubilidadBajo olorPara controlar la velocidad de evaporaci nEstable frente a la oxidacionAlto Punto de inflamaci n BiodegradableSpecification of MMBA ppearanceClear and Colorless LiquidColor (APHA)10maxSpecific Gravity (20 C /20 C) - (760mmHg) IBP ( C)

2 168minDP ( C)178maxAcidity as acetic acid (Wt %) (%) on PlasticsPlasticsVolume % vs Initial*Rigid PVC8 Soft PVC9 Polyethylene (Low Density)0 Polyethylene (High Density)0 Polypropylene0 Polystyrene19 Polycarbonate0 Polyacetal0 PET0 PBT0 Polyphenylene Sulfide06-Nylon06,6-Nylon0 Teflon 0 Epoxy Glass0 Acrylic ResinPartially DissolvedPhenol Resin0 ABS63 Properties of MMBP hysical PropertiesFormulaC6H14O2=118 Specific Gravity (@ 20 C / 20 C) (@ 20 C) s7. 3 5cpsBoiling Point (@ 760mmHg, 101 kPa)174 C 345 FHeat of Vaporization (@ )384 Point< -50 CFlash Point (Tag's CC)68 C 154 FLog Pow(@ 25 C) in WaterINFINITES olubility (cal/cm3)1/2 Hansen Solubility (MPa)1 (MPa)1/2 Hydrogen (MPa)1 (MPa)1/2 Specific Electric Conductivity (@ 20 C) 10-7 -1cm-1 Vapor Density (air=1) Index (@ 20 C) Tension (@ 20 C) Pressure (@ 20 C) Rate (n-BuAc=100)7 Explosion Range - vol %Ignition Point395 C 743 FDilution Ratioa) Toluene (NC,1/2sec) ) Toluene (Epoxy resin) ) Xylene (NC, 1/2sec) on ElastomersElastomersVolume %vs Initial*Fluoro rubber Viton 82 Chloroprene Rubber64 Butyl Rubber0 Nitrile Rubber115 Silicone Rubber6 Ethylene Propylene Rubber7 Natural Rubber17 Urethane Rubber129 SBR26*Volume increase % of test specimen (50x20x2mm)after soaked in MMB at 50 C for 7 (days)

3 510152025 15010050 Stability in Alkali Condition/pH=10 Experimental:MMB (50g) and Carbonatebuffer solution pH = (50g) were placedin a bottle and capped. The bottle was kept 50 C for 4 weeks. Residual ratio wasmeasured by GC analysis. MMB is one of the fruits of our intensivedevelopment effort for novel products which are bio mimetic and at the same time friendlier to our environment and less harmful to living organisms. Ethylene oxide based Glycol ether -2 Ethylene oxide based Glycol ether -1 Propylene oxide based Glycol etherMMBS tability against AutoxidationExperimental:Solvent (150g ) was placed in a beaker. Temperature was kept 18 C to 22 C. POV of each solvent was measured for 3weeks by iodometric (as H2O2, ppm)time (weeks)start1234100 %Stability in Acidic Condition/pH=4 Experimental: MMB (50g) and Phthalatebuffer solution pH = (50g) were placedin a bottle and capped. The bottle was kept 50 C for 4weeks.

4 Residual ratio wasmeasured by GC analysis. Quantitativeanalysis with GC(residual %) time (weeks)start1234100 %Quantitativeanalysis with GC(residual %) MMBMMBCH3H3 COCH3 CCH2CH2 OHSafety Data of MMB1. Acute Oral ToxicityLD50: / kg (rats)1LD50: / kg (mice)22. Inhalation Toxicity after repeated dose2(rats /500ppm /28days)No significant changes were observed in the pathological,historical and functional examinations of viscera but a slight increase in GOT activity in liver and a slight increase in kidney weights as percentages of body weight. Other abdominal viscera showed nothing wrong in Mutagenicity1(Reversion test with bacteria / Ames test)No evidence of mutagenic potential4. Teratogenicity3 Developmental NOEL: 500mg / kg - rat / dayMaternalNOEL: 250mg / kg - rat / dayMMB is not a development toxicant, because there were no adverse effects on development at either of two dosagesthat were not toxic to the Acute Dermal Toxicity in Rats4LD50: >2,000mg / kgNo deaths occurred and no clinical signs were noted after24 h dermal administration, under occlusion of MMB at adose level of 2,000mg / kg.

5 6. Skin sensitization potential4 Negative responses noted in all test and control group animals following challenge with MMB at concentration of 100%.7. Primary Skin Irritation in Rabbits4 MMB is non-irritant to rabbit skin under the test conditions. Mean irritation scores: MMB100% v/v in distilled slight erythema was noted at one test site treated withMMB at a concentration of 100% at the 24 h assessment Dermal Irritation in Rabbits (28 day repeat)4 MMB100% (slightly irritant)MMB50% v/v in distilled Photo-irritation potential in Guinea Pigs4No photo-irritant responses were noted in the test and control Photosensitisation potential in Guinea Pigs4 None of the test group animals showed a positive Human Skin Patch Test548h male & female : negative12. Primary Eye Irritation in Rabbits5 MMB is moderately irritant to rabbit eyes, however, rinsing 30-60s after instillation with distilled water reduces the irritation potential of MMB.

6 The non-rinsed eyes showedsome responses, and returned to normal by 9-10days Life Sciences, Industrial Safety Association, Japan3 Argus Research Laboratory Inc., Research International, Mouhatsu Kagaku Kyokai, JapanMMB is a clear, colorless, low toxic watermiscible liquid. In addition to MMB, kuraray also produces, Diols, Diamine andPesticide raw materials. 1. Acute Toxicity for fish1(Killfish, 48hrs JIS K -0102 55)TLm :7, 4 0 0ppm2. Biomagnification in fish1(carp, 8 weeks)No magnification3. Biodegradability2 MMB is biodegradable, in accordance with ISO 14593(adopted March 1999), OECD 310(adopted March 2006). This test designed to meet the requirements of EC 648/2004(amended by EC 907/2006), and EPA OPPTS (adopted January 1998)4. Chemical Oxygen Demand (COD)38,060mg / L (1% aqueous solution of MMB)References1 Chemicals Inspection & Testing Institute, Japan2 Huntingdon Life Sciences Ltd, , 20083 Japan Oil Stuff Inspectors Corporation, Inc.

7 , JapanRegulatory StatusCAS Number56539-66-3 AICS (Australia)ListedCRC-SEPA (China)ListedDSL (Canada)ListedECL (Korea)Listed KE-24367 EINECS (EU)Listed 260-252-4 ENCS (Japan)Listed 2-3079 NZIoC (New Zealand) ListedPICCS (Philippine)ListedSWISS (Switzerland)Listed G-117002 TSCA (USA) ListedREACHPre-registered( kuraray Europe GmbH has intention to register MMB in REACH as an importer)INCI Name: MethoxymethylbutanolPackaging16kg (35lbs) in can *185kg (407lbs) in drum890kg (1962lbs) in IBC in ISO container*available in Europe and JapanEnvironmental Effect of MMBK uraray Co., Marketing & Sales DepartmentTokyo Head officeOte Center Building, 1-1-3, OtemachiChiyoda-ku, Tokyo, 100-8115 JapanPhone +81-3-67 01-16 23 Telefax +81-3-67 01-16 Europe GmbHPhilipp-Reis-Stra e 4,65795 Hattersheim am Main, GermanyPhone +49-69-30 53 58 44 +33-156-45 12 51 Telefax +49-69-30 59 83 58 kuraray America, Area Boulevard, Suite 600 Houston, Texas 77058-1151, USAP hone+1-713-495-73 25 Telefax+1-713-495-73 the best of our knowledge, information contained herein is accurate.

8 It is the sole responsibility of the customer to determine whether the product is appro-priate and suitable for customer s specific use. Specific end use may require approval by appropriate regulatory agencies. All chemicals may present unknownhealth hazards and should be used with caution. Although certain hazards may be described in this publication, we cannot guarantee that these are the onlyhazards that exist. kuraray makes no warranties, express or implied, regarding products on any information contained here in. kuraray disclaims any liabilityfor infringement of any patent by reason of customer s use of any kuraray products in combination with other materials or in any process. 04 / 2012