特にNAFLD/NASHについて

1 nafld /NASH B C NASH) F F0 F1 F2 F F4F4 F4F1 CT nafld /NASH nafld nonalcoholic fatty liver disease NAFL nonalcoholic fatty liver NASH nonalcoholic steatohepatitis nafld NASH NASH 5 20 NASHNAFLD NAFL5 10 nafld NASH nafld NASH nafld /NASH NAFLD2266 NASH376 NASH66 nafld 70 nafld 40 nafld 20 nafld 40 110 729-734 2021 nafld NASH Case

2 ALT, AST AST/ALT 1 HOMA-IR CRP NASH nafld 2010 ~ nafld /NASH nafld /NASH 2020 nafld /NASH PNPLA3 nafld NASH PNPLA3GG 20 PNPLA3 G PNPLA3G nafld /NASH nafld /NASH 2020 PNPLA3 nafld /NASH nafld /NASH 2020 3 1 1 nafld ~ ~ nafld /NASH nafld /NASH 2020 C 60/1000 nafld

3 NASH C nafld /NASH nafld /NASH 2014 nafld /NASH nafld NASH nafld 109 47 55 2020 nafld NASH nafld /NASH nafld 10 NASH nafld nafld /NASH 3 nafld /NASH nafld /NASH NAFL NASH Matteoni NASH 2014:114:25-34 Gold standard nafld /NASH nafld /NASH AST 109/L ALT Fib4 index Fib4 Fib4 Fib4 website + BMI / AST/ALT 109/L nafld fibrosis score NFS website Fibroscan nafld /NASH nafld /NASH 2020 nafld /NASH nafld /NASH 2020 70kg 5kg nafld /NASH nafld /NASH 2020 nafld /NASH

4 QOL NASH nafld nafld QOL nafld nafld /NASH nafld /NASH 2020 nafld nafld 30-40 4 12 nafld QOL nafld Gastroenterology 2021;160:912 918 nafld ( BMI 25 BMI 23) 3-5% 1200 1500 kcal/d 500 1000 kcal/d nafld NASH nafld /NASH NASH SGLT2 GLP-1 ARBACE E ENAFLD/NASH nafld NAFL NASH nafld /NASH