National Dose Banding Table Single Container

1 1 | N a t i o n a l D o s e B a n d i n g T a b l e s 1 0 m g / m L V e r s i o n 4 1 D e c 2 0 1 6 National dose Banding Table Single Container Strength of raw material (after reconstitution if required) 10 mg/mL Example drug(s) Cabazitaxel Carboplatin Dacarbazine Docetaxel Thiotepa Vinorelbine See Table usage notes below regarding Single Container and multiple syringe tables. Master Bands and Ranges This Table is intended to be in a format useful for electronic prescribing systems. Use To (A) if your system will round UP for doses on the step between two bands. Use To (B) if your system will round DOWN for doses on the step between two bands.

2 The dose range is designed to cover drugs which may be added in the future. Band Range (mg) Band dose (mg) Variance (percent) From To (A) < To (B) Below Above 8 5 -6 9 6 -5 10 5 -5 11 5 -4 12 4 -4 13 4 -4 14 4 -3 15 4 -3 16 3 -3 17 3 -3 18 3 -5 20 5 -5 22 5 -4 24 4 -4 26 4 -4 28 4 -3 30 4 -3 32 3 -3 34 3 -3 36 3 -5 40 5 -5 44 5 -4 48 4 -6 54 6 -5 60 5 -5 66 5 -6 74 6 -5 82 5 -5 90 5 -5 100 5 -5 110 5 -4 120 4 -4 130 4 -4 140 4 -3 150 4 -3 160 3 -6 180 6 -5 200 5 -5 2 | N a t i o n a l D o s e B a n d i n g T a b l e s 1 0 m g / m L V e r s i o n 4 1

3 D e c 2 0 1 6 Band Range (mg) Band dose (mg) Variance (percent) From To (A) < To (B) Below Above 220 5 -4 240 4 -6 270 6 -5 300 5 -5 330 5 -4 360 4 -5 400 5 -6 450 6 -5 500 5 -6 560 6 -6 630 6 -5 700 5 -6 790 6 -6 890 6 -6 1000 6 -6 1130 6 -6 1280 6 -6 1450 6 -6 1640 6 -6 1850 6 -6 2090 6 -6 2360 6 -6 2670 6 -6 3000 6 -6 3380 6 -6 3820 6 -6 3 | N a t i o n a l D o s e B a n d i n g T a b l e s 1 0 m g / m L V e r s i o n 4 1 D e c 2 0 1 6 Drug- and dose -specific Tables These tables are intended to assist with non-electronic systems where protocol-specific

4 Information is required. The range of the tables has been extended beyond normal use, especially in the lower ranges, to allow for up to a 50% dose reduction to be used in patients who are Doses which are normally capped are highlighted in grey. Carboplatin in 250-1,000mL glucose 5% GFR RANGES USED IN PRACTICE ARE NARROWER THAN PRESENTED HERE AUC GFR (from) 2 GFR (to) dose 90 100 110 120 130 140 150 160 180 200 220 240 270 300 330 360 400 450 500 560 AUC GFR (from) GFR (to) dose 110 120 130 140 150 160 180 200 220 240 270 300 330 360 400 450 500 560 630 700 AUC GFR (from) 3 GFR (to)

5 dose 140 150 160 180 200 220 240 270 300 330 360 400 450 500 560 630 700 790 890 1000 AUC GFR (from) 4 GFR (to) dose 180 200 220 240 270 300 330 360 400 450 500 560 630 700 790 890 1000 1130 1280 1450 AUC GFR (from) GFR (to) dose 200 220 240 270 300 330 360 400 450 500 560 630 700 790 890 1000 1130 1280 1450 1640 AUC GFR (from) 5 GFR (to) dose 220 240 270 300 330 360 400 450 500 560 630 700 790 890 1000 1130 1280 1450 1640 1850 AUC GFR (from) 6 GFR (to) dose 270 300 330 360 400 450 500 560 630 700 790 890 1000 1130 1280 1450 1640 1850 2090 2360 AUC GFR (from) 7 GFR (to)

6 dose 330 360 400 450 500 560 630 700 790 890 1000 1130 1280 1450 1640 1850 2090 2360 2670 3000 4 | N a t i o n a l D o s e B a n d i n g T a b l e s 1 0 m g / m L V e r s i o n 4 1 D e c 2 0 1 6 AUC GFR (from) 8 GFR (to) dose 360 400 450 500 560 630 700 790 890 1000 1130 1280 1450 1640 1850 2090 2360 2670 3000 3380 Cabazitaxel in 250mL sodium chloride over 1 hour via a micron filter (60mg vials) BSA Choose nearest for dose reductions 25 mg/m2 15 16 17 18 20 22 24 26 28 30 32 36 36 40 44 44 48 48 54 54 60 60 60 66 66 74 74 74 Dacarbazine in 500mL sodium chloride over 1 hour (100mg, 200mg, 500mg and 600mg vials)

7 BSA Choose nearest for dose reductions 375 mg/m2 180 200 220 240 270 300 330 360 400 450 500 500 560 630 630 700 700 790 790 790 890 890 890 1000 1000 1000 1130 1130 Docetaxel in 100 1,000mL glucose 5% BSA Choose nearest for dose reductions 35 mg/m2 22 24 26 28 30 32 34 36 40 44 44 48 54 54 60 66 66 74 74 74 82 82 90 90 90 100 100 110 40 mg/m2 24 26 28 30 32 34 36 40 44 48 54 54 60 66 66 74 74 82 82 90 90 100 100 100 110 110 120 120 75 mg/m2 36 40 44 48 54 60 66 74 82 90 100 110 110 120 130 140 140 150 160 160 180 180 180 200 200 220 220 220 100 mg/m2 48 54 60 66 74 82 90 100 110 120 130 140 150 160 180 180 200 200 220 220 240 240 240 270 270 270 300 300 Thiotepa in a final concentration of 5mg/mL in glucose 5% (typical volumes 8-20mL)

8 Via a micron filter (15mg and 100mg vials) BSA Choose nearest for dose reductions 30 mg/m2 17 18 20 22 24 26 28 30 34 36 40 44 44 48 54 54 60 60 66 66 66 74 74 82 82 82 90 90 40 mg/m2 24 26 28 30 32 34 36 40 44 48 54 54 60 66 66 74 74 82 82 90 90 100 100 100 110 110 120 120 5 | N a t i o n a l D o s e B a n d i n g T a b l e s 1 0 m g / m L V e r s i o n 4 1 D e c 2 0 1 6 Vinorelbine in 50mL sodium chloride over 5-10 min (note that doses are usually capped at except for 20mg/m2 used in IGEV lymphoma protocol) BSA Choose nearest for dose reductions 15 mg/m2 8 9 10 11 12 13 14 15 17 18 20 22 22 24 26 28 28 30 30 30 30 30 30 30 30 30 30 30 20 mg/m2 12 13 14 15 16 17 18 20 22 24 26 28 30 32 34 36 40 40 44 44 48 48 48 54 54 54 60 60 25 mg/m2 15 16 17 18 20 22 24 26 28 30 32 36 36 40 44 44 48 48 48 48 48 48 48 48 48 48 48 48 30 mg/m2 17 18 20 22 24 26 28 30 34 36 40 44 44 48 54 54 60 60 60 60 60 60 60 60 60 60 60 60 Table usage notes: Single Container tables are for products which are able to be supplied as a Single unit, such as an infusion bag, one syringe, or as an infusor device (pump).

9 Multiple syringe ( pick-and-mix ) tables are for products which are supplied in combinations of syringes to make up a Single dose . Some drugs may have both a Single Container Table , and a multiple syringe Table . Doses may vary between the two tables due to rounding requirements. Chemotherapy dose Standardisation