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NHL & CLL –Diagnosis and Treatment Update

1 NHL & CLL diagnosis and Treatment UpdateChristopher R. Flowers, MD, MSSeptember 13, 2012 Slide 1: NHL & CLL diagnosis and Treatment UpdateOPERATOR: hello , everyone , and welcome to NHL and CLL diagnosis and Treatment Update , a free telephone webeducation program. It is my pleasure to introduce your moderator Lauren Berger of The Leukemia &Lymphoma 2: welcome and IntroductionLAUREN BERGER:Thank you and hello and hola to everyone . On behalf of The Leukemia & Lymphoma Society, a warmwelcome to all of you. And our special thanks to Dr. Christopher Flowers for sharing his time and expertisewith us are proud to offer this program in collaboration with Abrale, our partner organization in Brazil, and AlianzaLatina of Latin d also like to acknowledge and thank Genentech and Biogen Idec for their grant to bring this

Hello, everyone, and welcome to NHL and CLL –Diagnosis and Treatment Update, a free telephone web education program. It is my pleasure to introduce your moderator Lauren Berger of …

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Transcription of NHL & CLL –Diagnosis and Treatment Update

1 1 NHL & CLL diagnosis and Treatment UpdateChristopher R. Flowers, MD, MSSeptember 13, 2012 Slide 1: NHL & CLL diagnosis and Treatment UpdateOPERATOR: hello , everyone , and welcome to NHL and CLL diagnosis and Treatment Update , a free telephone webeducation program. It is my pleasure to introduce your moderator Lauren Berger of The Leukemia &Lymphoma 2: welcome and IntroductionLAUREN BERGER:Thank you and hello and hola to everyone . On behalf of The Leukemia & Lymphoma Society, a warmwelcome to all of you. And our special thanks to Dr. Christopher Flowers for sharing his time and expertisewith us are proud to offer this program in collaboration with Abrale, our partner organization in Brazil, and AlianzaLatina of Latin d also like to acknowledge and thank Genentech and Biogen Idec for their grant to bring this program Leukemia & Lymphoma Society is pleased to support this program as a continuing education opportunity.

2 Before we begin, I would like to introduce Merula Steagall, President of Abrale and member of Alianza Latinasteering committee. welcome , STEAGALL: hello , everyone . On behalf of Abrale, the Brazilian Leukemia & Lymphoma Society, I would like to thank TheLeukemia & Lymphoma Society of the United States for once again enabling the Brazilian patients, as wellpatients from other countries in South America, to have access to this important program and receive themost up-to-date information about chronic lymphocytic leukemia and non-Hodgkin s our establishment in 2002.

3 The Leukemia & Lymphoma Society has been a great inspiration to us anda huge support for the improvement of all our would like also to thank Dr. Flowers for sharing his knowledge with us. And we are sure that by the end ofthe program all of us will have a better understanding of how to diagnose and treat non-Hodgkin s lymphomaand chronic lymphocytic thank you all for participating and for the opportunity. And a warm heart to all of you from BERGER:Thank you, d also like to introduce The Leukemia & Lymphoma Society s President and CEO, John Walter, who will sharea few words.

4 John?2 NHL & CLL diagnosis and Treatment UpdateChristopher R. Flowers, MD, MSSeptember 13, 2012 JOHN WALTER:Thank you, Lauren. I would also like to add my welcome to all the patients, caregivers, healthcare professionalson the program today. We are fortunate to have as our presenter Dr. Christopher Flowers. We appreciateDr. Flowers s dedication to supporting the mission of The Leukemia & Lymphoma Society through his researchand care of patients with blood cancer. I would like to thank him for taking the time out of a busy schedule toprovide us with an Update on NHL and CLL diagnosis and Leukemia & Lymphoma Society is committed to bringing you the most up-to-date information about yourblood cancer.

5 We know it is important for you to stay current, so that you can work with your healthcare teamto determine the best options for the best vision is that one day the great majority of people who have been diagnosed with a blood cancer will becured or they will manage their illness with good quality of life. Since 1954 LLS has awarded more than $875million to fund research, specifically targeting blood cancers. We will continue to invest in research for curesand programs and services and improve the quality of life for patients and families. This program is one stepon the road of your journey to managing your life with NHL or you, and I ll turn the program back over to BERGER:Thank you, this time I am privileged to introduce Dr.

6 Christopher Flowers, Associate Professor of Hematology andMedical Oncology at the Winship Cancer Institute at Emory University School of Medicine in Atlanta, you so much, Dr. 3: Christopher R. Flowers, MD, MSDR. CHRISTOPHER FLOWERS:Thank you, Lauren, and thank you to The Leukemia & Lymphoma Society and to Abrale and Alianza Latina forputting together this program. and welcome and thank you to all of you who have joined us and Lauren mentioned, I m Dr. Christopher Flowers, Associate Professor at Winship Cancer Institute, and I havethe privilege of talking to you today from Emory University in Atlanta, and talking to you about the 4: Anyone can get blood cancerAs many of you are well aware, anyone can get blood cancer.

7 And there are over a million individuals in NorthAmerica who are affected each year by blood are shown here are data from the United States, looking at the estimated number of new cancer casesthat occur. And divided by the type of cancers. And you can see in the yellow for the non-Hodgkin lymphomas,and the leukemias, including chronic lymphocytic leukemia, that these cancers represent approximately thefifth and seventh most common cancers in males and females, although these numbers vary from year to3 NHL & CLL diagnosis and Treatment UpdateChristopher R.

8 Flowers, MD, MSSeptember 13, 2012year. And together represent more than a million individuals who are affected each year, both in terms of newdiagnoses with cancer and ongoing battles with 5: Lymphomas/Chronic Lymphocytic Leukemia Today I will spend time talking about some forms of non-Hodgkin s lymphomas and chronic lymphocyticleukemia. The lymphomas and CLL in general are cancers of the cells of the immune system. Shown here at the right ofthis slide is a cartoon that shows in green lymph nodes and chains within the lymph system, and other organsthat are highly involved with the lymph system, including the GI tract and the bone marrow and the lymphomas and chronic lymphocytic leukemia are classified by the source of cancer cells and I will showyou in a few slides some examples of the vast majority of lymphomas and CLL, the causes of these cancers are unknown.

9 These are cancersthat usually start in the lymph nodes, but they can involve any of the other tissues mentioned, including thespleen, the skin, the GI tract, the liver, the bone marrow or other sites. And oftentimes these can start in thelymph nodes and then eventually spread to one or more of these 6: Common SymptomsThis patient, who is a patient from my clinic, or an example of a patient from my clinic, exhibits some of thecommon symptoms that can be seen with the lymphomas and chronic lymphocytic leukemia. This is a 63-year-old gentleman who was feeling reasonably well until over the last three months he started to feel muchmore worn down and tired, and eventually was so tired that he was unable to go to work.

10 Over the sametime period, he noted that he was starting to have sweats at night and sweats to the point where he wassoaking his clothes and needing to change his pajamas. At that same time he was losing weight and lostapproximately 17 pounds over the three month had noted a lump in his groin over that time period and noticed over that time period that that lumpcontinued to get larger and larger. And by the time he came to see me, he also noticed that he was havinga lump under his left arm in his armpit and in his left neck. And noted over the last several days that he wasstarting to feel itchy all 7: Common Symptoms (cont d) Many of these symptoms that he described are common symptoms associated with the lymphomas.


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