有機スズ化合物の生殖発生毒性 - nihs.go.jp

1 Table 1. CAS Dibutyltin dichloride683-18-110,000 - 15,000 Dibutyltin dilaurate77-58-71000 - 5000 Dibutyltin maleate78-04-6500 - 1000 Dibutyltin oxide818-08-61000 - 5000 Dibutyltin bis 2-ethylhexylmercap-acetate 10584-98-27,500 - 12,500 Dibutyltin bis isooctyl mercap-acetate 25168-24-5 Not availableDimethyltin dichloride753-73-11,000 - 5,000 Dimethyltin bis 2-ethylhexyl mercap-acetate 57583-35-45,000 - 10,000 Dimethyltin bis isooctyl mercap-acetate26636-01-1 Not availableDioctyltin dichloride3542-36-75,000 - 10,000 Dioctyltin bis 2-ethylhexyl mercap-acetate 15571-58-17,500 - 12,500 Dioctyltin bis isooctyl mercap-acetate 26401-86-5 Not availableMonobutyltin trichloride1118-46-310,000-15,000 Monobutyltin tris 2-ethylhexyl mercap-acetate 26864-37-92,500-7,500 Monobutyltin tris isooctyl mercap-acetate 25852-70-4 Not availableMonomethyltin trichloride993-16-81,000 - 5,000 Methyltin Reverse Ester Tallate201687-57-27,500 - 10,000 Monomethyltin tris 2-ethylhexylmercap-acetate 57583-34-35,000 - 10,000 Monomethyltin tris isooctylmercap-acetate 54849-38-6 Not availableMono-octyltin trichloride3091-25-61,000 - 5,000 Mono-octyltin tris 2-ethylhexylmercap-acetate 27107-89-72,500 - 7.

2 500 Mono-octyltin tris isooctylmercap-acetate 26401-86-5 Not availableTributyltin chloride1461-22-92500 - 3000 Tetrabutyltin1461-25-210,000 - 12,500 Tetraoctyltin3590-84-92,500 - 7,500 Tin Tetrachloride7646-78-820,000 - 25,000 ORTEP Association. 2004. Global production data35 Reproductive and Developmental Toxicity of Organotin CompoundsMakoto Sci.,125, 35-50 (2007)Review Organotin compounds are chemicals widely used in agriculture and industry. Widespread use of organotins has caused increasing amounts to be released into the environment. Organotins show many aspects of toxicity, such as immunotoxicity, neurotoxicity, and reproductive/developmental toxicity.

3 However, the reproductive and devel-opmental toxicity of organotins is not well understood. The fi ndings of the studies on reproductive and develop-mental effects of organotin compounds in mammals were summarized in this : Organotin, reproductive toxicity, developmental toxicity, implantation failure, teratogenicityTo whom correspondence should be addressed:Makoto Ema; Kamiyoga 1-18-1, Setagaya, Tokyo 158-8501, Japan; Phone: +81-3700-9878; Fax: +81-3-9700-1408; E-mail: 1 2 TPT TBT PVC PVC Table 1 PVC 3 4 5-7 8-12 TBT TPT 13 14 15 16 17 TBT 36 125 2007 10 18 TPT TBT 1

4 G 1991 , g 1992 TPT 1 g 1991 g 1992 19 1998 1 TPT: g DPT : 0 g TBT: g DBT : g 19 FAO/WHO TPT 1 25 g 20 tributyltin oxide TBTO 18 g 21 11 19 Belfoid 2000 9 TBT 22 TBT TPT 23 imposex: 24 2 21 25-28 Ema M and Hirose A 2006 29 Reproductive and developmental toxicity of organotin com-pounds In Metals Fertility and Reproductive Toxicity CRC Press 2 2-1 TPT TPT 30 Table 2 TPT 100 200 ppm triphenyltin hydroxide TPTH 64 Sharman 5 31 Holtzman 20 mg/kg triphenyltin acetate TPTA triphenyltin chloride TPTCl

5 19 TPTA 32 20 mg/kg TPTA TPTCl Holtzman 20 70 33 ICR/Ha Swiss TPTA ,12 mg/kg TPTH , mg/kg TPTA 6mg/kg TPTH 11 mg/kg 5 13 34 TPT 20 mg/kg TPTA TPTCl Holtzman 4 35 TPTCl 36 Wistar 0-3 , , mg/kg 4-6 , , mg/kg TPTCl 0-3 mg/kg 4-6 mg/kg 0-3 mg/kg TPTCl TPTCl 37 38 37 / 37-41 TPTCl Wistar 42 0-3 TPTCl mg/kg 4 11:00 13.

6 00 9 43 4 9 mg/kg 0-3 Table 2 ( ) TPTH Sharman 100-200 ppm 64-238 Gains & Kimbrough (1968) / TPTA Holtzman 20 mg/kg 19 Pate & Hays TPTCl (1968) TPTA Holtzman 20 mg/kg 20 Snow & Hays TPTCl (1983)

7 TPTA ICR/Ha Swiss mg/kg 1 Epstein et al. 6 mg/kg 5 (1972) TPTH mg/kg 1 11 mg/kg 5 TPTA Holtzman 20 mg/kg 4-24 Newton & Hays TPTCl (1968) TPTCl Wistar mg/kg 0-3 , Ema et al.

8 (1997a) mg/kg 4-6 TPTCl Wistar mg/kg 0-3 Ema et al. (1999a) DPTCl Wistar mg/kg 0-3 , Ema et al. (1999b) mg/kg 4-7 , DPTCl Wistar mg/kg 0-3 Ema & Miyawaki (2002) TPTH: Triphenyltin hydroxide, TPTA: Triphenyltin acetate, TPTCl: Triphenyltin chloride, DPTCl: Diphenyltin dichloride.

9 37 36 TPTCl TPTCl TPTCl TPTCl mg/kg TPTCl TPTCl 44 TPTCl TPTCl 2-2 DPT TPT DPT MPT 45-47 DPT Table 3 Diphenyltin dichloride DPTCl 48 DPTCl Wistar 0-3 mg/kg 4-7 mg/kg 0-3 mg/kg 4-7 mg/kg 0-3 48 mol /kg 4-7 mg/kg DPTCl 0-3 DPTCl TPTCl mg 12 mol /kg 49 TPTCl DPTCl DPTCl TPTCl TPT DPTCl 47 DPT TPT DPT TPT DPT DPTCl Wistar 0-3 mg/kg DPTCl mg/kg 4 9 50 0-3 48 DPTCl Table 3 ( )

10 TPTA Wistar 5-15 mg/kg 6-15 , Giavini et al. (1980) TPTA Wistar 9-12 mg/kg 7-17 , Noda et al. (1991a) TPTA CFY 6 mg/kg 6-14 , Lehotzky et al (1982) TPTA THA 4-8 mg/kg