NTI Meds to be Closely Monitored when Co-Administered …

1 NTI Meds to be Closely Monitored when Co-Administered with CannabinoidsPennsylvania State University, College of Medicine, Dept of Pharmacology Therapeutic Index (NTI) Medication Enzyme/Metabolism acenocoumarol (VKA)CYP1A2, CYP2C9, CYP2C19, CYP3A4alfentanilCYP3A, CYP3A4aminophyllineCYP1A2, CYP3A4amiodaroneCYP1A2, CYP2C8, CYP2C19, CYP3A4amitriptylineCYP1A2, CYP2B6, CYP2C19, CYP3A4amphotericin BProtein Binding (PB)argatrobanCYP3A4busulfanCYP3A4carbam azepineCYP1A2, CYP3A4, UGT2B7clindamycinCYP3A4clomipramineCYP1A 2, CYP2B6, CYP2C19, CYP3A4, UGT2B7clonidineCYP1A2, CYP3A4clorindione (VKA)CYP3A4cyclobenzaprineCYP1A2, CYP3A4cyclosporineCYP3A4dabigatran etexilateUGT1A9, UGT2B7desipramineCYP1A2, CYP2B6dicoumarol (VKA)CYP2C9digitoxinCYP3A4dihydroergotam ineCYP3A4diphenadione (VKA)CYP3A4dofetilideCYP3A4dosulepinCYP2 B6doxepinCYP1A2, CYP2C9, CYP2C19, CYP3A4ergotamineCYP3A4esketamineCYP2B6, CYP3A4ethinyl estradiol ( oral Contraceptives)UGT1A9, UGT2B7ethosuximideCYP2E1, CYP3A4ethyl biscoumacetate (VKA)CYP3A4everolimusCYP3A, CYP3A4fentanylCYP3A4fluindione (VKA)

2 CYP2C9, CYP3A4fosphenytoinCYP2C8, CYP2C9, CYP2C19, CYP3A4imipramineCYP1A2, CYP2B6, CYP2C19, CYP3A4levothyroxineCYP3A4lofepramineCYP2 B6melitracenCYP2B6meperidineCYP2B6, CYP3A4mephenytoinCYP1A2, CYP2C19 While every attempt was made to provide the most comprehensive list of potential drug-drug interactions, there may be medications not included in this of 2 List Updated April 13, 2020 NTI Meds to be Closely Monitored when Co-Administered with CannabinoidsPennsylvania State University, College of Medicine, Dept of Pharmacology Therapeutic Index (NTI) Medication Enzyme/Metabolism mycophenolic acidUGT1A9, UGT2B7nortriptylineCYP1A2, CYP2B6, CYP3A4paclitaxelCYP2C8, CYP3A4phenobarbitalCYP2C19phenprocoumon (VKA)CYP2C8, CYP2C9, CYP3A4phenytoinCYP2C8, CYP2C9, CYP2C19pimozideCYP1A2, CYP3A, CYP3A4propofolUGT1A9quinidineCYP2C9, CYP2E1, CYP3A4sirolimusCYP3A, CYP3A4tacrolimusCYP3A, CYP3A4temsirolimusCYP3A4theophyllineCYP1 A2, CYP3A4thiopentalCYP2C19tianeptineCYP3A4t rimipramineCYP2B6valproic acidCYP2C9, UGT1A9, UGT2B7warfarin (VKA)CYP1A2, CYP2C9, CYP2C19, CYP3A4 Legend.

3 (VKA) vitamin K AntagonistWhile every attempt was made to provide the most comprehensive list of potential drug-drug interactions, there may be medications not included in this of 2 List Updated April 13, 2020