認知症の要因と予防 - nuas.ac.jp

1 7 2015 1 65 400 2030 600 E C D n- 3 DHA EPA 1-4 5 6 NILS-LSA 9 7 40 7 4 12 4 2,267 22 24 7 7 25 MMSE wais -R-SF wais WMS-R I II NILS-LSA 4 65 3,000 1 30 15 14 16 4.

2 898 MRI PET 1970 18 2008 2008 3 6 2009 2010 7 65 1 1 2 MRI 2008 2008 65 2,822 406 NILS-LSA 7 8 2 60 80 24 1 2010 65 415 2020 535 2030 643 20 5 66 86% 3 7 10 8 5 9 9 -12 19 2

3 (NILS-LSA) 8 65 70 75 80 2 NILS-LSA 8 4 NIA 75 7 10 85 3 13 1991 APP APP 20 14 1995 1 PS1 15 PS1 2 PS2 APP PS1 PS2 1993 Strittmatter E4

4 3 16 E4 1 / 3 E4 E4 APP PS1 PS2 17 E4 2 18 3,000 Syst-Eur 19 30 20 Kungsholmen 65mmHg 21 160mmHg 15mmHg 22 18 5 23 Framingham 24 25 C CRP IL - 1 IL-1 IL6 TNF- 2- 1- 26

5 Helicobacter pylori 27 3 20 3 C wais -R HbA1c E wais -R 3 C wais -R HbA1c E wais -R 6C C E 28.

6 29 E C 30 NILS-LSA 1 3 3 C wais -R E 31 32 D 25-OH D D 33 34 3 5 8 18 8 68 23 A 16 7 E 4 35 C 5 2 2 n- 6 n- 3 n-6 - n3 - EPA DHA DHA EPA - DHA DHA EPA 7 n- 3 65 Chicago Health and Aging Project 7 60 n- 3 DHA

7 36 5,000 Rotterdam Study 60 70 37 DHA EPA RCT 38 MCI 39 NILS-LSA DHA DHA wais -R IQ 4 n- 6 DHA MCI DHA MCI 40 3 C A B6 Chicago Health and Aging Project 6 40 41 n- 3

8 21 4 DHA 4 DHA 8 Rotterdam study 37 LDL HDL 42-44 3,000 30 Honolulu Heart Program 45 46 Women s Health Initiative Memory Study WHIMS 7,479 65 MCI 47 4 48 38 49 5 U 50 51 250ml 500ml 6 52

9 53 NILS-LSA 5 wais -R 1 9 4 6 7 47 8 48 5 6 wais -R Z Mean=0, SD= 10 54 2 2 6 65 2 33 2,000 7.

10 700 55 2 15 10 5 2 2 1