1 NUT026 Rev. 6/98. CLINICAL NUTRITION INSIGHTS. Copyright 1997 Advanced Nutrition Publications, Inc. Nutritional Support for Connective Tissue Repair and Wound healing BY DR. MARK PERCIVAL. ABSTRACT: Tissue Repair and wound healing are complex substance. When there is damage to Connective Tissue it is processes that involve a series of biochemical and cellular important to address the Nutritional requirements for the reactions, beginning with inflammation and followed by the synthesis of both the collagen fibers and the proteoglycans. Many Repair and remodeling of the injured Tissue .
2 While damage to nutrients are involved in Connective Tissue Repair and wound Connective Tissue was once believed to be irreparable, there is healing : glucosamine sulfate, D-glucuronic acid, amino acids, now scientific evidence to the ,2 Connective Tissue bioflavonoids, and select vitamins and minerals. In addition to Repair and remodeling involves chondrocyte reproduction and Nutritional Support , homeopathy has been used for generations activity and the formation of collagen fibers and ground for both acute and chronic injuries. Immediately following an injury, the healing process begins.
3 A has the capacity to both heal and regenerate. The degree of Repair torn ligament or muscle is repaired, wounds heal, bones mend. The and regeneration of the IVD is greatly dependent on the character of healing process first involves getting rid of damaged Tissue , then the extracellular scaffold,' the available nutrition, the age, and the rebuilding healthy Connective Tissue in a step-by-step manner. The biomechanical state of the diskal material ten case studies are redness, swelling, heat, and pain of inflammation are a natural part of presented that clearly demonstrate thepossibility of reversing the healing process.
4 Prolonged or excessive inflammation, however, osteoarthritic degeneration of the spine. Before and after radiographs may slow down the healing process, which may cause continued loss of these ten case histories providedevidence of various types of of function and discomfort. On the other hand, total elimination of improvement including disk height increases, decreases in inflammation from massive drug treatment may also result in delayed osteophyte formation, reinitiation of thenormal cervical curvature, and a reduction of disk instability. The time interval necessary for improvement to manifest varied from as little as two months to over An appropriate inflammatory response is a vitally important seven years, and was dependent on the degree of compliance to part of Tissue Repair and wound healing , and deserves greater a multifaceted regime and the extent of the degeneration, among attention than is provided here.
5 The inflammatory process, muscle other things. spasm, and related Nutritional Support are addressed in the Clinical Nutrition Insight titled, Understanding the Natural Management of OSTEOARTHRITIS REVERSAL MAY BE POSSIBLE. Pain & Inflammation. The focus here relates to the Repair and remodeling phase of the healing process, specifically that of Osteoarthritis has the highest morbidity of all illnesses affecting Connective Tissue . While damage to Connective Tissue was once mankind. The cause of severe pain and compromised joint function, believed to be irreparable, there is now scientific evidence to the osteoarthritis often leaves patients confined to bed or a ,2 Chondrocytes the cells responsible for the formation, Until recently, osteoarthritis has been looked upon as an irreversible maintenance, and Repair of articular cartilage were long thought to consequence of aging, the inevitable result of continuous wear and be incapable of reproducing and forming new Tissue .
6 Current tear on the joints. But with increasing knowledge of the factors evidence suggests they are much more responsive to mechanical, contributing to osteoarthritis, these and other beliefs about the endocrine, biochemical, and microenvironmental stimuli than was disease, and about Connective Tissue in general, are beginning to previously ,3 change. Indeed, there is some clinical and experimental evidence In a well-referenced article by Ressel,2 clinical and experimental that suggests the possibility that the degenerative process of evidence indicates that cartilage damaged by trauma, injury, or osteoarthritis may be stopped and even kinesiopathology may heal either with identical Tissue or a mixture of fibrocartilage and hyaline cartilage.
7 He states, Clinical and experi- Another misconception is that conditions of joint degeneration mental evidence is overwhelming that the IVD (intervertebral disk) require complete immobilization to Support the healing process. On 1. the contrary, continued use and weight bearing may be necessary for keratan sulfates and, to a lesser degree, dermatan sulfates. As articular Findings from some immobilization studies suggested by their names, sulfur is a major component of GAGs have been summarized by Navarro and Sutton4 as follows: (except for hyaluronate). The sulfurization of GAGs imparts a high negative charge density.
8 GAGs thus repel each other, causing a Degeneration changes in cartilage appear after ten days space-filling function. The negativity and space allow for great water of immobilization. absorption and retention, which accounts for the high degree of There are cumulative degenerative changes from periodic compressibility characteristic of Connective Tissue . It is the gel-like immobilizations as brief as four days in duration at four week proteoglycans that give Connective Tissue its compressional strength intervals. and ,5. Immobilization (periodic or continuous) over 30 days leads to progressive osteoarthritis.
9 Elastins are highly cross-linked proteins similar to collagens, and are found in Connective tissues such as ligaments, skin, and large Return to normal use and weight bearing after three weeks blood vessels. Elastins give various Connective tissues rubber band- of immobilization reverses the effects of immobilization. like elasticity and resiliency. As with collagen, one-third of the Excessive mechanical stress after three weeks of immobilization amino acid residues are glycine. Elastin is also rich in proline but, accelerates cartilage degeneration. unlike collagen, it contains no hydroxylysine and very little Because articular cartilage is an avascular Tissue , its chondrocytes do not receive a steady supply of nutrients directly GUIDELINES FOR Connective Tissue Repair .
10 From a capillary bed as do other tissues. Nutrients must, in effect, be absorbed into the cartilage much like water is absorbed into a The following guidelines for Connective Tissue Repair is a sponge. An adequate supply of nutrients surrounding, or bathing, synopsis taken from published articles by leading experts on the collagen must be present for the delivery of the nutrients to the Connective Tissue research:2,4. chondrocytes. Alternating compression and decompression of the Provide thorough consultation and exam. Tissue is what facilitates the delivery. Thus, blending comprehensive Nutritional Support with proper joint motion and the appropriate weight Design specific corrective procedures to restore normal bearing exercise may serve a physiologic function necessary for articular function and optimize neurological integrity delivery of nutrition to the cartilage and recovery of cartilage Tissue and function.