ON-LINE ICU MANUAL

1 ON-LINE ICU MANUAL The target audience for this ON-LINE MANUAL is the resident trainees at Boston Medical Center. The goal is to facilitate learning of critical care medicine. In each folder the following items can be found: 1. Topic Summary 1-2 page handout summary of the topic. This is written with a busy, fatigued resident in mind. Each topic summary is designed for use in conjunction with the relevant didactic lecture given during the rotation. 2. Original and Review Articles Original, and review articles are provided for residents who seek a more comprehensive understanding of a topic.

2 We recognize that residency is a busy time, but we hope that you will take the time to read articles relevant to the management of your patients. 3. BMC approved protocols For convenience BMC approved protocols, when available, are included in relevant folders. This MANUAL is just one component of the ICU educational curriculum. In order to facilitate learning at many levels, several other educational opportunities are available. These include: 1. Didactic lectures Essential core topics in critical care medicine will be introduced during each ICU rotation.

3 Many, but not all, of the topics addressed in this MANUAL will be covered. 2. Tutorials These are 20-30 minute sessions offered during the rotation that will provide the resident with hands on experience ( mechanical ventilators, ultrasound devices, procedure kits). 3. Morning rounds Housestaff are expected to take ownership of assigned patients. The goal of morning rounds is to develop treatment plans that can be defended by the best available scientific evidence. In addition, morning rounds are an opportunity for residents to test their knowledge, gauge their progress in critical care education, and recognize the limits of the current medical practice.

4 The faculty and fellows of Boston University Pulmonary and Critical Care section hope that you enjoy your rotation in the medical intensive care unit. 1 BOSTON MEDICAL CENTER ICU MANUAL 2008 By Allan Walkey Ross Summer 2 Table of Contents Chapters on Oxygen Delivery Devices, Airways and Mechanical Ventilation A. Oxygen Delivery Devices and Goals of Oxygenation / Literature B. Modes of Mechanical Ventilation / Literature C. Acute Respiratory Distress Syndrome and Ventilator-Associated Lung Injury / Literature D.

5 Discontinuing Mechanical Ventilation / Literature E. Noninvasive Mechanical Ventilation / Literature F. Management and Optimal Timing of Tracheostomy / Literature Chapters on Cardiopulmonary Critical Care G. How to Read a Portable CXR / Literature H. Acid Base Disorders / Literature I. Treatment of Severe Sepsis & Shock: Part I (Fluids and Antibiotics) / Literature J. Treatment of Severe Sepsis & Shock: Part II (Steroids, Glucose, Xigris) / Literature K. Vasopressor & Inotropic Therapy / Literature L. Venous Thromboembolism: Prophylaxis and Treatment / Literature M.

6 Sedation and Analgesia Paralytics / Literature N. Diagnosis and Management of Delirium Tremens / Literature O. Pneumonia: Community-Acquired, Nosocomial and Ventilator-Associated Pneumonia / Literature P. Asthma and COPD: Treatment / COPD Literature Asthma Literature Q. Nutrition in the ICU / Literature R. Ischemic Stroke / Literature S. Subarachnoid Hemorrhage / Literature T. Seizures / Literature U. Hypertensive crisis / Literature V. Prognosis after Anoxic Brain Injury and Diagnosis of Brain Death / Literature W. Management of Severe Electrolyte Abnormalities / Literature X.

7 Renal Replacement Therapy / Literature Y. Acute Pancreatitis / Literature Z. Gastrointestinal Bleeding and Massive Transfusion / Variceal Literature, nonvariceal AA. Compartment Syndromes / Literature BB. Massive Hemoptysis / Literature CC. Shock and Advanced Hemodynamic Monitoring / Literature DD. Hypothermia and Hyperthermia / Literature EE. Toxicology / Literature FF. Carbon Monoxide, Cyanide and Methemoglobin Toxicity GG. Diabetic Ketoacidosis and HHNK / Literature HH. End of Life Care / Literature II. ACLS / Literature JJ.

8 Anaphylaxis / Literature KK. Blood Products in the ICU / Literature 3LL. Miscellaneous: Acute Chest Syndrome / Acute Chest Literature Cardiac Biomarkers in ICU Lit. Fulminant Hepatic Failure/ Literature Stress Ulcer prophylaxis MM. PA Catheter and Pulmonary Hypertension / Literature 4A. Oxygen Delivery Devices and Goals of Oxygenation I. Oxygen cascade: Describes the process of declining oxygen tension from atmosphere to mitochondria. At sea level, atmospheric pressure is 760mmHg. Oxygen makes up 21% of atmospheric gases (760mmHg x ) so the partial pressure of oxygen in the atmosphere is 159mmHg.

9 During respiration air is humidified reducing atmospheric pressure by 47mmHg to 713mmHg so the maximal inspired partial pressure of oxygen is 149mmHg. Once air enters the lungs it meets up with carbon dioxide, which further dilutes oxygen concentration (see alveolar air equation, part VI). Therefore, the maximal oxygen concentration in the alveolar space depends on barometric pressure, the fraction of oxygen in inspired air, and the concentration of CO2 in the alveolar space. II. Causes of low blood oxygen. a. Atmospheric causes i.

10 Decreased fraction of inspired oxygen. ii. Decreased barometric pressure b. Cardiopulmonary causes i. V/Q mismatch ii. Shunt iii. Diffusion defect iv. Decreased cardiac output III. Oxygen carrying capacity a. [ x Hb x (SaO2/100)] + x PO2 b. Oxygen is carried in blood in two forms. i. Bound to hemoglobin (largest component) - Each gram of hemoglobin can carry of oxygen. Hemoglobin has 4 binding sites for oxygen, and if all are occupied then the oxygen capacity would be saturated. Under normal conditions, the hemoglobin is 97% to 98% saturated.