OPERATIONS MANUAL THRESHOLD LIMIT VALUES (TLV ) …

1 1 OPERATIONS MANUAL THRESHOLD LIMIT VALUES (TLV ) FOR CHEMICAL SUBSTANCES COMMITTEE LAST REVISED: 07-NOV-2020 3640 Park 42 Drive Cincinnati, Ohio 45241 513-742-2020 the Science o f Occupational and Environmental Health 2 TABLE OF CONTENTS PAGE Committee Membership Member Member Responsibilities and Membership Member Emeritus Membership Service William D. Wagner Committee Organizational Position TLV-CS Committee TLV-CS Committee TLV -CS Subcommittee TLV -CS Subcommittee 9 Administrative Subcommittee Description of Administrative Steering Membership Notations Chemical Selection Conflict of TLV Production TLV Development Voting TLV Documentation Literature The Use of Non-Peer Reviewed External to the Within the Between the Committee, Staff and Board of Symposia and Procedure for Developing a Symposium or APPENDIX 1: TLV Documentation Guidelines.

2 21 ANNEX A, TLV Documentation TLV Documentation Selecting an Appropriate TLV ..35 TLV Documentation ANNEX B, TLV Basis 3 ANNEX C, Conversions and ANNEX D, PART 1, ANNEX D, PART 2, Sensitization (DSEN/RSEN)..56 ANNEX D, PART 3, Inhalable Fraction and Vapor (IFV)..67 ANNEX D, PART 4, ANNEX D, PART 5, Ototoxicity (OTO)..71 ANNEX D, PART 6, TLV -SL (Surface LIMIT )..78 APPENDIX 2: Literature Search Process Finding Chemical and Physical APPENDIX 3: Committee Organizational 4 THRESHOLD LIMIT VALUES (TLV ) FOR CHEMICAL SUBSTANCES COMMITTEE Committee Mission The THRESHOLD LIMIT value for Chemical Substances (TLV -CS) Committee is appointed by the Board of Directors of ACGIH to develop occupational exposure guidelines for chemical substances. The issuance of THRESHOLD LIMIT VALUES (TLVs ) and their supporting Documentation is the principal mechanism for the dissemination of these guidelines, although the Committee may also develop more general positions, instructional materials, educational media, or topical symposia to focus on issues of concern.

3 This Committee s vision is to be a respected, worldwide leader in the development and dissemination of health-based occupational exposure guidelines. Specifically, the mission of the TLV -CS Committee is to recommend airborne concentrations of agents and exposure conditions for use in the practice of industrial hygiene and by other qualified professionals to protect worker health. The charge of the TLV -CS Committee is to develop and disseminate occupational exposure guidelines ( , TLVs ). TLVs are based on the best available data and, whenever possible, peer-reviewed literature on human health effects resulting from industrial, occupational or other exposure situations; from experimental human and animal studies with support from in vitro studies; human epidemiological studies; and when possible, from a combination of all these sources. The goal of the Committee is to develop occupational exposure guidelines for chemical substances that are: Scientifically credible Well-supported ( , TLVs are based on ACGIH s review of peer-reviewed scientific literature and robust data summaries) Scientifically valid Reliable Understandable and clear Produced with a balanced, unbiased and clearly-defined process, free of conflicts of interest The TLV -CS Committee operates under the Bylaws of ACGIH and the administrative policies and procedures approved by the ACGIH Board of Directors.

4 Membership Eligibility The Committee will consist of individuals representing the disciplines necessary for establishing TLVs ( , industrial hygiene, occupational medicine, occupational epidemiology, and toxicology). A range of professional affiliations is necessary to ensure a balance of disciplines; however, the Committee will consist of a simple majority of members professionally affiliated with academia or government. Committee members serve in their individual capacity and do not serve as representatives of their organization or employer. Each member of the Committee will have full voting rights for the purposes of the business of the Committee. Committee leadership (Committee Chair and Vice-Chair) must be Voting Members of ACGIH. A Voting Member of ACGIH shall be a professional who currently spends greater than 50% of his or her employment in the field of Occupational and Environmental Health and Safety, a professional who has retired from employment that involved greater than 50% of his or her time in the field of Occupational and Environmental Health and Safety, or a full-time student officially matriculated in an undergraduate or graduate program in environmental health, occupational health and safety or related discipline.

5 5 Member Selection Individuals interested in joining the TLV -CS Committee will be asked to complete an application and provide a current resum or curriculum vitae. The Membership Subcommittee will review the application and determine whether the applicant is eligible and has qualifications that fit the current needs of the Committee. This process is described in detail in the Membership Subcommittee section. The following criteria will be used to evaluate an applicant for membership: Relevant training and education Professional background Past relevant experience Personal attributes necessary to meet committee goals The following criteria will be used to assess the overall membership of the Committee and whether a particular applicant fits with the committee s activities: The Committee should have a mix and balance of persons who have expertise in one or more of the following: industrial hygiene, occupational medicine, epidemiology, toxicology or other related specialties ( , statistics, chemistry, etc.)

6 Preference will be given to individuals with 10 or more years of professional experience and with advanced degrees in their field of expertise. Indi viduals should demonstrate competence in writing and communication through publications, presentations or other activities. The membership should reflect the diversity of the industrial hygiene and occupational health field. Preference will be given to individuals with multi-disciplinary backgrounds and experience or strength in a particular field. Member Responsibilities and Expectations Each member of the TLV -CS Committee, with the exception of the Chair, will be assigned to a TLV -CS subcommittee (Dusts and Inorganic Compounds; Hydrogen, Oxygen and Carbon Compounds; Miscellaneous Compounds). TLV -CS Committee members are expected to prepare and review Documentation for TLV -CS chemical substances.

7 The expected number of TLV Documentation prepared and reviewed annually may vary for individual members, depending on other activities they undertake that serve the committee s priorities. In addition to chemical substance subcommittee activities, each member of the Committee is encouraged to participate on at least one administrative subcommittee ( , Notations, Membership). Individual members will coordinate their activities with their respective subcommittee Chairs, with review by the TLV -CS Committee Chair. TLV -CS Committee members are expected to contribute to the work of the Committee. This includes time spent annually attending face-to-face meetings, preparing and reviewing TLV Documentation, and participating in administrative subcommittee activities. More senior members are expected to provide guidance and mentorship to new members.

8 Members are expected to comply with all Policies and Procedures of ACGIH . At all times, m embers are expected to interact in a collegial fashion with other members of the TLV -CS Committee and staff. Participation on the Committee is a privilege that must be continually earned, through on-going productivity, participation, and collegial behavior. When considering re-appointment, the Chair will review a member s participation in light of membership expectations and length of tenure on the Committee. As members serve additional terms, they are expected to take on a greater role with in the Committee, which may include preparing additional Documentation, chairing a chemical substance or administrative subcommittee, and other activities as needed. It is essential that Committee Members regularly attend Committee meetings, participate in all scheduled conference calls, and prepare and review Documentation.

9 6 Membership Terms Members are annually appointed by the Board of Directors and begin their term on January 1. The TLV -CS Committee Chair will consult with the appropriate TLV -CS Subcommittee Chairs/Vice Chairs and other members of the Committee prior to recommending re-appointment. Expectations for continuing membership include, at a minimum: Attendance at and constructive contributions to meetings; Participating in scheduled conference calls; Satisfactory progress in completing assignments, including but not limited to preparing and reviewing Documentation. It is expected that each member will complete at least one new and one revised document each year. Member Candidates The TLV -CS Committee may choose to invite potential members to participate in committee activities, including authoring one or more TLV Documentation ( , completing Doc update(s)), as member candidates before recommending them for formal appointment.

10 This practice allows the potential member to understand the role of committee members and allows the Committee to evaluate the potential member. The Board of Directors must appoint individuals before they become member candidates. Member candidates do not have voting privileges for purposes of committee business but are expected to participate. The default expectation is that member candidates are to complete at least one new and one revised document during their probation period, attend all meetings of the Committee, and participate fully in committee discussions. Member candidates must follow all ACGIH policies and procedures. Consultants Periodically the TLV -CS Committee may need specific technical expertise and may utilize the help of volunteer consultants to fill that void. Consultants are identified and vetted in a similar fashion as member candidates and nominated by the TLV-CS Committee Chair for review and appointment by the ACGIH Board of Directors.