Oxyhemoglobin Dissociation Curve - CRNA Board Preparation ...

1 Oxyhemoglobin Dissociation CurveCoreNotesby Core Concepts Anesthesia Review, LLC1. The P50is the PO2at which hemoglobin is 50% The normal P50is 27 The P50reflects the affinity of hemoglobin for Elevated P50values indicate that hemoglobin will surrender oxygen to the tissuesmore Elevated P50values indicate a right shift of the Causes of an elevated P50value include: acidosis, hyperthermia, increased PCO2and increased 2, The Bohr Effect states that oxygen is more readily released by hemoglobin in theface of acidosis or Oxyhemoglobin Dissociation Curve illustrates the affinity of hemoglobin for loading of oxygen onto the hemoglobin molecule is minimally altered by changes inthe P50.

2 However, the release of oxygen to the tissues is profoundly affected by the rightward shift of the Curve (shown in red) is reflected by an elevation in the P50andthis improves delivery of oxygen to the tissues. A rightward shift is seen with: acidosis,hypercarbia, hyperthermia, increased 2,3-DPG and hemoglobin S. A leftward shift(shown in green) is seen with: alkalosis, hypocarbia, hypothermia, decreased 2,3-DPGand hemoglobin ,3-DPG (2,3-diphosphoglycerate) is present in RBCs and reduces hemoglobin s affinityfor oxygen. 2,3-DPG levels are increased with chronic hypoxemia and anemia; levelsprogressively decrease during the storage of Reading:Miller, RD, Pardo, of Anesthesia. Philadelphia: Elsevier, 2011:56-57, 519