Transcription of p005-010 抗血栓療法ガイドライン 総論-02
1 2 5. 2 .. A . 1 .. A2 1 .. 7 10 60 325 mg .. A2 2 g .. neuraxial block .. neuraxial block . ADP.. P2Y12 . G PLA2.. COX. ATP cAMP 5 -AMP. TXA2.. Ca 2 .. GPIIb/IIIa .. 1 . 6 . 2 . ADP P2Y12 ADP . GTP cAMP .. 1 . P2Y12 .. 7 10 . B . 1 . K . K K II. VII IX X . 1 . 1 .. VII 6 8 . IX 24 . X 25 60 . II 50 80 . VII IX . II . PT-INR .. PT-INR prothrombin time-international normal- 20 ized ratio 50 .. K . P2C9 .. K .. 2 . 5,000 20,000 Xa .. 2 7.. Xa . Xa 2 .. 45 60 .. Xa IIa AT.. Xa 2 . IIa . AT AT) . IIa .. Xa .. Xa . IIa AT Xa .. Xa . 3 . 4,000 6,000 .. Xa . 2 . Xa . 60 2 4 . Xa 3 5 . Xa 12 .. 30 50 ml min . 4 . 6,000.
2 Xa . 20 1 20 . 8 . DIC . DIC disseminated intravas- HIT cular coagulation HIT .. HIT heparin-induced thrombocytopenia 5 .. X. Xa 2 .. 2 . 14 17 .. 6 K .. 2 Xa .. Xa . Xa . Xa . Xa Xa . Xa . Xa . 2 . Xa .. Tmax 3 2 4 1 4 1 2 . 80 100 49 50 .. P gp CYP3A4 CYP3A CYP3A . P gp P gp P gp . 35 92 95 87 40 59 . 12 14 8 11 8 15 9 11 . 80 66 25 40 . 2 9.. Xa . 3 . 3 .. 2 4 4 6 6 .. 22 26 26 30 .. 6 4 6 4 6 .. 35 . 80 .. Levy 1 .. 2 6 . 22 30 . 4 6 . 4 Idestrup 2 .. 504 . 20 . C Congestive heat failure 1. LV dyafunction 15. H hypertention 1. A age 75 year 75 1. 10 D Diabetes mellitus 1. 5 S2 Stroke TIA 2 TIA . 0. 0 6 0 1 2 3 4 5 6.
3 CHADS2 . 4 CHADS2 2 . 10 . 20 .. 75 50 ml . min . 50 kg .. 1 Levy JH, Faraoni D, Spring JL, et al : Managing new oral anticoagulatnts in the perioperative and intensive care unit setting. Anesthesiology 2013 ; 118 : 1466-1474. 2 Idestrup C, Sawhney M, Nix C, et al : The incidence of hematoma forma- tion in patients with continuous femoral catheters following total knee arthroplasty while receiving rivaroxaban as thromboprophylaxis: An ob- servational study. Reg Anesth Pain Med 2014 ; 39 : 414-417.
