ことばの遅れのある子どもへ ... - park3.wakwak.com

1 2013/9/9 1 ADHD .. 2013/9/9 2 .. ! 2013/9/9 3

2 2013/9/9 4 or PECS PECS

3 2013/9/9 5 PECS 2013/9/9 1 ADHD AD/HD Motivation AD/HD AD/HD or PDD ADHD-RS M-CHAT PARS CBCL SDQ ADHD-RS TRF ADHD-RS 16 11 1 2 3 4 ( CBCL ) ( CBCL ) 2013/9/9 2 Strengths and Difficulties Questionnaire : SDQ.

4 1 0 1 2 2 0 1 2 3 0 1 2 4 0 1 2 5 0 1 2 6 0 1 2 7 2 1 0 8 0 1 2 9 0 1 2 10 0 1 2 11 2 1 0 12 0 1 2 13 0 1 2 14 2 1 0 15 0 1 2 16 0 1 2 17 0 1 2 18 0 1 2 19 0 1 2 20 0 1 2 21 2 1 0 22 0 1 2 23 0 1 2 24 0 1 2 25 2 1 0 Low Need Some Need High Need exact% exact% exact% Total Difficulties 0 12 13 15 16 40 0 3 4 5 10 0 3 4 5 10 0 5 6 7 10 0 3 4 5 10 6 10 5 0 4 SDQ (4-12 , 2899 )

5 Low Need Some Need High Need [1] [2] [3] [4] [5] Total Difficulties Score [1] [4] OROS-methylphenidate AD/HD 76 100% 63 1 3 2 5 3 5 13 n=76 1) 6 15 70 5 cm 2) kg 2) 38 27 3 7 11 2 15 mg/kg/d n=63 mg/kg/d kg 1 2013/9/9 3 OROS-MPH ADHD-RS -20-18-16-14-12-10-8-6-4-20 n=63 -25-20-15-10-50 n=55 ** ** ** ** ** ** **: p< vs baseline (paired t-Test) OROS-MPH ADHD-RS -25-20-15-10-5030 (n=37) 21-29(n=13)20 (n=13) -30-25-20-15-10-5030 (n=37) 21-29(n=10)20 (n=9) ** ** ** ** **: p< vs baseline, **:p< (paired t-Test) SDQ n=60 051015202530 TotalDifficultiesScore ** ** **:p< , **:p< , *.

6 P< (paired t-Test) ** ** * ** 0510152025 TotalDifficultiesScore SDQ n=48 ** ** ** * **:p< , **:p< , *: p< (paired t-Test) * CBCL T n=67 0102030405060708090100 ** ** ** ** ** ** ** ** ** **:p< , **:p< , *: p< (paired t-Test) 0102030405060708090100 ** TRF T n=60 ** * **: p< , **: p< , *:p< (paired t-Test) * ** ** ** * ** 2013/9/9 4 Atomoxetine AD/HD 150 100% 65 85 108 1 19 2 23 42 Mean SD 70 5 25 (kg) (mg) Mean SD (mg/kg) n=163 (mg)

7 ADHD-RS -25-20-15-10-50 n=82 -25-20-15-10-50 n=83 ** ** ** ** ** ** **: p< vs baseline (paired t-Test) ADHD-RS -25-20-15-10-5030 (n=44) 21-29(n=21)20 (n=17) n=82 -25-20-15-10-5030 (n=44) 21-29(n=21)20 (n=18) n=83 ** ** ** ** **: p< vs baseline (paired t-Test) CBCL T n=77 0102030405060708090100 ** ** **: p< , +: p< (paired t-Test) ** ** ** ** ** ** ** ** 2013/9/9 5 150 30 6 6 6 4 4 2 2 1 1 1 33 I: Kratochvilet al.

8 J Am Acad Child Adolesc Psychiatry2002;41(7):776 784. II :Sangal et al. Sleep 2006;29(12):1573 1585. III: Wang et al. Aust N Z J Psychiatry 2007;41(3):222 230. IV:Newcorn et al. Am J Psychiatry2008;165(6):721 730. ADHD RS I*p=.02 (ANCOVA)p=.16 (ANCOVA)p=.43 (ANOVA)p=.66 (ANCOVA) II III IV0-5-10-15-20-25 OROS , , . , , . 24 .. ,OFF , , AD/HD , OROS-MPH ATX ADHD-RS CBCL TRF OROS-MPH SDQ ADHD 12 ADHD