骨吸収抑制薬関連顎骨壊死の病態 ... - perio.jp

1 1 : 2016 : 1, a 1, b 1, c 2, d 1, e 2, f 3, g 4, i 5, j 5, k 6, h 1 2 3 4 5 6 a b c d e f g h i j k COI Conflicts of interest MSD MSD

2 EA MSD ; 2 I BP 2003 BP BP-Related Osteonecrosis of the Jaw, BRONJ 10 1 BP / BRONJ BRONJ 10 BRONJ BRONJ 2-4 RANKL Receptor Activator of NF B Ligand IgG2 BP 1 BP 5 ONJ BRONJ ONJ DRONJ.

3 Denosumab-related ONJ 6 BP ONJ ARONJ Anti-resorptive agents-related ONJ 7 BRONJ DRONJ AAOMS MRONJ, Medication-related ONJ 8 ONJ 2 ONJ ARONJ 2012 10 BRONJ 3 DRONJ ARONJ ONJ 6 ARONJ II ARONJ 1 ARONJ 1 3 2

4 3 800 1011 1012 /cm3 4 5 ARONJ 9 2 ARONJ AAOMS 2014 3 ARONJ 1 BP 2 3 8 8 8 0 3 ARONJ ONJ 2 1 BP 10 69 10 0 90 BP ONJ ONJ 10 0 2 ONJ 1 ONJ 5,723 52 37 89 ONJ 6, 10 3 ARONJ BRONJ BRONJ 2006 2008 263 11 2011 2013 4,797 BRONJ 12 2006 2008 4 2011 2013 4 BRONJ BP 11.

5 12 BP BRONJ BP DRONJ 2012 4 17 2015 7 31 120 DRONJ 58 BP 2013 6 11 2015 12 31 20 15 BP DRONJ 4 ARONJ 1 ARONJ BP Vincent ARONJ 1 0 2012 ONJ 0 ONJ 0 ARONJ 25 30 13 0 ONJ 13 ONJ 0 2, 14 AAOMS 0 ONJ 8 AAOMS 0 ONJ 1 ARONJ 0* : / Vincent : 1 : : 2 : : / 3.

6 1 : / : 0 ONJ 13 5 2 BRONJ DRONJ DRONJ 15 BRONJ DRONJ 2 6, 10 DRONJ BRONJ DRONJ BRONJ 3 ARONJBP ARONJ 16 ONJ 2 ARONJ 4 1 1 ARONJ A: 0 62 B: 1 73 C.

7 2 78 D: 3 68 A B C * C D * D 6 CT CT CT CT X CT CT MRI MRI CT CT MRI 17 hybrid SPECT/CT 18.

8 19 18F-FDG PET PET/CT BRONJ DRONJ 5 ARONJ ARONJ BRONJ BP 20 BRONJ 2A 2B / BP 21 2B BRONJ 22 DRONJ 23 BRONJ DRONJ 2 BRONJ BP BRONJ. A.

9 B: : 7 5 ARONJ ARONJ 2 BRONJ BP BRONJ BP 24, 25 DRONJ 2012 ONJ 2 ARONJ 1 : 2 BP BP BP: BP: : : 3 Ca D 4 MMP-2 P450-2C SNP5 6.

10 8 BP ONJ 26 BP ONJ 27 6 ARONJ ARONJ BP ARONJ ARONJ BP RANKL ONJ 28-30 ARONJ ARONJ ARONJ 28 1