アンモニアPET血流イメージングの実際 －検査法・解析・評 …

1 17 -3 PET PET 13N-ammonia PET imaging -Methodology and Quantitative analysis of myocardial blood flow- Mitsuru Momose Kenji Fukushima Chisato KondoKoichiro Abe Shuji Sakai Department of Diagnostic Imaging and Nuclear Medicine Tokyo Women s Medical University PET 13N- PET 2012 4 20 13N- SPECT 10 70 SPECT 4 1 1 time of flight TOF 13N- 370 MBq 30 10 PET 2 3 8 PET CT

2 PET PET CT CT 2 CT 40 3. 1 3 syngo MBF Siemens Munich Heart QPET Cedars-Sinai PMOD PMOD Technologies MFR / Rate Pressure product HR x sBP 1 PET 2 2:56:47 PM18 QGS n=5 age 41 13 ml/g/min MFR QGS EDV 92 17 ESV 28 10mL EF 71.

3 EDV 105 18 ESV 30 10mL EF 72 TID ratio stressEDV/restEDV EDV 2 58 stressEDV 102mL restEDV 78mL TID ratio MFR TID PET TID 5. PET 3 60 HbA1c PET MRA #7 50% #2 50% SPECT PET LAD RCA MFR MFR gatePET TID TID ratio TID MFR 1 2 PET 3 1 Yokoyama I, Yonekura K, Ohtake T, Yang W, Shin WS, Yamada N, et al.

4 Coronary microangiopathy in type 2 diabetic patients: relation to glycemic control, sex, and microvascular angina rather than to coronary artery disease. J Nucl Med 2000;41(6) Alexanderson E, Garcia-Rojas L, Jimenez M, Jacome R, Calleja R, Martinez A, et al. Effect of ezetimibe-simvastatine over endothelial dysfunction in dyslipidemic patients: assessment by 13N-ammonia positron emission tomography. J Nucl Cardiol 2010;17(6) Fiechter M, Ghadri JR, Gebhard C, Fuchs TA, Pazhenkottil AP, Nkoulou RN, et al.

5 Diagnostic value of 13N-ammonia myocardial perfusion PET: added value of myocardial flow reserve. J Nucl Med 2012;53(8):1230-4. 2:56:48 PM