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Pharma Solutions Avicel® Selection Guide

Nutrition & BiosciencesAvicel Selection GuidePharma SolutionsA versatile excipient addressing your critical formulation needs. Functionalities tailored to requirements of dosage form, formulation and technologyAvicel MCC Direct Compression Wet Granulation Co-processed Avicel MCC + SiO2 MCC + DCP MCC + Mannitol MCC + Guar Gum PH-102 SMCC 90 HFE-102 PH-113 PH-112 PH-302 PH-301 PH-200 LM PH-103 PH-102 SCG PH-105 PH-200 NMT Not More Than Bulk Density, Un- tapped Decreasing Moisture Content Nominal Particle Size g/cc g/cc 20 m 150 m 100 m 50 m 200 m Increased stability of moisture sensitive drugs Increased Batch Size NMT 5% NMT 3% NMT 2% NMT Increase Flow SMCC HD-90 PH-101 SMCC 50 DG CE-15 PH-102 SMCC 90 HFE-102 PH-113 PH-112 PH-302 PH-301 PH-200 LM PH-103 PH-102 SCG PH-105 PH-200 NMT Not More Than Bulk Density, Un- tapped Decreasing Moisture Content Nominal Particle Size g/cc g/cc 20 m 150 m 100 m 50 m 200 m Increased stability of moisture sensitive drug

Un-tapped Decreasing Moisture Content Nominal Particle Size 0.3 g/cc 0.4 g/cc 20 µ m 150 µ m 100 µ m 50 µ m 200 µ m Increased stability of moisture sensitive drugs Increased Batch Size NMT 5% NMT 3% NMT 2% NMT 1.5% Increase Flow SMCC HD-90 PH-101 SMCC 50 DG CE-15CE-15 SMCC 90 HFE-102 PH-113 PH-112 PH-103 PH-200 NMT Bulk Density,

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Transcription of Pharma Solutions Avicel® Selection Guide

1 Nutrition & BiosciencesAvicel Selection GuidePharma SolutionsA versatile excipient addressing your critical formulation needs. Functionalities tailored to requirements of dosage form, formulation and technologyAvicel MCC Direct Compression Wet Granulation Co-processed Avicel MCC + SiO2 MCC + DCP MCC + Mannitol MCC + Guar Gum PH-102 SMCC 90 HFE-102 PH-113 PH-112 PH-302 PH-301 PH-200 LM PH-103 PH-102 SCG PH-105 PH-200 NMT Not More Than Bulk Density, Un- tapped Decreasing Moisture Content Nominal Particle Size g/cc g/cc 20 m 150 m 100 m 50 m 200 m Increased stability of moisture sensitive drugs Increased Batch Size NMT 5% NMT 3% NMT 2% NMT Increase Flow SMCC HD-90 PH-101 SMCC 50 DG CE-15 PH-102 SMCC 90 HFE-102 PH-113 PH-112 PH-302 PH-301 PH-200 LM PH-103 PH-102 SCG PH-105 PH-200 NMT Not More Than Bulk Density.

2 Un- tapped Decreasing Moisture Content Nominal Particle Size g/cc g/cc 20 m 150 m 100 m 50 m 200 m Increased stability of moisture sensitive drugs Increased Batch Size NMT 5% NMT 3% NMT 2% NMT Increase Flow SMCC HD-90 PH-101 SMCC 50 DG CE-15 PH-102 SMCC 90 HFE-102 PH-113 PH-112 PH-302 PH-301 PH-200 LM PH-103 PH-102 SCG PH-105 PH-200 NMT Not More Than Bulk Density, Un- tapped Decreasing Moisture Content Nominal Particle Size g/cc g/cc 20 m 150 m 100 m 50 m 200 m Increased stability of moisture sensitive drugs Increased Batch Size NMT 5% NMT 3% NMT 2% NMT Increase Flow SMCC HD-90 PH-101 SMCC 50 DG CE-15 Avicel Product GuideMarket Trends and Needs Use of direct compression, high-speed tabletting machines Implementation of continuous manufacturing Need for safe and reliable drug performance Formulation flexibility immediate, controlled.

3 Delayed release Increasing demand on excipient s functionality Reliable and simplified supply chain set ups Particle engineering and co-processing are attractive tools to meet market needsWith the development of differentiated grades, Avicel remains an indispensable formulation tool, boosting productivity and meeting tough formulation challenges. Contact DuPont for assistance with choosing the optimal Avicel grade or for help with your tableting formulation & HO 00019 - 0 E L


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