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1 2016 1 12 2015 10 PPAR K-877 PROMINENT BWH Center for Cardiovascular Disease Prevention CCVDP CCVDP Academic Research Organization ARO JUPITER CANTOS CCVDP PROMINENT Kowa Research Institute, Inc. III PROMINENT Pemafibrate to Reduce cardiovascular OutcoMes by reducing triglycerides IN diabetic patiENTs 30 600 1 Triglycerides TG HDL- 2 K-877 Food and Drug Administration FDA 2017 K-877 SPPARM K-877 PRESS RELEASE K-877 PPAR Selective Peroxisome

2 Proliferator-Activated Receptor Modulator SPPARM , PPAR TG HDL- 2015 10 19 PPAR Peroxisome Proliferator-Activated Receptor TG SPPARM PPAR Selective Peroxisome Proliferator-Activated Receptor Modulator SPPARM , PPAR PPAR 1) 1) Cardiovascular Diabetology (2013)12:82. 3-4-14 TEL 03-3279-7392 3-6-29