Transcription of 프로포폴 [propofol] - drugfree.or.kr
1 [ propofol ] ( propofol ) , . , , , . ICI(Imperial Chemical Industries) 1977 . (Cremophor EL) . 1986 (soybean oil) ( : diprivan) . 1992 , 50 .. 2011 2 ( ) , . , 2000 , .* 2000~2012 44 ( ). Drug Focus | [ propofol ]12 2012 + Winter Korean Association Against Drug Abuse 13 (2,6-diisopropylphenol).
2 , , , . (thiopental, pentothal) . , . , , , , , .. , , , , , . , , 3 . , . (midazolam) (lorazepam) .. (fentanyl), (remifentanyl) . (well being sense) . : ( ~1mg/kg, ) 6~10mg/L( / ) , 2~4mg/L.
3 4 mg/L , 3mg/L . , .. , . 2,6- (2,6-diisopro pylphenol), . (barbiturate) 14 2012 + Winter (benzodiazepine) GABAA , . GABAA 1) , NMDA 2) . GABA .. , . , , , , - ( E), butylhydroxytoluene, acetylsalicylic acid(aspirin) . / .. ( ) .. ( propofol infusion syndrome, PIS) PIS.
4 (catecholamine) . , , . , . , , , , , . , , . GABA ..1) GABA : 2) NMDA : Drug Focus | [ propofol ]Korean Association Against Drug Abuse 15 , . 1 50~100mg, , 100 , . ( ) 40% (pleasurable)( : 542 )3) 2,700 30.
5 (PDR) (addiction) , , , . , . , , , . 5~10 . ( 100 ) . , .. 18 2 3 . ( , ) ( , , , ) , .. 3) Effects of propofol (Ann Fr Anesthesiology 77, 817-818, 1992)
