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1 QSOFA Sepsis-3 ED Journal Club 2017/04/04 PGY5 Sepsis Sepsis septikos Sepsis 3 2016 1992 Sepsis-1 (systemic inflammaoty response syndrome,SIRS) Crit Care Med 1992;20:864 2003 Sepsis-2 ( 24 ) Crit Care Med 2003;31:1250-6 2016 Sepsis-3 Life-threatening organ dysfunction caused by a dysregulated host response to infection Sepsis1 sepsis2 2016 SOFA 2 ICU qSOFA JAMA 2016.

2 315:801 Sepsis-1 SIRS 2 + 2016 SIRS SIRS SIRS Am J Respir Crit Care Med 2015;192:958 N Engl J Med 2015;372:1629 N Engl J Med 2015;372:1629 Severe sepsis SIRS SIRS 2 N Engl J Med 2015;372:1629-38. Am J Respir Crit Care Med 2015; 192:958-964 47 SIRS SIRS 8 1 Sepsis-2 Sepsis1 sepsis2 cut-off 2016 Sepsis-3 2016 2016 SOFA qSOFA 2016 ICU Sepsis Septic shock 2016 qSOFA SOFA Sepsis-3 life-threatening organ dysfunction due to a dysregulated host response to infection gold standard.

3 315(8):762 18 2010 2012 12 130 148907 ) SOFA score, SIRS criteria, LODS score, qSOFA score Primary Secondary ICU ;315(8):762 ICU SOFA LODS SIRS qSOFA LODS SOFA ICU qSOFA LODS SOFA SIRS LODS qSOFA ICU sepsis SOFA ICU Sepsis ;315(8):762 ED qSOFA qSOFA Sepsis-3 criteria.

4 317:301 International multicenter prospective cohort study 30 ( :27 :1 :1 :1) 2016 5 6 1 ED ER or All included ( ) Follow up or vital sign ( ) ER qSOFA ER GCS +SIRS SOFA score Follow up Primary End point 1. 2. 2 ICU end point Secondary End point ICU 72 ICU 72 ICU mean(SD) median(Q1 Q3 IQR) (%)

5 SOFA Primary end point qSOFA qSOFA ROC AUROC qSOFA SIRS HRs Cox Harrell C coefficient Inclusion criteria primary end point Cohen k Sepsis-3 qSOFA score2 10% SOFA score 2 10% sepsis-3 consensus statement 3% inclusion 80% qSOFA score 2 power set 90% 840 P < NCSS 879 260 SOFA 76% 67 (IQR, 48-81) (43%) qSOFA 2 25% SOFA 2 34% SIRS 2 74% Severe sepsis 20% Cohen k 0,87(95%CI, ) 8% qSOFA<2 vs qSOFA 2 3%(2-5) VS 24%(18-30) Primary end point Cohen k ( ) qSOFA ; SOFA ; SIRS ; Severe sepsis ; SIRS severe sepsis qSOFA Incremental AUROC ( ) AUROC curve ; qSOFA (.)

6 Discussions 879 ED sepsis-3 ( qSOFA) qSOFA AUROC SIRS severe sepsis sepsis 3 task force ICU qSOFA AUROC 2 retrospective study qSOFA ICU qSOFA vs. SIRS SIRS 2 11% 93% 27% 75 SIRS 2 ICU 68-93% SIRS 2 SIRS 2 qSOFA<2 SIRS SIRS qSOFA 72 ICU (7%;4-10%)(9%;7-11%) Sepsis qSOFA SIRS sepsis SOFA 2 ED qSOFA 2 sepsis qSOFA sepsis qSOFA Sepsis-3 tack force ED sepsis Limitation Sepsis-3 primary end point 28 qSOFA ED qSOFA qSOFA sepsis ex.

7 ED SOFA SIRS 2 3 1 severe sepsis DNAR Primary end point 74 score ED Conclusions ED qSOFA SIRS severe sepsis sepsis-3 criteria ED ICU qSOFA ED qSOFA qSOFA ED qSOFA