Quick Reference Table Cosmetic Ingredient Review ...

1 IngredientFinding ConclusionCitation 1,10 DecanediolSFinal Report 06/2018 Available from CIR1,2 ButanediolSIJT 31(Suppl. 2):147 168, 2012 1,2 HexanediolSIJT 31(Suppl. 2):147 168, 2012 1,4 ButanediolIThe Panel also concluded that the available data are insufficient to make a determination that 1,4 is safe under the intended conditions of use in Cosmetic Report 06/2018 Available from CIR1,4 Butanediol/Succinic Acid/Adipic Acid/HDI CopolymerSFinal Report 06/2016 Available from CIR1,5 PentanediolSFinal Report 06/2018 Available from CIR1 Hydroxyethyl 4,5 Diamino Pyrazole SulfateSFinal Report 04/2016 Available from CIR1 NaphtholSJACT 8(4):749 768, 1989;IJT 30(Suppl. 2).

2 73 127, 201110 Hydroxydecanoic AcidSQThe CIR Expert Panel concluded that the following ingredients are safe in the present practices of use and concentration described in the safety assessment when formulated to be non irritating and non sensitizing, which may be based on a Hydroxydecanoic Report 04/2019 Available from CIR10 Hydroxystearic AcidSQThe CIR Expert Panel concluded that the following ingredients are safe in the present practices of use and concentration described in the safety assessment when formulated to be non irritating and non sensitizing, which may be based on a Hydroxystearic Report 04/2019 Available from CIR2,3 ButanediolIThe Panel also concluded that the available data are insufficient to make a determination that.

3 2,3 Butanediol .. is safe under the intended conditions of use in Cosmetic Report 06/2018 Available from CIR2,3 NaphthalenediolZThe CIR Expert Panel concludes that the available data are insufficient to support the safety of 2,3 Naphthalenediol as used in 7(3):353 357, 19882,4 DiaminophenolSQOn the basis of the data included in this report, the CIR Expert Panel concludes that 2,4 Diaminophenol and 2,4 Diaminophenol Dihydrochloride are safe for use in hair dyes at concentrations up to (as the free base). 2009 RE Review The Expert Panel noted that 2,4 Diaminophenol Dihydrochloride is now termed 2,4 Diaminophenol 13(5):330 343, 1994; IJT 30(Suppl. 2):73 127, 2011 2,4 Diaminophenol DihydrochlorideSQOn the basis of the data included in this report, the CIR Expert Panel concludes that 2,4 Diaminophenol and 2,4 Diaminophenol Dihydrochloride are safe for use in hair dyes at concentrations up to (as the free base).

4 2009 RE Review The Expert Panel noted that 2,4 Diaminophenol Dihydrochloride is now termed 2,4 Diaminophenol 13(5):330 343, 1994; IJT 30(Suppl. 2):73 127, 2011 2,4 Diaminophenol HClSQOn the basis of the data included in this report, the CIR Expert Panel concludes that 2,4 Diaminophenol and 2,4 Diaminophenol Dihydrochloride are safe for use in hair dyes at concentrations up to (as the free base). 2009 RE Review The Expert Panel noted that 2,4 Diaminophenol Dihydrochloride is now termed 2,4 Diaminophenol 13(5):330 343, 1994; IJT 30(Suppl. 2):73 127, 2011 2,4 Diaminophenoxyethanol DihydrochlorideSJACT 10(1):113 134, 1991; Final Report 12/2007 Available from CIR2,4 Diaminophenoxyethanol HClSJACT 10(1):113 134, 1991; Final Report 12/2007 Available from CIR2,4 Diaminophenoxyethanol SulfateSFinal Report 12/2007 Available from CIR2 Amino 3 HydroxypyridineSIJT 39(S2):91 97,20202 Amino 3 NitrophenolSIJT 28(Suppl.)

5 3):217 251, 20092 Amino 4 HydroxyethylaminoanisoleSQThe CIR Expert Panel concluded that 2 amino 4 hydroxyethylaminoanisole and 2 amino 4 hydroxyethylaminoanisole sulfate are safe for use in oxidative hair dye formulations. Were the free base (2 amino 4 hydroxyethylaminoanisole) to be used in the future, the expectation is that it would be used at concentrations similar to the sulfate salt. The Expert Panel cautions that these ingredients should not be used in hair dye products in which N nitroso compounds may be 32(Suppl. 1):25 35, 2013 2 Amino 4 Hydroxyethylaminoanisole SulfateSQThe CIR Expert Panel concluded that 2 amino 4 hydroxyethylaminoanisole and 2 amino 4 hydroxyethylaminoanisole sulfate are safe for use in oxidative hair dye formulations.

6 Were the free base (2 amino 4 hydroxyethylaminoanisole) to be used in the future, the expectation is that it would be used at concentrations similar to the sulfate salt. The Expert Panel cautions that these ingredients should not be used in hair dye products in which N nitroso compounds may be 32(Suppl. 1):25 35, 2013 2 Amino 4 NitrophenolSIJT 28(Suppl. 3):217 251, 20092 Amino 4 Nitrophenol SulfateSIJT 28(Suppl. 3):217 251, 20092 Amino 5 NitrophenolSIJT 28(Suppl. 3):217 251, 20092 Amino 6 Chloro 4 NitrophenolSQOn the basis of the animal and clinical data included in this report, the CIR Expert Panel concludes that 2 Amino 6 Chloro 4 Nitrophenol and its hydrochloride salt are safe for use in hair dye formulations at concentrations of up to The CIR Expert Panel re affirmed the above conclusion on December 16(S1):131 143, 1997.

7 IJT 36(Suppl 2):14 58, 2017 2 Amino 6 Chloro 4 Nitrophenol HydrochlorideSQOn the basis of the animal and clinical data included in this report, the CIR Expert Panel concludes that 2 Amino 6 Chloro 4 Nitrophenol and its hydrochloride salt are safe for use in hair dye formulations at concentrations of up to IJT 16(S1):131 143, 19972 Bromo 2 Nitropropane 1,3 DiolSQThe evidence at hand indicates 2 Bromo 2 Nitropropane 1,3 Diol to be safe as a Cosmetic Ingredient at concentrations up to and including percent except under circumstances where its action with amines or amides can result in the formation of nitrosamines or 4(4):47 61, 1980; JACT 3(3):139 155, 1984; IJT 25(Suppl.)

8 2) :1 89,2006 2 Chloro p PhenylenediamineSJACT 11(4):521 530, 1992; IJT 30(Suppl. 2):73 127, 2011 2 Chloro p Phenylenediamine SulfateSJACT 11(4):521 530, 1992; IJT 30(Suppl. 2):73 127, 2011 Quick Reference Table Cosmetic Ingredient Review - September 2020 IngredientFinding ConclusionCitation 2 Ethoxy Ethoxy Ethyl MethacrylateSQBased on available data, the CIR Expert Panel concluded that 2 Ethoxy Ethoxy Ethyl is safe as used in nail enhancement products when skin contact is avoided. Products containing these ingredients should be accompanied with directions to avoid skin contact, because of the sensitizing potential of 24(Suppl 5):53 100, 20052 Methyl 5 HydroxyethylaminophenolSJACT 9(2):185 202, 1990; IJT 27(Suppl.

9 1):77 142, 2008 2 MethylresorcinolSJACT 5(3):167 203, 1986; IJT 27(Suppl. 1):77 142, 2008 2 Nitro p PhenylenediamineSJACT 4(3):161 202, 1985; IJT 25(Suppl. 2) :1 89,2006 2 Oleamido 1,3 OctadecanediolSIJT 39(S3):5 25,20203 Methylamino 4 NitrophenoxyethanolSIJT 27(Suppl. 2):41 51, 20083 Nitro p HydroxyethylaminophenolSIJT 28(Suppl. 3):217 251, 20094 Amino 2 HydroxytolueneSJACT 8(4):569 587, 1989; IJT 27(Suppl. 1):77 142, 2008 4 Amino 2 NitrophenolZBased on the data contained in this report, the CIR Expert Panel concludes that 2 amino 3 nitrophenol, 2 amino 4 nitrophenol,2 amino 4 nitrophenol sulfate, 2 amino 5 nitrophenol, 4 amino 3 nitrophenol, 3 nitro p hydroxyethylaminophenol, and 4 hydroxypropylamino 3 nitrophenol are safe as hair dye ingredients in the practices of use and concentration as described in this safety assessment, but the data are insufficient to make a determination of safety for 4 amino 2 28(Suppl.

10 3):217 251, 20094 Amino 3 NitrophenolSIJT 28(Suppl. 3):217 251, 20094 Amino m CresolSIJT 23 (Suppl. 2):1 22, 20044 Chloro 2 AminophenolSQ;ZThe CIR Expert Panel concludes that the available data support the safety of 6 Amino m Cresol, 4 Amino m Cresol, 5 Amino 4 Chloro o Cresol and 5 Amino 6 Chloro o Cresol as used in oxidative and nonoxidative (semipermanent) for dyes. The available data also support the safety of 6 Amino o Cresol and 4 Chloro 2 Aminophenol for use in oxidative hair dyes, but are insufficient to support the safety of 6 Amino o Cresol and 4 Chloro 2 Aminophenol and nonoxidative (semipermanent) hair 23 (Suppl. 2):1 22, 20044 ChlororesorcinolSJACT 15(4):284 294, 1996; IJT 36(Suppl 2):14 58, 2017 4 Hydroxybenzoic AcidSQThe CIR Expert Panel concluded that the following 20 parabens are safe in cosmetics in the present practices of use andconcentration described in the safety assessment when the sum of the combined concentration of parabens in any givenformulation does not exceed %.