Research Article ISSN : 0975-7384 CODEN(USA) : …

1 Available online Journal of Chemical and Pharmaceutical Research , 2015, 7(2):772-780 Research Article issn : 0975 - 7384 coden (USA) : JCPRC5 772 Development and evaluation of novel Fluticasone Propionate Emulgel for topical drug delivery Rajesh Asija*, Nitin Nama, Deepak Sharma Maharishi Arvind Institute of Pharmacy, Jaipur, Rajasthan, India _____ ABSTRACT The studies were conducted with an object to develop even, harmless and efficient delivery system for Fluticasone Propionate. Topical drug delivery has gained a marvellous interest in today s pharmaceutical formulation and Research is going on in achieving better product.

2 Fluticasone Propionate is corticosteroids with anti-inflammatory medication that is generally used to treat eczema and dermatitis. Emulgel is a semi solid preparation which decreases the systemic side effects and to create a more pronounced effect with lower doses of the drug. Emulsion in gel have emerged as one of the most interesting topical drug delivery system as it has twofold release control system. Also the stability of emulsion is increased when it is incorporated into gel. The Emulgel was developed using polymers like Carbopol 934 and HPMC K-100 in various ratios of gel and emulsion.

3 DSC and IR spectral studies were performed to confirm the compatibility of drug and polymers in the formulations. The prepared Emulgel was evaluated for their physical appearance, pH evaluation, spreadability, rheological study, and drug content and in-vitro permeation studies. All formulation was evaluated for their release patterns. The result indicates that Emulgels offers better release, controlled release, or a stable atmosphere for the incorporated drug (Fluticasone Propionate). From studies we can conclude that topical application would be effective by applying through novel delivery system like Emulgel of Fluticasone Propionate.

4 Keywords: Topical delivery, Achieving, Twofold release, Incorporated. _____ INTRODUCTION In the past, the most commonly applied systems were topically applied lotions, creams & ointments for dermatological disorders. The occurrence of systemic side-effects with some of these formulations is indicative of absorption of the drugs through the skin, which lead to the idea of TDDS [1]. Most of the topical preparations are used for the localized effects at the site of their application by virtue of drug penetration into the underlying layers of skin or mucous membranes [2].

5 TDDS, the delivery of drugs across the skin is gaining wide acceptance among patients. On the other hand, topical delivery system increases the contact time and mean resident time of drug at the applied site leading to an increase in local drug concentration. While the pharmacological action of emulgel formulations may not change as rapidly as the solution form [3]. The main advantage of topical delivery system is to bypass first pass metabolism [4]. Avoidance of risk and inconveniences of intravenous therapy and of the varied condition of absorption like pH changes, presence of enzymes, gastric emptying time are other advantages of topical preparations [5, 6].

6 The topical drug delivery system is generally used where the other system of the drug administration fails. Fluticasone Propionate, an effective topical corticosteroid has been used as an anti-inflammatory, antipruritic and corticosteroid agent. Rajesh Asija et al J. Chem. Pharm. Res., 2015, 7(2):772-780 _____ 773 The aim of this work was to develop an emulgel formulation of Fluticasone Propionate , a hydrophobic drug, using Carbopol 934, HPMC as gelling agent & penetration enhancer mentha oil.

7 The influence of gelling agent and penetration enhancers was investigated. Emulgel: An emulgel is a gellified emulsion prepared by mixing an emulsion either water-in-oil (W/O) type or oil-in-water (O/W) type with a gelling agent. Due to solubility problems, most of lipophilic drugs cannot be formulated directly as hydrogel. For this reason; emulgel provide better stability and release of the lipophilic drug in comparison with simple hydrogel base. When gels and emulsions are used in combined form the dosage forms are referred as EMULGELS.

8 In recent years, there has been great attention in the use of novel polymers with complex functions as emulsifiers and thickeners because the gelling capacity of these compounds allows the formulation of stable emulsions and creams by decreasing surface and interfacial tension and at the same time increasing the viscosity of the aqueous phase[7,8,9,10]. EXPERIMENTAL SECTION Materials Fluticasone Propionate was procured from Tirupati Life sciences Pvt. Ltd., Himachal Pradesh. Carbopol 934 and HPMC K100M were procured from Maharishi Arvind Institute of Pharmacy, mansarovar, Jaipur.

9 All other chemicals were used of analytical grade and without any further chemical modification. Preparation of emulgel Preparation of emulsion phases: The oily phase of emulsion was prepared by dissolving span-80 in light liquid paraffin with required quantity of Fluticasone Propionate in ethanol. Mentha oil was added to it as a permeation enhancer. Aqueous phase was prepared by dissolving tween-80 in purified water. Methyl paraben was dissolved in propylene glycol and mixed with aqueous phase.

10 Preparation of gel: Accurately weighed quantity of carbopol-934 and HPMC K100M was taken in a previously dried beaker and 10 ml of distilled water was added to it. It was mixed well using mechanical shaker with constant stirring. More distilled water was added to it to maintain the consistency of the gel. The pH of the formulation was adjusted to to using triethanolamine. Formulation of emulgel: Both the oily and aqueous phases were separately heated to 700C to 800C, than mixed with the continuous stirring and allowed to cool to room temperature.