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Revised April 20, 2017 - arci.com

ARCI Controlled Therapeutic Medication Schedule for Horses - Version Revised April 20, 2017. Controlled Therapeutic Withdrawal Medication Threshold Dosing Specifications Reference Notes Note Guideline 10 nanograms per milliliter as 2-(1- 48 hours Single intravenous dose of Acepromazine University of California Applicable analyte is hydroxyethyl) promazine acepromazine at at Davis project metabolite HEPS. sulfoxide (HEPS) in milligrams per kilogram urine 720 micrograms total dose European Horseracing 1 nanogram per milliliter Albuterol 72 hours intra-nasal only1. Based upon Scientific Liaison See Endnote of urine dosing up to 4 times per day Committee Data Intra-articular administration of 9 milligrams of Betamethasone Intra-articular dosing 10 picograms per Sodium Phosphate and only - applicable milliliter of plasma or 7 days Betamethasone Acetate RMTC study analyte is Betamethasone serum Injectable Suspension, USP betamethasone in (American Regent product plasma or serum #0517-0720-01)2.

3 ARCI Controlled Therapeutic Medications Schedule Ver. 4.0, April 2017 Controlled Therapeutic Medication Threshold Withdrawal Guideline Dosing Specifications Reference Notes Note

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Transcription of Revised April 20, 2017 - arci.com

1 ARCI Controlled Therapeutic Medication Schedule for Horses - Version Revised April 20, 2017. Controlled Therapeutic Withdrawal Medication Threshold Dosing Specifications Reference Notes Note Guideline 10 nanograms per milliliter as 2-(1- 48 hours Single intravenous dose of Acepromazine University of California Applicable analyte is hydroxyethyl) promazine acepromazine at at Davis project metabolite HEPS. sulfoxide (HEPS) in milligrams per kilogram urine 720 micrograms total dose European Horseracing 1 nanogram per milliliter Albuterol 72 hours intra-nasal only1. Based upon Scientific Liaison See Endnote of urine dosing up to 4 times per day Committee Data Intra-articular administration of 9 milligrams of Betamethasone Intra-articular dosing 10 picograms per Sodium Phosphate and only - applicable milliliter of plasma or 7 days Betamethasone Acetate RMTC study analyte is Betamethasone serum Injectable Suspension, USP betamethasone in (American Regent product plasma or serum #0517-0720-01)2.

2 Applicable analytes 300 nanograms per are total butorphanol milliliter of total Journal of Veterinary Single intravenous dose of (drug and conjugates). butorphanol in urine or 2 Pharmacology and butorphanol as Torbugesic in urine and Butorphanol nanograms of free 48 hours Therapeutics doi: (butorphanol tartrate) at butorphanol in butorphanol per milligrams per kilogram plasma (the drug milliliter per milliliter of itself, not any plasma or serum conjugate). 1. Administration of albuterol by any means other than intra-nasally has a high likelihood in resulting in a positive finding. This specifically includes oral administration. Trainers and veterinarians are cautioned against using oral albuterol.

3 2. Intramuscular administration of betamethasone acetate will result in plasma or serum concentrations that will exceed the Regulatory Threshold for weeks or even months, making the horse ineligible to race for an extended period. ARCI Controlled Therapeutic Medications Schedule Ver. , April 2017. 2. Controlled Therapeutic Withdrawal Medication Threshold Dosing Specifications Reference Notes Note Guideline Do not administer Kentucky Equine Drug ivermectin within 48. 6 nanograms per Research milligrams per kilogram hours of a race if the Cetirizine milliliter of plasma or 48 hours Council/University of twice daily for 5 doses horse has been serum California at Davis administered study cetirizine.

4 Kentucky Equine Drug 400 nanograms per Research 20 milligrams per kilogram Cimetidine milliliter of plasma or 24 hours Council/University of twice daily for 7 doses serum California at Davis study Oral administration of 140 picograms per University of California clenbuterol as Ventipulmin . milliliter of urine 4 at Davis; Applicable analyte is Clenbuterol 14 days syrup (Boehringer-Ingelheim or Level of Detection in Boehringer-Ingelheim clenbuterol Vetmedica Inc., NADA 140- plasma or serum3 Vetmedica, Inc. 973) at mcg/kg twice a day 100 picograms per Oral administration of 500. Journal of Veterinary milliliter of milligrams of dantrolene as Pharmacology and Dantrolene 5-hydroxydantrolene in paste (compounding pharmacy).

5 Therapeutics 34, 238 . plasma or serum 48 hours or capsule formulation (Proctor 246. and Gamble). 2 nanograms per milliliter of Dormosedan used carboxydetomidine in KY EDRC, UC in study. Detomidine 48 hours 5 mg IV (once). urine or 1 nanogram per Davis/UF Study. milliter of detomidine in blood. 3. For Quarter Horses: Level of Detection in any permitted biological sample. 4. Clenbuterol is a prohibited substance in Quarter Horses and other breeds racing with Quarter Horses; there is no applicable withdrawal guideline for such horses. ARCI Controlled Therapeutic Medications Schedule Ver. , April 2017. 3. Controlled Therapeutic Withdrawal Medication Threshold Dosing Specifications Reference Notes Note Guideline Intramuscular and intravenous administration of dexamethasone sodium Applicable analyte is 5 picograms per milliliter phosphate or oral Dexamethasone 72 hours RMTC study dexamethasone in of plasma or serum administration of plasma or serum dexamethasone at per kilogram regardless of route Five inch ribbon topical application of 1% diclofenac 5 nanograms per Veterinary Applicable analyte is 48 hours liposomal cream formulation.

6 Diclofenac milliliter of plasma or Therapeutics 6: 57-66 diclofenac in plasma or (Surpass Topical Anti- serum (2005) serum Inflammatory Cream, IDEXX. Pharmaceuticals). 10 micrograms per Applicable analyte is Dimethyl sulfoxide 48 hours Intravenous milliliter of plasma or ARCI model rule DMSO in plasma or (DMSO). serum serum Oral administration of firocoxib 20 nanograms per Applicable analyte is 14 days as EQUIOXX oral paste at a RMTC study Firocoxib milliliter of plasma or firocoxib in plasma or daily dose of milligram per serum serum kilogram for four days ARCI Controlled Therapeutic Medications Schedule Ver. , April 2017. 4. Controlled Therapeutic Withdrawal Medication Threshold Dosing Specifications Reference Notes Note Guideline 100 nanogram per Must also have urine Single Intravenous dose of Furosemide milliliter of plasma or 4 hours furosemide up to 500 ARCI model rule specific gravity <.

7 Serum milligram5 for a violation. RMTC study; Journal Single intravenous dose of 1. of Veterinary 3 picograms per milliliter milligram of glycopyrrolate as Applicable analyte is Glycopyrrolate 48 hours Pharmacology and plasma or serum Glycopyrrolate Injection, USP glycopyrrolate in Therapeutics doi: (American Regent product # plasma or serum 0517-4601-25). Kentucky Equine Drug 12 nanograms per Research Guaifenesin milliliter of plasma or 48 hours 2 grams twice daily for 5 doses Council/University of serum California at Davis study 100 picograms per 10 milligrams total dose Isoflupredone milliliter of plasma or 7 days subcutaneous or 20 milligrams RMTC Study serum total dose in one articular space European Horseracing Applies to total major 20 picograms per 200 milligrams of lidocaine as Scientific Liaison hydroxylated Lidocaine milliliter of total 30H- its hydrochloride salt 72 hours Committee data; Iowa metabolite ( , lidocaine in plasma or administered subcutaneously State University study.)

8 Includes conjugates). serum 5. ARCI-0110929(F)(2)(d) and ARCI-025-020(F)(2)(d) state that the dose of Furosemide shall not exceed 500 milligrams nor be less than 150 milligrams.. ARCI Controlled Therapeutic Medications Schedule Ver. , April 2017. 5. Controlled Therapeutic Withdrawal Medication Threshold Dosing Specifications Reference Notes Note Guideline 10 nanograms total hydroxymepivacaine per Single milligrams per European Horseracing Mepivacaine milliliter of urine or 72 hours kilogram subcutaneous dose of Scientific Liaison above Level of Detection mepivacaine Committee data of mepivacaine in plasma or serum Single intravenous dose of 15. Journal of Veterinary 1 nanogram per milliliter milligrams per kilogram Applicable analyte is Methocarbamol 48 hours Pharmacology and of plasma or serum methocarbamol as Robaxin or methocarbamol in Therapeutics doi: 5 grams orally plasma or serum Total dose of Journal of Veterinary methylprednisolone acetate Pharmacology and suspension in one articular Applicable analyte is 100 picograms per Therapeutics Methylprednisolone See Dosing space6.

9 The recommended methylprednisolone milliliter of plasma or volume 37, Issue 2, Specifications withdrawal for serum pages 125 132, April methylprednisolone acetate is a 2014. minimum of 21 days at a 100. milligram dose Kentucky Equine Drug omeprazole sulfide - Research GastroGuard used in 10 nanograms per Omeprazole 24 hours Orally ( grams) once daily Council/University of the study milliliter of plasma or for 4 doses California at Davis serum study 6. Intramuscular administration of methylprednisolone acetate will result in plasma or serum concentrations that will exceed the Regulatory Threshold for weeks or even months, making the horse ineligible to race for an extended period. Please see Dosing Specifications for recommended withdrawal time.

10 ARCI Controlled Therapeutic Medications Schedule Ver. , April 2017. 6. Controlled Therapeutic Withdrawal Medication Threshold Dosing Specifications Reference Notes Note Guideline Applicable analyte is Prednisolone 1 nanogram per milliliter 48 hours prednisolone in plasma 1 milligram per kilogram orally of plasma or serum or serum Mandatory Procaine penicillin 25 nanograms per RMTC reference surveillance of horse (administration must be Following Intramuscular milliliter of plasma or notes online at owner's expense 6. reported to Commission) entry to race serum hours before racing Kentucky Equine Drug 40 nanograms per 8 milligrams per kilogram Research Ranitidine milliliter of plasma or 24 hours twice daily for 7 doses Council/University of serum California at Davis study 100 picograms per Equine Veterinary Applicable analyte is milliliter of plasma or Total dose of 9 milligram in Journal, triamcinolone acetonide Triamcinolone acetonide serum 7 days one articular space 7 in plasma or serum (2013).


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