Rotterdam

1 In combination RBT Guido Pijper RBT Ossip van Duivenbode RBT Hester Blankestijn RBT Iris van den Broek RBT Hester Blankestijn RBT Iris van den Broek RBT Iris van den Broek RBT Ossip van Duivenbode RBT Iris van den Broek13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical TechnologyRotterdam The Netherlands, 28 - 31 March 2022second announcementIt is our great pleasure to announce that the 13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology will be held in Rotterdam , The Netherlands, in 2022 (provided the pandemic situation and the related regulations will allow this).

2 The conference will be the continuation of the very successful series of scientific meetings, which have been held in Budapest, Paris, Berlin, Florence, Geneva, Barcelona, Malta, Istanbul, Lisbon, Glasgow, Granada and (due to the COVID crisis) in 2021 in a virtual conference series is continuously gaining in impact among the pharmaceutical scientists: With close to 1000 submitted abstracts and more than 1300 participants it has become a well-established major meeting, attracting scientists from all over the world. The World Meetings are organized every two years, usually in March or April in the even , the entire spectrum of topics in the fields of Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology will be covered.

3 This includes for example engineering aspects of manufacturing processes, the portfolio of commercially available excipients enabling formulation of a large variety of drug products and medical devices, the underlying basic sciences ( , physico-chemical principles), cutting-edge characterization techniques of dosage forms in vitro and in vivo, as well as potential pitfalls and hurdles to be overcome during product development, manufacturing and quality conference will be held on 3 and a half days: From Monday (noon) until Thursday (evening). From Tuesday to Thursday, 4 parallel sessions with oral presentations will be held.

4 2 Sessions on industry-related topics, presented by distinguished invited speakers, giving overviews on the current state of the art in the respective fields,2 Sessions with short talks selected from submitted abstracts, presenting most recent research findings in a large variety of the conference, the accompanying exhibition ResearchPharm provides a highly interdisciplinary platform for pharmaceutical scientists working in all fields of drug development & manufacturing in industry, academia and regulatory bodies. This exhibition is steadily growing and offers the possibility to present and learn about the newest trends and products in the areas of pharmaceutical ingredients, developing and processing equipment, analytical technologies, drug products, medical devices and contract , young and experienced scientists from academia and industry will present their latest research achievements in the form of posters, allowing for fruitful and direct discussions with the authors.

5 Please note that these will be real poster presentations, enabling efficient and convenient exchanges between the presenters and interested participants. The organizers of the conference intentionally do not opt for electronic poster presentations on small screens with limited visibility and possibility for aim of the meeting is to bring people together, working in fundamental and applied academic research, the chemical and pharmaceutical industry as well as in the regulatory field. The conditions for the initiation of interesting new collaborations will be provided. We are convinced that these personal interactions are crucially all these reasons, we cordially invite you to join our 13th World Meeting and would be very glad to welcome you in Rotterdam !

6 Paolo Caliceti Juergen Siepmann Joerg Breitkreutz President ADRITELF President APGI President APV13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical TechnologyRotterdam, The Netherlands, 28 - 31 March 2022 Scientific programmeMonday, 28 March 2022 Monday 28 March 2022 Key note lecture Opening Ceremony Coffee break Hot topic lectures Welcome Reception 13:00 13:45 13:45 14:45 14:45 15:30 15:30 17:30 17:30 19:00 Exhibition Key note lecture13:45 - 14:45 From drug delivery to drug discovery Going backward on 25 years of pharmaceutical researchJean-Christophe Leroux, ETH Zurich, Switzerland14:45 - 15:30 Coffee break/exhibitionHot topic session15:30 - 16:10 Small RNA delivery at clinical stageRoel Schaapveld, CEO at InteRNA, Nijmegen, The Netherlands16:10 -16.

7 50 Formulation approaches of RNA drugAndreas Zimmer, University of Graz, Austria16:50 -17:30 Digital health and 3D printing of medicinesAbdul Basit, University College London, London, United Kingdom17:30 - 19:00 Welcome receptionTuesday, 29 March 2022 Tuesday 29 May 2021 Hofburg Posters Exhibition 09:00 11:00 11:00 11:30 11:30 12:00 12:00 13:00 13:00 15:00 15:00 17:00 Invited talks Short talks Invited talks Short talks Plenary lecture Award session Coffee break Lunch break Invited talks: Adjuvants and excipients for vaccine formulations09:00 - 09:40 Designing and building the next generation of vaccine adjuvantsDerek O Hagan, GlaxoSmithKline, United States09:40 -10:20 Formulation aspects: polymersFrancesca Mastrotto, University of Padova, Italy10:20 -11:00 COVID vsaccines: strategies for accerleration of drug product developmentCarmen Arigita, Janssen Pharmaceuticals, Leiden, The NetherlandsInvited talks: Engineering and robotics09:00 - 09:40 Digitalisation of pharmaceutical processes Rok Sibanc, Bayer, Wupptertal, Germany09:40 -10.

8 20 Lab automation and roboticsPatrick Courtney, leader EU Working Group on Analytical Laboratory Robotics, Switzerland10:20 -11:00 Quality assurance in vaccine manufacturingChristoph Peter, BioNTech, Mainz, GermanyShort talks: Oral delivery09:00 - 09:20 Poly(2-alkyl-2-oxazoline) as a polymer platform for highly drug-loaded sustained release tabletsAseel Samaro, University of Ghent, Belgium09:20 - 09:40 Feasibility of nanocellulose/ pectin/ alginate composite hydrogels crosslinked with Ca2+ and citric acid as a superabsorbent materialPichapar O-chongpian, University of Chiang Mai, Thailand09:40 -10:00 Regional bile salt and lipid concentrations in the rat small intestine: a comparison between the lumen and the mucus layerMette Klitgaard, University of Copenhagen, Denmark10:00 - 10:20In-vitro reproduction of the small intestine considering essential intestinal componentsScarlett Zeiringer, University of Graz, Austria10:20 - 10.

9 40 Processing of lipid nanodispersions into solid formulations by spray dryingDenise Steiner, University of Braunschweig, Germany10:40 - 11:00 Tableted freeze-dried sirna -lipoplexes Evaluation of the stability in gastro-intestinal environmentAsad Ur Rehman, University of Paris, FranceShort talks: Dermal and transdermal delivery09:00 - 09:20 Microparticles loaded dissolving microneedle patches for localised and sustained intradermal delivery of amphotericin BKe Peng, Queen s University Belfast, United Kingdom09:20 - 09:403D-printed human hair follicle model to investigate topically administered nano-antibioticsSamy Aliyazdi, University of Saarbr cken, Germany09:40 -10:00 Novel bilayer microarray patch (MAP) assisted long acting intradermal delivery for HIV pre-exposure prophylaxisLalitkumar K.

10 Vora, Queen s University Belfast, United Kingdom10:00 - 10:20 Confocal Raman microscopy for the investigation of drug delivery into biofilms depending on maturation and bacterial compositionPia Kaiser, Goethe University, Frankfurt, Germany10:20 - 10:40 Transdermal delivery of cyclodextrin complexed olanzapine via hydrogel forming microneedle arraysPeter E. McKenna, Queen s University Belfast, United Kingdom10:40 - 11:00 Skin microbiota: set up of a protocol to evaluate a correlation between the microbial flora and skin parametersPaola Perugini, University of Pavia, Italy11:00 - 11:30 Coffee break/exhibition/posters11:30 - 12:00 APV award sessionPlenary lecture12:00 - 13:00 Accelerated and cost-effective biosimilar introduction with an innovative manufacturing process and lean non-clinical and clinical developmentJaap Wieling, Biosana Pharma, Leiden, The Netherlands13:00 - 15:00 Lunch break/exhibition/postersInvited talks.