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1 In-vitro DIC von Willebrand K 1 1 2 CLSI ( ) Na2 1 9 1 3 6 HCT55% 3000rpm 15 1 III IV 4 CO2 ph !

2 ! -70 C 6 ,-20 C 2 37 C 2 4 C 2 1 Ca2+XIIXIIaXIXIaIXIXaPLVIIIaCa2+XXaPLVaC a2+II IIa Ca2+III(TF)VIIaVIICa2+XIIIXIIIaI TF APTT PTVIIIXIXIIIXXVIIIVIIXVIIII Ca2+XIIXIIaXIXIaIXIXaPLVIIIaCa2+XXaPLVaC a2+II IIa Ca2+III(TF)VIIaVIICa2+XIIIXIIIaI tPA,uPA FDP FDP D D 2 E 1 D 2 D- DD FDP PT %70 %70 130 Fib PT 12 APTT 33 PT >120PT % < APTT % mg/dL281219 32 PT >120PT % < APTT % mg/dL281219DD g/mLFDP g/mL >120< >200< PT % >200 APTT % <

3 ICU APTT PT % % mg/dL19124 WBC7800 RBC 8/228/239/12PT % ICD ViK 9/129 K K K II VII IX X 36 48 48 72 PT INR APTT K 5 5 AT AT Xa IXa XIa APTT ACT AT HIT APTT APTT.

4 Vol. 32, No 5 (2009) 9/159/169/16PT % % mg/dL17890117 FDP PT APTT FDP DD DIC DIC PT APTT Fib FDP DD AT 10/3111/1PT % % mg/dL534671DD 11 APTT DIC Fib PLT DD FDP CBC PLT / ATIII TAT SFMC A2PI PIC PIVKA-II K (II,VII,IX,X,PS,PC) 0 10 2 8 5 5 8 2 10 0 DIC 050100150200250100755025 0 (sec) 2 ATIII(%).

5 Vi K Vi K APTT)10203040506070801007550250PT(sec) 2 PT) F-2(%)44F-5(%) (%) (%)> (%) (%) 6 WBC / L10700 RBC / / % % % % >120 PT %< INR---APTT >200 APTT %< mg/dL---FDP g/mL---DD g/mL--- >120 PT %< INR---APTT >200 APTT %< mg/dL---FDP g/mL---DD g/mL---WBC / L10700 RBC / / % % % % Fib FDP DD PT-INR APTT 50 Fib 100 mg/dL FDP 40 g/mL

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