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Section 6. NEW NON-DIALYTIC TREATMENTS FOR …

Section 6. NEW NON-DIALYTIC TREATMENTS FOR acute . kidney injury . Authors: Vincent D'Intini, Martin Gallagher guidelines . No recommendations or suggestions possible due to lack of evidence. kdigo No guidelines created CARI No recommendations possible based on the available evidence No suggestions possible BACKGROUND. Several therapeutic interventions have been investigated with limited promise. The discovery and development of biomarkers for acute kidney injury (AKI) will be beneficial in further evaluating these therapies and help with discovery and development of new options. SEARCH STRATEGY. The search strategy was devised by the authors Databases searched: Medline, Central, Cochrane database of systematic reviews. Date of searches: June 2012. ADEQUACY OF kdigo SEARCH STRATEGY. kdigo clinical Practice Guideline for acute kidney injury did not explore new NON-DIALYTIC TREATMENTS for AKI and hence no search strategy was created. APPLICABILITY OF kdigo RECOMMENDATIONS AND SUGGESTIONS.

KHA-CARI Adaptation of KDIGO Clinical Practice Guideline for Acute Kidney Injury (May 2014) Page 1 Section 6. NEW NON-DIALYTIC TREATMENTS FOR ACUTE

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Transcription of Section 6. NEW NON-DIALYTIC TREATMENTS FOR …

1 Section 6. NEW NON-DIALYTIC TREATMENTS FOR acute . kidney injury . Authors: Vincent D'Intini, Martin Gallagher guidelines . No recommendations or suggestions possible due to lack of evidence. kdigo No guidelines created CARI No recommendations possible based on the available evidence No suggestions possible BACKGROUND. Several therapeutic interventions have been investigated with limited promise. The discovery and development of biomarkers for acute kidney injury (AKI) will be beneficial in further evaluating these therapies and help with discovery and development of new options. SEARCH STRATEGY. The search strategy was devised by the authors Databases searched: Medline, Central, Cochrane database of systematic reviews. Date of searches: June 2012. ADEQUACY OF kdigo SEARCH STRATEGY. kdigo clinical Practice Guideline for acute kidney injury did not explore new NON-DIALYTIC TREATMENTS for AKI and hence no search strategy was created. APPLICABILITY OF kdigo RECOMMENDATIONS AND SUGGESTIONS.

2 kdigo had no recommendations and suggestions on new NON-DIALYTIC TREATMENTS for AKI. in kdigo clinical Practice Guideline for acute kidney injury . WHAT DO OTHER guidelines SAY? kidney Disease Quality Initiative: No recommendations. KHA-CARI Adaptation of kdigo clinical Practice Guideline for acute kidney injury (May 2014) Page 1. UK Renal Association: No recommendations. Canadian Society of Nephrology: No recommendations. European Renal Best Practice guidelines : No recommendations. SUGGESTIONS FOR FUTURE RESEARCH. Currently no theraputic intervention is recommended for acute kidney injury . This field remains a key opportunity for novel agents and research. CONFLICT OF INTEREST. Gallagher received an honorarium from Amgen and Abbvie, Amgen also sponsor a research fellowship at The George Institute. V D'Intini received financial support from Servier to attend the DNT Workshop in Alice Springs in March 2013. KHA-CARI Adaptation of kdigo clinical Practice Guideline for acute kidney injury (May 2014) Page 2.

3 REFERENCES. 1. Di Iorio B, Torraca S, Gustaferro P, et al. High-frequency external muscle stimulation in acute kidney injury (AKI): potential shortening of its clinical course. Clin Nephrol. 2013 Sup; 79(13):37-45. 2. Ko kara A, Kayata M. Renal Cell Apoptosis and New Treatment Options in Sepsis- Induced acute kidney injury . Ren Fail. 2012 Nov 27. 3. De Smedt DM, Elseviers MM, Lins RL et al. injury . Nephrol Dial Transplant. 2012. Nov;27(11):4095-101. 4. Rabb H. The promise of immune cell therapy for acute kidney injury . J Clin Invest. 2012 Nov 1;122(11):3852-3854. 5. Jamadarkhana P, Chaudhary A, Chhipa L, et al. Treatment with a novel hypoxia- inducible factor hydroxylase inhibitor (TRC160334) ameliorates ischemic acute kidney injury . Am J Nephrol. 2012;36(3):208-218. 6. Negi S, Shigematsu T. Current therapeutic strategies for acute kidney injury . Clin Exp Nephrol. 2012 Oct;16(5):672-678. 7. Altun B, Yilmaz R, Aki T, Akoglu Het al. Use of mesenchymal stem cells and darbepoetin improve ischemia-induced acute kidney injury outcomes.

4 Am J Nephrol. 2012;35(6):531-539. 8. Briguori C. Renalguard system in high-risk patients for contrast-induced acute kidney injury . Minerva Cardioangiol. 2012 Jun;60(3):291-297. 9. Oh SW, Chin HJ, Chae DW, Na KY. Erythropoietin improves long-term outcomes in patients with acute kidney injury after coronary artery bypass grafting. J Korean Med Sci. 2012 May;27(5):506-11. 10. Furuichi K, Shintani H, Sakai Y, Ochiya et al. Effects of adipose-derived mesenchymal cells on ischemia-reperfusion injury in kidney . Clin Exp Nephrol. 2012. Oct;16(5):679-689. 11. Pickkers P, Heemskerk S, Schouten J, et al. Alkaline phosphatase for treatment of sepsis-induced acute kidney injury : a prospective randomized double-blind placebo- controlled trial. Crit Care. 2012 Jan 23;16(1):R14. KHA-CARI Adaptation of kdigo clinical Practice Guideline for acute kidney injury (May 2014) Page 3.


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