Segnan N, Patnick J, von Karsa L (eds) (2011) …

1 ! " # $ ! % &' $ ( % " ! " &' $ ! " " )% " * # " " + $ , # , ! " - , # %. " ! " , # / # # ! 0 0+ 1 * , 2 . " ! 4 5+ * & 6 + $ " ! 4 7+ 8 9 : + $ " ! 4 ! < 6 + , # " ! 4 =+ $ " , 9 > + European guidelines for quality assurance in colorectal cancer screening and diagnosis First Edition Editors N. Segnan J. Patnick L. von Karsa II European guidelines for quality assurance in colorectal cancer screening and diagnosis - First edition Financial support of the European Communities through the EU Public health Programme (Develop-ment of European Guidelines for Quality Assurance of Colorectal Cancer Screening (CRC), grant agree-ment No. 2005317), of the Public Affairs Committee of the United European Gastroenterology Federa-tion, and from a cooperative agreement between the American Cancer Society and the Division of Cancer Prevention and Control at the Centers for Disease Control and Prevention is gratefully ac-knowledged.

2 The views expressed in this document are those of the authors and do not necessarily reflect the offi-cial position of the European Commission. Neither the Commission nor any person acting on its behalf can be held responsible for any use that may be made of the information in this document. Special thanks are due to the IARC staff in the Communications, Quality Assurance and Screening Groups who provided technical assistance. Europe Direct is a service to help you find answers to your questions about the European Union. Freephone Number (*): 00 800 6 7 8 9 10 11 (*) Certain mobile telephone operators do not allow access to 00 800 numbers or these calls may be billed. Further information on the EU health Programme is available at: Cataloguing information can be found at the end of this publication. Luxembourg: Publications Office of the European Union, 2010 ISBN 978-92-79-16435-4 (Printed version) ISBN 978-92-79-16574-0 (Electronic version) (Printed version) (Electronic version) European Union, 2010 Printed in Belgium PRINTED ON WHITE CHLORINE-FREE PAPEREEDDIITTOORRSS European guidelines for quality assurance in colorectal cancer screening and diagnosis - First edition III Joan Austoker (1947 2010) This edition is dedicated to the memory of our colleague and friend Joan Austoker who contributed substantially to the development of the European cancer screening guidelines through her pioneering work in communication in cancer screening and prevention.

3 Nereo Segnan Unit of Cancer Epidemiology, Department of Oncology CPO Piemonte (Piedmont Centre for Cancer Prevention) and S. Giovanni University Hospital Turin, Italy Julietta Patnick NHS Cancer Screening Programmes Sheffield, United Kingdom and Oxford University Cancer Screening Research Unit Cancer Epidemiology Unit University of Oxford Oxford, United Kingdom Lawrence von Karsa Quality Assurance Group Section of Early Detection and Prevention International Agency for Research on Cancer Lyon, France IV European guidelines for quality assurance in colorectal cancer screening and diagnosis - First edition Address for correspondence Quality Assurance Group Section of Early Detection and Prevention International Agency for Research on Cancer 150 cours Albert Thomas F-69372 Lyon cedex 08, France AAUUTTHHOORRSS,, CCOONNTTRRIIBBUUTTOORRSS,, EEDDIITTOORRSS AANNDD RREEVVIIEEWWEERRSS European guidelines for quality assurance in colorectal cancer screening and diagnosis - First edition V Authors, Contributors, Editors and ReviewersF1FF Lars Aabakken, Rikshospitalet University Hospital Oslo, Norway Lutz Altenhofen, Central Research Institute of Ambulatory health Care Berlin, Germany Rosemary Ancelle-Park, Direction G n rale de la Sant Paris, France Nata a Antoljak, Croatian National Institute of Public health Zagreb, Croatia Paola Armaroli2, CPO Piemonte Turin, Italy Silvina Arrossi, Centro de Estudios de Estado y Sociedad - CEDES/Consejo Nacional de Investigaciones Cient ficas y T cnicas - CONICET, Buenos Aires Argentina Wendy Atkin, Imperial College London Harrow, United Kingdom Joan Austoker , University of Oxford Oxford, United Kingdom Johannes Blom, Karolinska Institutet Stockholm, Sweden Hermann Brenner.

4 German Cancer Research Centre Heidelberg, Germany Michael Bretthauer , Rikshospitalet University Hospital Oslo, Norway Guido Costamagna, A. Gemelli University Hospital, Rome, Italy Jack Cuzick, Cancer Research UK London, United Kingdom 1 Authors, contributors, editors and reviewers serve in their individual capacities as experts and not as representa-tives of their government or any other organisation with which they are affiliated. Affiliations are provided for identification purposes only. Minor pertinent interests are not listed. These include stock holdings valued at less than US$ 10 000 overall and occasional travel grants totalling less than 5% of time, and consulting on non-regulatory matters totalling less than 2% of time and compensation. Conflicts of interest have been disclosed by the experts between October 2008 and October 2010.

5 No other po-tential conflicts of interest relevant to this publication were reported. 2 The Unit of cancer Epidemiology, Department of Oncology, CPO Piemonte (Piedmont Centre for Cancer Preven-tion) and S. Giovanni University Hospital where N. Segnan , P. Armaroli, R. Banzi, C. Bellisario, L. Giordano, S. Minozzi and C. Senore are based was the co-recipient of a grant in 2006-2009 from the EU for development of guidelines for quality assurance in colorectal cancer screening. AAUUTTHHOORRSS,, CCOONNTTRRIIBBUUTTOORRSS,, EEDDIITTOORRSS AANNDD RREEVVIIEEWWEERRSS VI European guidelines for quality assurance in colorectal cancer screening and diagnosis - First edition Min Dai, National Office for Cancer Prevention & Control Chinese Academy of Medical Sciences, Beijing, China John Daniel3, International Agency for Research on Cancer Lyon, France Marianna De Camargo Cancela3, International Agency for Research on Cancer Lyon, France Evelien Dekker, Academic Medical Centre in Amsterdam Amsterdam, the Netherlands Nadine Delicata, National Breast Screening Centre Valleta, Malta Simon Ducarroz3, International Agency for Research on Cancer Lyon, France Henning Erfkamp, University of Applied Sciences FH Joanneum Graz, Austria Josep Espin s Pi ol, Catalan Cancer Plan L'Hospitalet de Llobregat, Spain Jean Faivre, Digestive Cancer Registry of Burgundy Dijon.

6 France Lynn Faulds-Wood4, European Cancer Patient Coalition Twickenham, United Kingdom Anath Flugelman, National Israeli Cancer Control Centre (NICCC) Haifa, Israel Snje ana Frkovi -Grazio, Department of Pathology, Institute of Oncology Ljubljana, Slovenia Berta Geller, University of Vermont Burlington, Vermont, USA Livia Giordano2, CPO Piemonte Turin, Italy Grazia Grazzini, CSPO Istituto Scientifico Regione Toscana Florence, Italy 3 The International Agency for Research on Cancer (Lyon, France), where L. von Karsa , J. Daniel, M. De Camargo Cancela, S. Ducarroz, C. Herrmann, R. Lambert, T. Lignini, E. Lucas, R. Muwonge, J. Ren, C. Sauvaget, D. Sighoko and L. Voti are based was the co-recipient of a grant in 2006-2009 from the EU for development of guidelines for quality assurance in colorectal cancer screening. 4 The European Cancer Patient Coalition (ECPC), Utrecht, The Netherlands, was the co-recipient of a grant in 2006-2009 from the EU for development of guidelines for quality assurance in colorectal cancer screening.

7 Lynn Faulds Wood was President of the Coalition for the duration of the grant. AAUUTTHHOORRSS,, CCOONNTTRRIIBBUUTTOORRSS,, EEDDIITTOORRSS AANNDD RREEVVIIEEWWEERRSS European guidelines for quality assurance in colorectal cancer screening and diagnosis - First edition VII Jane Green5, University of Oxford Oxford, United Kingdom Stephen Halloran, Royal Surrey County Hospital - NHS Trust Guildford, United Kingdom Chisato Hamashima, National Cancer Centre Tokyo, Japan Christian Herrmann3, International Agency for Research on Cancer Lyon, France Paul Hewitson5, University of Oxford Oxford, United Kingdom Geir Hoff, Norwegian Colorectal Cancer Screening Programme Oslo, Norway Iben Holten, Danish Cancer Society Copenhagen, Denmark Rodrigo Jover, Hospital General Universitario de Alicante Alicante, Spain Michal Kaminski, Centre of Oncology Institute Warsaw, Poland Lawrence von Karsa3, International Agency for Research on Cancer Lyon, France Ernst Kuipers.

8 Erasmus MC Rotterdam, the Netherlands Juozas Kurtinaitis , Lithuanian Cancer Registry Vilnius, Lithuania Ren Lambert3, International Agency for Research on Cancer Lyon, France Iris Lansdorp-Vogelaar, Erasmus MC Rotterdam, the Netherlands Guy Launoy, INSERM Caen, France Won Chul Lee, The Catholic University of Korea College of Medicine Seoul, Korea 5 The University of Oxford, with which J. Patnick is affiliated and where J. Green, P. Hewitson, P. Villain and J. Watson are based was the co-recipient of a grant in 2006-2009 from the EU for development of guidelines for quality assurance in colorectal cancer screening AAUUTTHHOORRSS,, CCOONNTTRRIIBBUUTTOORRSS,, EEDDIITTOORRSS AANNDD RREEVVIIEEWWEERRSS VIII European guidelines for quality assurance in colorectal cancer screening and diagnosis - First edition Roger Leicester, St.

9 George s Hospital London, United Kingdom Marcis Leja, University of Latvia Riga, Latvia David Lieberman, Oregon health & Science University Portland, Oregon, USA Tracy Lignini3, International Agency for Research on Cancer Lyon, France Eric Lucas3, International Agency for Research on Cancer Lyon, France Elsebeth Lynge, University of Copenhagen, Copenhagen, Denmark Szilvia Madai6, MaMMa Healthcare Institute Budapest, Hungary Nea Malila, Finnish Cancer Registry Helsinki, Finland Jos Carlos Marinho, health Administration Central Region Portugal Aveiro, Portugal Giorgio Minoli, Italian Society of Gastroenterology Montorfano, Italy Ant nio Morais, Administracai Regional Sude do Centro Coimbra, Portugal Sue Moss, The Institute of Cancer Research - Royal Cancer Hospital Sutton, United Kingdom Richard Muwonge3, International Agency for Research on Cancer Lyon, France Marion Nadel, Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia, USA Luciana Neamtiu, Institutul Oncologic I.

10 Chiricuta Cluj, Romania Julietta Patnick5, NHS Cancer Screening Programmes Sheffield, United Kingdom 6 The Public Association for Healthy People (PAHP), Budapest, Hungary with which S. Madai is affiliated was the co-recipient of a grant in 2006-2009 from the EU for development of guidelines for quality assurance in colorectal cancer screening. AAUUTTHHOORRSS,, CCOONNTTRRIIBBUUTTOORRSS,, EEDDIITTOORRSS AANNDD RREEVVIIEEWWEERRSS European guidelines for quality assurance in colorectal cancer screening and diagnosis - First edition IX Merc Peris Tuser, Cancer Prevention and Control Unit Catalan Cancer L'Hospitalet de Llobregat, Spain Michael Pignone, University of North Carolina Chapel Hill, North Carolina, USA Christian Pox, Medizinische Klinik Ruh Universit t Bochum, Germany Maja Primic- akelj, Epidemiology and Cancer Registries, Institute of Oncology Ljubljana, Slovenia Joseph Victor Psaila, Ministry of health , the Elderly, and Community Care Valleta, Malta Phil Quirke, Leeds Institute of Molecular Medicine St James University Hospital Leeds, United Kingdom Linda Rabeneck, University of Toronto and Cancer Care Ontario Toronto, Canada David F.