START-UP VALUATION OF BIOTECH COMPANIES WITH …

1 START-UP VALUATION OF BIOTECH COMPANIES with real options A case study of the START-UP Organovo Holdings, Inc. Patrick Legland ( thesis Supervisor) Affiliate Professor in Finance at HEC Paris master thesis HEC Paris Celine G bel June 2016 2016 Celine G bel. All rights reserved. The author hereby grants to HEC Paris permission to reproduce and to distribute publicly paper and electronic copies of this thesis document in whole or in part in any medium now known or hereafter created. 2 START-UP VALUATION of BIOTECH COMPANIES with real options A case study of the START-UP Organovo Holdings, Inc.

2 Written by Celine G bel Abstract: This master thesis examines several valuations methods for young COMPANIES . start -ups are generally characterised by negative earnings, pure equity financing and binary business models. Traditional VALUATION methods, such as the Discounted Cash Flow, VALUATION multiples or comparable transactions, cannot be applied due to start ups high degree of uncertainty, short histories, volatile discount rates and little publicly available data on financials, comparable COMPANIES or comparable transactions. Consequently, new VALUATION methods, the Venture Capital method, the First Chicago method, the Damodaran approach and real Option VALUATION , will be presented and directly applied to the 3D bioprinting START-UP Organovo.

3 The new VALUATION methods take the uncertainty of start -ups into account and allow more flexibility regarding timing and investment decisions. On top of this, the VALUATION of intangible assets is shortly discussed, as it is especially important for start -ups with a strong intellectual property portfolio. This master thesis also highlights non-financials factors in VALUATION , since the personal skills and experience of the founder and management team can have a large impact on the START-UP s value. The author concludes by proposing several areas of further research which will help to improve the current understanding of START-UP VALUATION .

4 Key words: START-UP VALUATION , BIOTECH start -ups, new VALUATION approaches, START-UP value, START-UP discount rate, Damodaran VALUATION , First Chicago Method, Venture Capital Method, real Option VALUATION , 3D bioprinting, Organovo thesis supervisor: Patrick Legland 4 Table of Contents 1. Introduction .. 5 2. START-UP characteristics and development stages .. 6 3. Limitations of traditional VALUATION techniques for start -ups .. 8 a) The discounted cash flow method .. 8 b) The multiples method .. 11 c) The transaction method .. 13 d) The discount rate .. 15 4. Introduction of the case study Organovo Holdings, Inc.

5 17 a) Company overview and strategy .. 18 b) Financial and market analysis .. 20 c) VALUATION approach .. 25 5. Alternative VALUATION methods for start -ups applied to Organovo .. 26 a) The Venture Capital method .. 26 i. Principles of the Venture Capital method .. 26 ii. Limitations of this VALUATION method .. 29 b) The First Chicago method .. 31 i. Principles of the First Chicago method .. 32 ii. Limitations of this VALUATION method .. 35 c) The Damodaran approach .. 36 i. Estimation of future cash flows .. 36 ii. Estimation of the discount rate .. 43 iii. Estimation of the terminal value .. 48 d) The real option approach.

6 50 i. Principles of the real option method .. 51 ii. VALUATION of options .. 55 iii. Limitations of this VALUATION method .. 64 iv. Applicability for START-UP VALUATION .. 65 e) VALUATION of intangibles .. 66 i. Market based VALUATION method .. 67 ii. Cost based VALUATION method .. 68 iii. Income-based VALUATION method .. 68 iv. Challenges of valuing intangible assets .. 69 6. Verification of the VALUATION methods .. 70 a) Alternative approaches to consider .. 72 7. Conclusion and recommended research .. 73 8. Bibliography .. 75 9. Appendix .. 80 5 1. Introduction Everything that can be counted does not necessarily count; everything that counts cannot necessarily be counted.

7 - Albert Einstein Especially due to the skyrocketing valuations of young COMPANIES , such as Uber ($ ), AirBnB ($ ) and Palantir ($ ), many start -ups have been chasing billion-dollar unicorn valuations. Venture capitalist are searching for innovative ideas, excellent management skills and great business models to make their investment the next huge success. start -ups in the areas of financial technology, the Internet of Things and digital health are trending at the moment, as more and more graduates are inspired by the infamous growth stories of start -ups like Facebook, Dropbox and Snapchat.

8 However, veterans, such as Bill Gates, warn to be cautious with unicorn valuations, because young COMPANIES , like payment provider Square and cloud storage company Box, just to name a few examples, have been disappointing investors with high stock market fluctuations. Determining the financial value of the company becomes an inevitable question for founders and investors, when agreeing on giving away a specific percentage of the founders START-UP for a specific amount of investment. Several websites, such as YouNoodle, claim to predict the START-UP value through an algorism, which allocates a certain value after answering a number of questions online.

9 But is START-UP VALUATION that simple? Clearly, assessing the value of an early stage growth company is not easy, mainly due to the short financial history, uncertain growth potential and little comparability to listed COMPANIES or past transactions. Therefore, more and more investors as well as founders are wondering: How can a START-UP actually be valued adequately? The aim of this research paper is to assess which methods are most applicable for START-UP VALUATION and come up with a VALUATION method for BIOTECH COMPANIES through a case study of the American 3D human tissue bioprinting START-UP Organovo.

10 The first part of this thesis will highlight current research, existing literature and several VALUATION techniques. After first introducing general characteristics of start -ups, including life stages and financing, the traditional VALUATION methods will be discussed. Since these methods cannnot be used for start -ups, alternative methods for valuing young COMPANIES will be presented. These new methods will take the shortcomings and main characteristics of start -ups, no history, negative earnings and fully equity finance, into account. Different VALUATION methods, such as the venture capital method, the Damodaran approach and the real options approach, will be discussed and their limitations highlighted at the end of each section.