T4N0M0非小細胞肺癌に対する同時 ... - jrosg.jp

1 jrosg Japanese Radiation Oncology Study Group jrosg 10-1 A I 2 Phase I study of stereotactic body radiation therapy (SBRT) for stage IA, centrally located non-small cell lung cancer I 082-257-1545 Fax 082-257-1546 082-257-1545 Fax 082-257-1546 22 4 12 22 6 8 1 Ve r 1.

2 0 22 7 12 2 Ve r 22 7 24 2 Ve r 2 . 0 22 7 26 2 Ve r 2 . 1 IA I jrosg 10-1 2 0. 1. IA T1N0M0 CR, PR, SD 3 60Gy/8 10 D LT Endpoints PD 2cm P RV D LT 0-3 4 4 2 IA I jrosg 10-1 3 0.

3 2. T1N0M0 maximum tolerated dose; MTD 0. 3. Endpoints Primary endpoint 12 Secondary endpoints 12 3 3 3 0. 4. 35 X CT CT/MRI 56 FDG-PET T1a, T1bN0M0 IA CT/MRI 2cm planning organ at risk volume: PRV 35 PaO2 60torr/mmHg 700ml 20 85 Eastern Cooperative Oncology Group (ECOG) performance status 0-2 informed consent IA I jrosg 10-1 4 0.

4 5. 1 1 52 -68Gy superposition 3-5 8 10 -14 21 0. 6. 10-50 10 3 3 6 0. 7. CRF jrosg IA I jrosg 10-1 5 0. ---------------------------------------- ---------------------------------------- ---- 2 ---------------------------------------- ---------------------------------------- ------------------------ 2 ---------------------------------------- ---------------------------------------- ----------------------------- 3 ---------------------------------------- ---------------------------------------- ----------------- 3 ---------------------------------------- ---------------------------------------- ----------------------------- 3

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