TABLE OF CONTENTS - aacr.org

1 AACR ANNUAL MEETING 2018 PROGRAM GUIDETABLE OF CONTENTS 1 WELCOME LETTER 2-24 COMMITTEES 2 Annual Meeting Program Committee 4 Scientific Program Subcommittee Members 8 Clinical Trials, Education, and Satellite Educational Symposia Committees 9 AACR Officers, Directors, and Foundation 10 Standing Committees 14 Specialty Award Committee 14 Scientific Achievement Awards Committee 17 Scientific Grant Review Committees 21 Scientific Working Group Steering Committees 23 Constituency Groups 24 AACR 50-Year Members and Honorary Members 25-30 SUPPORTERS 25 Annual Meeting 2018 Supporters 28 Research Grants and Fellowships 29 Special Conference Supporters for 2017-2018 30 Sustaining Members 31-45 GENERAL INFORMATION 46-57 MAPS 46 McCormick Place North/South Exhibit Hall Floor Plan 48 McCormick Place North Levels 1 and 2 50 McCormick Place North Levels 3 and 4 52 McCormick Place South Levels 1 and 54 McCormick Place South Levels 3, 4.

2 And 5 56 McCormick Place West 58-84 SATURDAY, APRIL 14 85-116 SUNDAY, APRIL 15 87 Opening Ceremony 88 Opening Plenary Session 88 Pezcoller Foundation-AACR International Award for Extraordinary Achievement in Cancer Research 111 Distinguished Lecture: Phillip A. Sharp 112 AACR-Irving Weinstein Foundation Distinguished Lecture 113 AACR-MICR Jane Cooke Wright Memorial Lectureship 114 Presidential Address 117-158 MONDAY, APRIL 16 119 Distinguished Lecture: Anna D. Barker 119 Distinguished Lecture: C. Ken Osborne 122 Plenary Session 141 NCI Director s Address and Fireside Chat with AACR Leaders 152 AACR-Waun Ki Hong Award for Outstanding Achievement in Translational and Clinical Cancer Research 154 AACR Clowes Memorial Award 154 AACR-WICR Charlotte Friend Memorial Lectureship 157 AACR Princess Takamatsu Memorial Lectureship 159-196 TUESDAY, APRIL 17 163 Plenary Session 172 Gertrude B.

3 Elion Cancer Research Award Lecture 182 Outstanding Achievement in Chemistry in Cancer Research 192 AACR-CRI Lloyd Award in Cancer Immunology 193 AACR-American Cancer Society Award for Research Excellence in Cancer Epidemiology and Prevention 193 AACR Joseph H. Burchenal Memorial Award for Outstanding Achievement in Clinical Cancer Research 197-206 WEDNESDAY, APRIL 18 206 Plenary Session 207-224 TRAVEL AWARDS 207 Scholar-in-Training Awards 219 Faculty Scholar Awards 220 Minority Scholar Awards 222 Women in Cancer Research Scholar Awards 224 AACR-Undergraduate Scholar AwardsPROGRAM GUIDETABLE OF CONTENTSPROGRAM GUIDE 1 WELCOMEWELCOMEDear Colleagues and Friends of the AACR, It is our honor and pleasure to welcome you to Chicago, Illinois for the 109th Annual Meeting of the American Association for Cancer Research (AACR). With over 22,000 laboratory researchers, clinicians, patient advocates, and other oncology professionals from around the world in attendance, the AACR Annual Meeting 2018 will continue the tradition of being the premier cancer research event in the world where the latest and most exciting basic, translational, and clinical discoveries, including cancer prevention studies, are presented and discussed.

4 During this past year, we have seen exciting new basic science findings, new drug approvals, and expanded use of genomic data for precision oncology. Scientists are now harnessing the power of the physical sciences, mathematics, engineering, and artificial intelligence to diagnose cancer at an earlier stage and to understand and track its progression. They are also concentrating their efforts on cancer in minorities and the medically underserved, working to eliminate the persistent disparities in cancer outcomes. These developments are reflected in the program and theme for the Annual Meeting 2018: Driving Innovative Cancer Science to Patient Care. We want to thank the members of the Annual Meeting Program Committee, Education Committee, and Clinical Trials Committee for their outstanding contributions to the development of a multidisciplinary program that highlights emerging scientific areas and reflects the breadth and depth of the rapidly advancing cancer research field.

5 We will feature new sessions on cancer health disparities that have been inspired by an important AACR presidential initiative. Issues related to survivorship will be addressed in several formats, including a special session in the memory of Dr. Jimmie C. Holland. The AACR has forged partnerships with organizations around the world, and the meeting program highlights how important global scientific collaborations are advancing cancer science. We will also hear the first major public address from the new Director of the National Cancer Institute ( ), Dr. Norman E. Sharpless, in which he will outline his vision and goals for the institute. In addition to the state-of-the-art translational science that will be presented throughout the program, a record number of oncology clinical trials, , over 170 completed trials or trials in progress, will be presented in various formats. Exciting trials, including several with practice-changing results, will be highlighted in the Opening Plenary Session and in Clinical Trials Plenary Sessions, which pair each trial with a presentation focusing on the science behind the trial and its implications for delivering improved care to patients.

6 Other trials will be presented in minisymposia and other deeply appreciate the work done by members of the Program Committee who reviewed over 6,000 proffered papers submitted to the Annual Meeting and organized them into poster discussion sessions, regular poster sessions, and minisymposia. We are extremely grateful to the corporations, organizations, and foundations that have provided generous financial support for the AACR Annual Meeting 2018. These valued contributions help make possible this critically important forum for the exchange of scientific and clinical information that will lead to fruitful collaborations and advances in the field. Their commitment also enables the professional advancement of the next generation of leaders in cancer research through their support of a variety of educational sessions, research grants, scholar-in-training awards, and scientific merit awards. Thank you for joining us! We encourage you to participate fully in the many discussions and networking opportunities throughout the meeting.

7 We are confident that you will be inspired and energized by your experience at the Annual Meeting this , Elaine R. Mardis, PhD Michael A. Caligiuri, MD Margaret Foti, PhD, MD (hc) Chair, 2018 Program Committee President, 2017-2018 Chief Executive Officer President-Elect, 2018-20192 AACR ANNUAL MEETING 2018 COMMITTEESANNUAL MEETING PROGRAM COMMITTEEC hairElaine R. Mardis CochairsJulian AdamsJonathan ChernoffChi Van DangAngelo M. DeMarzoMark W. DewhirstRamiro GarzonMaura L. GillisonJoe W. GrayObi Lee GriffithPatrick HwuNada JabadoPasi A. J nneLee W. JonesJos JonkersRick A. KittlesMichael V. KnoppRoss L. LevineX. Shirley LiuDavid MalkinLisa A. NewmanKlaus PantelAnil Vasdev ParwaniEdith A. PerezHelen M. Piwnica-WormsTimothy R. RebbeckJohn C. ReedDavid M. ReeseThomas A. SellersAlice T. ShawYu ShyrShinsuke SuzukiPatrick TanKenneth Kenji TanabeValerie M. WeaverDanny R. WelchJedd D.

8 WolchokPaul WorkmanDouglas YeeMembersGoncalo AbecasisJulio A. Aguirre-GhisoIannis Aifantis Jaffer A. AjaniCatherine Alix-PanabieresMichael AngeloCharlotte E. AriyanMariano Barbacid Brad BehnkeJordan D. BerlinJason N. BermanAndrea H. BildNancy J. BoudreauDonita C. BradyJames B. BrugarolasMargaret CallahanJonathan S. CebonJames R. CerhanHoward Y. ChangHeather R. ChristofkKarlene A. CimprichNorman ColemanToby CornishGeorge CoukosChris M. CounterLisa M. CoussensAdrienne D. CoxChristina CurtisMelissa B. DavisJames A. DeCaprioPrashant DesaiLuis A. DiazMax DiehnFederica Di Nicolantonio Caroline DiveLukas E. DowDaniel DurocherUmamaheswar DuvvuriBarbara Fingleton Rebecca C. FitzgeraldKeith T. FlahertyStefan FrohlingThomas F. GajewskiSusan M. GalbraithCyrus M. GhajarRichard J. GilbertsonCOMMITTEESPROGRAM GUIDE 3 COMMITTEESP eter M. GlazerH. Leighton Grimes Metin GurcanEric B. HauraDaniel F. HayesRoy S. HerbstCelestia S. HiganoTheodore Sunki HongDouglas R.

9 HurstSara A. HurvitzNola M. HyltonTomoo IwakumaKatherine A. JanewayCigall Kadoch Susan M. KaechYibin KangSakari KauppinenLaCreis R. Kidd Tari A. KingJohn M. KirkwoodBeatrice S. KnudsenHenry M. KuererPawan KumarJeffrey L. KutokDavid KwonQuynh-Thu LeJ. Jack LeeChristina Leslie Peter LewisChristopher I. LiHan LiangJason W. LocasaleChristine M. Lovly Guillermina LozanoMathieu LupienJacek MajewskiBrendan D. ManningGuido MarcucciFrank McCormickJane E. MendezJeffrey A. MeyerhardtTodd W. MillerBradley J. MonkClare Montagut Robert F. MurphySenthil K. MuthuswamyNicholas E. NavinErik R. NelsonKim E. NicholsHiroyoshi NishikawaMichele PaganoJulie R. PalmerVito J. PalombellaLiron Pantanowitz Giovanni ParmigianiElectra D. PaskettDana Pe erKah Whye PengDanilo Perrotti Mark R. PhilipsSylvia K. PlevritisStephen R. PlymatePamela S. Ohashi Jennifer K. RicherBrian M. Rivers Caroline RobertBrian RodgersAnil K. RustgiOwen SansomRachel SchiffZachary SchugNikolaus SchultzAlmut SchulzeLawrence H.

10 Schwartz Julie SchwarzWilliam R. SellersPadmandee SharmaPeter SicinskiJared SimpsonMelanie A. SimpsonJonathan P. SleemanJean-Charles SoriaPaul T. SpellmanDavid R. SpigelDouglas R. SpitzMariana Stern Joshua M. StuartMelody A. Swartz Mario SznolSufi M. ThomasJeffrey John TomaszewskiScott A. TomlinsDavid A. TuvesonShelley S. TworogerCOMMITTEES4 AACR ANNUAL MEETING 2018 COMMITTEESE liezer M. van AllenPaul J. van Diest Victor E. VelculescuKristiina VuoriMarkus WarmuthAlana L. WelmCarol L. WilliamsKwok-Kin WongTimothy A. YapClayton C. YatesBruce R. ZetterSCIENTIFIC PROGRAM SUBCOMMITTEE MEMBERSM olecular and Cellular Biology/Genetics Cell Growth Signaling PathwaysDavid M. Virshup, ChairRichard L. EckertStephen R. PlymateAlex TokerCell DeathAnthony G. Letai, ChairChendil DamodaranMariana Y. KonoplevaLin ZhangOncogenes and Tumor Suppressor GenesFrank J. Rauscher III, ChairChris CounterTomoo IwakumaDavid LargaespadaGene Regulation and Transcription FactorsCarol Lange, ChairChristopher C.