TechNical DaTa sheeT - Nisso HPC

1 Nisso hpcsslsllmhsFpmPa s @20 C/2% ~ ~ ~ ~ 4001,000 ~ 4,000 Molecular Weight/GPC method40,000100,000140,000620,000910,000 AvailabilityRegular type 99% passes through 40 mesh (350 m) Fine powder type 99% passes through 100 mesh (150 m) super Fine powder type (D50 < 20 m) ApplicationFilm coatingBindingsustained releaseThickeningsolubilityHPC is soluble in water, water-free lower alcohols and polar solvents. Solutions are transparent and have a smooth feel. Solubility in organic solvents is limited only by the viscosity increase. SolubleWater, Methyl alcohol, Ethyl alcohol, Isopropyl alcohol, Pyridine, Cyclohexanone, Cellosolve, Acetic acidHazyAcetone, Tertiary butanol , Dioxane, Cyclohexanol, Cyclohexanol, Lactic acid, Methyl ethyl ketoneInsolubleAliphatic hydrocarbons, Benzene, Xylene, Glycerin, Toluene, GasolineTechNical data sheeTDaTasheeT #:TDS-01hpc GradesORHydroxypropyl Cellulose(cellulose, 2-hydroxypropyl ether)HORCH2 ORCH2 OROOOOHHORORHHHHHH R : -HCH3 HmCH2CH0orCAS No.

2 9004-64-2chemical structureAqueous SolutionDispersionHEATING >> << COOLINGLCST = Lower Critical Solution TemperatureLCST44~46 CHPC-L at 20 CHPC-L at 50 CFig 3: Viscosity change vs. Temperature, Aqueous solutionFig 6: Viscosity change vs. pHFig 4: Viscosity change vs. Temperature, Ethanol solutionFig 7: Viscosity change vs. Days lapsed under UV radiationFig 5: Phase transition effect is completely reversible upon cooling11020304010100 Viscosity (mPa s)Temperature ( C)100016050 HPC-MHPC-LHPC-SL1510152025100101000 Viscosity (mPa s)pH value10,000030 HPC-HHPC-MHPC-L 11020304010100 Viscosity (mPa s)Temperature ( C)100016050 HPC-HHPC-MHPC-L & SL014711201030 Viscosity (mPa s)pH value40014 HPC-HHPC-MHPC-L HPC-SL123456101001000 Viscosity (mPa s)Concentration (%)100,00010,000110897 HMLSLSSL123456101001000 Viscosity (mPa s)Concentration (%)100,00010,000110897 HMLSLSSLFig 1.

3 Viscosity change vs. Concentration, Aqueous solutionFig 2: Viscosity change vs. Concentration, Ethanol solutionViscosity changeViscosity of HPC in aqueous solution is virtually unchanged in pH range from 1-12. HPC viscosity is also unaffected by UV irradiation. Viscosity change caused by change in HPC concentration or change in temperature are shown in figures Copyright 2011 Nisso HPCN oticeThe information described in this sheeT is believed to be accurate and are presented in good faith with no guarantee or obligation as to accuracy and no assumption of liability.

4 Users should make their own tests to determine the suitability of products for their own particular use. Nisso makes no warranty of any kind, express or implied, including those of merchantability and fitness for particular purpose other than the material conforms to its applicable current standard America Broadway, Suite 2120 New York, New York 10006(T) 212-490-3050(F) Chemical Europe, GmbHBerliner Allee 42, 40212 Duesseldorf, Germany(T) +49-(0)-211-1306686-0(F) +49-(0) OfficeNippon Soda Co., Ltd2-1 2-Chome, OhtemachiChiyoda-ku, Tokyo 100-8165 Japan(T) 81-3-3245-6159(F) HPC contains no silica or other statusUSP/NF, EP, JP compliant.

5 Food use approved 21 CFR , E463expirationExpiration date is (3) years from date of and chemical propertiessoftening TemperatureSpecific gravity (particles) temperature195-210 CCharring temperature260-275 CSoftening temperature ( C)1st transition2nd transitionHPC-H73164 HPC-M68178 HPC-L60185 HPC-SL68192 HPC-SSL75183hpc-sslhpc-slhpc-lhpc-mhpc-h Bulk density loose (g/cc) density tapped(g/cc) (%) of repose(Degree)4946454240 Particle size (D50)( m)50-7070-90100-120130-150130hpc-sFphpc- sl (Fp)hpc-l (Fp)hpc-m (Fp)hpc-h (Fp)Bulk density loose (g/cc) density tapped(g/cc) (%) of repose(Degree)5047474644 Particle size (D50)( m)< 2060-8060-8060-8050-70powder characteristicsmoisture UptakeFig 8: Moisture uptake at 50% and 80% relative humidity01234628410121416 Moisture content (%)Days elapsed (days)18065 HPC-L, SLHPC-M80% RH50% RHpackagingNisso HPC is available in a 10kg of manufactureNippon Soda Co.

6 , Ltd. Nihongi Plant 350 Fujjisawa, Joetsu city Niigata prefecture, Japa