TEOXANE PRESS FILE TEOSYAL PURESENSE …

1 TEOXANE PRESS FILE My skin is not just quite the way it used to It lost its natural glow and hydration. And I hate being told I look dull all the time. I want to feel pretty again and regain confidence in myself! Helen, 32 TEOSYAL PURESENSE REDENSITY [I]: SKIN REDENSIFIER & GLOW ENHANCER Age, stress, hormonal imbalance (post-birth, ) as well as sun, tobacco and an unhealthy lifestyle are all factors involved in skin aging. With time, lines develop, complexion turns dull, the skin texture becomes uneven and wrinkles appear. All these changes create dark areas on the face and the skin gradually loses its glow and becomes dry, thin and fragile. Young skin Aged skin Loss of hyaluronic acid and excessive oxidative stress are the main reasons of skin aging: hyaluronic acid is an essential skin component.

2 It acts like a sponge that retains water and keeps the skin moisturized, plumped and healthy. As far as oxidative stress is concerned, the balance between detoxifying molecules (antioxidants) and toxic elements (oxidants) can be disturbed by many external factors. The excess of oxidants attacks the skin decreasing its elasticity and tonicity. Thanks to TEOXANE Laboratories and TEOSYAL PURESENSE Redensity [I], it is now possible to restore this balance by adequately nourishing the skin from within. TEOSYAL PURESENSE Redensity [I] is a unique hyaluronic acid -based skin enhancer which prevents premature skin aging, restores skin density and maintains skin glow. AN EXCLUSIVE FORMULA DESIGNED FROM A RIGOROUS SELECTION OF NON-ALLERGENIC INGREDIENTS: hyaluronic acid DERMO-RESTRUCTURING COMPLEX LIDOCAINE + + TEOXANE PRESS FILE A UNIQUE AND EXCLUSIVE FORMULA hyaluronic acid High concentration of free hyaluronic acid .

3 15mg/g Optimal spreading properties For dermal deep rehydration and redensification DERMO-RESTRUCTURING COMPLEX 3 highly efficient and powerful antioxidants, 2 minerals, 1 vitamin and 8 amino acids selected for their pharmaceutical grade, non-allergenic properties and compatibility with hyaluronic acid1 A selection of natural, non-allergenic and synergic ingredients For efficient skin protection and redensification LIDOCAINE Local anesthetic For better patient comfort during the injection TEOSYAL PURESENSE Redensity [I] exclusive formula is available: in a 1 x 3ml version for a face targeted protocol in a 2 x 1ml version for an extended face, neck and neckline protocol BEFORE 1 Antioxidants: Glutathione, N-Acetyl-L-Cysteine, Alpha Lipoic acid .

4 Minerals: Zinc, Copper. Vitamin: B6. Amino acids: Arginine, Glycine, Lysine, Threonine, Proline, Isoleucine, Leucine, Valine. FREE hyaluronic acid 15mg/g DERMO-RESTRUCTURING COMPLEX LIDOCAINE + + Immediately after 2 sessions of TEOSYAL PURESENSE Redensity [I] Quantity injected per session: 2ml Source: Dr Fabien GIAUSSERAN, France Source: Dr Fabien GIAUSSERAN, France Source: Dr Fabien GIAUSSERAN, France TEOXANE PRESS FILE THE DERMO-RESTRUCTURING COMPLEX TO REGAIN ENERGY IN THE DERMIS TEOSYAL PURESENSE Redensity [I] Dermo-Restructuring Complex combines natural components all synergically involved in redensifying the dermis and providing antioxidant protection: 3 potent antioxidants, 2 minerals, 1 vitamin and 8 amino acids. The Patented Dermo-Restructuring Complex induces: The restructuration of the dermis and a cellular regeneration: + 98% of collagen-IV2 and + 26% of fibrillin-12 A strong improvement of the cutaneous hydration: 15 times more acidic GAGs2 in the epidermis An antioxidant protection: - 28% of the photo-induced oxidative stress 2 Evaluation of TEOSYAL PURESENSE Redensity [I] efficacy on biological aging markers: Study carried out by an independent laboratory, based on a protocol specially drawn up by TEOXANE , consisting in injecting a bolus of product into the upper reticular dermis of a skin explant kept alive.

5 This skin model displays the beneficial effects of TEOSYAL PURESENSE Redensity [I] on biological markers of skin aging in an accelerated way over 9 days. Glossary: Collagen-IV & GAGs (Glycosaminoglycans): essential for skin structure. Fibrillin-1: essential for the formation of elastic fibers. = REDENSIFICATION OF THE DERMIS2 TEOXANE PRESS FILE VISIBLE EFFICACY OF TEOSYAL PURESENSE REDENSITY [I] SUBTLE, IMMEDIATE AND CUMULATIVE RESULTS BEFORE TEOSYAL PURESENSE Redensity [I] treatment consists in performing microinjections across the dermis, so that hyaluronic acid and the Dermo-Restructuring Complex are spread evenly into the skin. Three sessions at three week intervals are recommended for optimal cutaneous redensification. Two to three sessions per year are recommended to maintain the effects of the treatment3.

6 TEOSYAL PURESENSE Redensity [I] is suitable for the face, neck and also neckline which is a particularly fragile area often ignored by traditional treatments. TEOSYAL PURESENSE Redensity [I] guarantees subtle, uniform and cumulative results: the skin is evenly and naturally plumped, radiant and smooth with luminosity restored. About TEOXANE Laboratories TEOXANE Laboratories were established in Geneva in 2003 and are specialized in the design and manufacture of hyaluronic acid -based dermal fillers. As a result of its uncompromising commitment to innovation, quality and patient satisfaction, TEOXANE is now among the top three hyaluronic acid -based dermal fillers manufacturers in the world with products in more than 80 countries. For more information, please visit PRESS CONTACT Pauline B roard, Communications Officer E-mail: Phone: +33 1 44 40 88 90 3 Multicentre study of TEOSYAL PURESENSE Redensity [I] efficacy, with a protocol of 3 sessions at 3 week intervals and a checkup visit 1month after the third session, Dr Carr , Dr Vivier (France); Dr Knoll (Germany), 42 patients, April 2011.

7 TEOSYAL PURESENSE REDENSITY [I]: The global care to fight against dryness, cutaneous slackening, skin tightening, sun exposure and aging process TEOXANE Data Source TEOXANE Data Source Results 1 month after the third session TEOSYAL PURESENSE Redensity [I] 3 Technique: multi-bolus Quantity injected per session: 2 ml