Transcription of The Use of WinNonlin for Determining Basic …
1 The Use of WinNonlin for The Use of WinNonlin for Determining Basic Determining Basic Pharmacokinetic Pharmacokinetic ParametersParametersBy Christopher J. Kemper, Christopher J. Kemper, , LLCN avigators, LLCO verviewOverview Basic concepts in Pharmacokinetics Basic concepts in Pharmacokinetics and the Big 7and the Big 7 The origins of The origins of NonlinNonlin Citrix space Citrix space Available manuals and publicationsAvailable manuals and publications Step by step processing of a sample Step by step processing of a sample data setdata setPharmacokinetic parameters : Pharmacokinetic parameters : Non CompartmentalNon Compartmental CCmaxmax, , TTmaxmax, AUC, AUC AUC = AUC = C C dtdt Dose/AUC = Dose/AUC = ClClsyssys= = Vol_DistVol_Distx x zz HalflifeHalflife= / = / zz MRT = AUMC/AUCMRT = AUMC/AUC AUMC = AUMC = tCtCdtdt The mean residence time represents the The mean residence time represents the time for of the dose to be time for of the dose to be eliminatedeliminat