一般外来で見逃してはいけない ... - thyroid.jp

1 TSH 39 19 9 28 TSH FT3, FT4, TSH TgAb TSH TSH 1956 51 Long-acting thyroid stimulator (LATS) LATS TSH TSH TSH Binding Inhibiting Immunoglobulin; TBII TRAb (TSH Receptor Antibody) cAMP thyroid Stimulating Antibody.

2 TSAb TSH thyroid stimulation Blocking Antibody (TSBAb) TRAb TSAb FT3, FT4 TRAb, TSAb TRA TSA TRAb TSAb TSH TSH TRAb TRAb TSAb MoAb TSH TRAb

3 853 (80%) 5 ( ) 0 10 ( ) 0 0 0 89 ( ) 110 ( ) 0 853 (80%) 5 ( ) 0 10 ( ) 0 0 0 89 ( ) 110 ( ) 0 10 TSH TRAb --10100010102020303040405050606070708080 9090100100 AFTNAFTN TMNGTMNGTRAb CTTRAb CT (%)(%) TRAb (TRAb CT)

4 3rd2nd 48 481 2002 59/60 51 839 2003 100 40/40 48:711(2002)100 57/57 Kamijo Journal 52:525(2005) (243/244) (242/244) TRAb (TRAb ) TRAb human Meller et al. Nuklearmedizin 2000 10 100 %Maugendre et al. Clin Endocrinol 2001 140 99 %Massart et al. Clinica Chemica 90 99 %Pedersen et al. Clin Endocrinol 2001 106 95 %Zimmerman-Belsing Eur J Endocrinol 2002 122 99 %TRAb TRAb TRAb TRAb TRAbCT 20% TRAb 98 1-2% TRAb FT3/FT4 02460246810FT4FT3/FT4 TRAb

5 TRAb TRAb TRAb TRAb TRAb 6 TRAb TRAb TRAb >10) 2 TRAb M. Schott Horm Metab Res 2004 TRAb TRAb TRAb TRAK Massart2001 (18M 36M) 50 66 %34 P< 404060 Maugendre2001 (18M, 36M) 927426P< 482575 Glinoer2001 (15M, 12M) 647822P< 101090 Zimmermann2002 (18M, 18M) 786238ns 514555 Wallaschofski2002 (>12M, 26M)

6 196832P< 353169 314 68 32 P< 18434 64 TRAb TRAb TRAb TRAb TRAb 6 TSH TRAb / 3 71 TRAb TRAb 0510152025303540 III CT % DYNO IU/L III CT DYNO TRAbIII TRAb TRAbCT 30% TRAb TRAb 20%40%60%80%100%0369122436 ATD DYNOCTTRAb TRAb 71 2 6 3 20 75% 65% 65% 75% TRAb TRAb TRAbCT 30% TRAb TRAb TRAb.

7 3 TRAb 0123 TRA h IU/mL TSH IU/mL FT4 Ng/ L 3 6 9 TRAb TRA h IU/mL TSH IU/mL FT4 Ng/ L TRAb 6 TRAb TRAb 020040060080010001200010203 / /6 1410 TRAb TRAb TRAb TRAb TRAb TRAb FT3.

8 FT4 TRAb 0123 TRA h IU/mL TSH IU/mL FT4 Ng/ L 3 6 9 TRAb 0123010203040 3 6 9 12 0123 h IU/mL TSH IU/mL FT4 Ng/ L h IU/mL TSH IU/mL FT4 Ng/ L H10 H19 1 < TRAb TRAb TRAb 0246810121416 TRAb TRAb TRA human IU/mL < 02468101214 TRAb TRAb TRA human IU/mL TRAb TRAb 230%TRAb 100 TRAb TRAb TRAb TRAb TRAb TRAbh 3 TRAb Tagami T et al.

9 thyroid 17, 2007 23 11 16 TRAb TRAb TRAbIII >50% TRAb CT > 70%TRAb human > RI TRAb TRAbIII 50% TRAbIII TSH TRAb

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