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1 7 5 2012 7-13 1 2 1, 2 11 2 1 2 MUC5AC MUC6 CD10 MUC2 3-5 1997 40 43

2 40 43 CD10 p = 0. 014 15 9 8 5 2012 66. 6 24 16 22 25 18 18 15 1 3mm CD10 56C6, Leica Microsystems, Tokyo, Japan MUC2 Ccp58, Leica Microsystems MUC5AC CLH2, Leica Microsystems MUC6 CLH5.

3 Leica Microsystems 1% PBS pH7. 4 Vector Laboratories, Burlingame, US CD10 800 MUC2 400 MUC5AC 2000 MUC6 800 4 C PBS Universal Elite ABC kit Vector Laboratories ABC ImmPACT DAB Peroxidase Substrate Vector Laboratories PBS 10% MUC5AC, MUC6 G type CD10.

4 MUC2 I type M type MG type MI type <10% N type 1 43 CD10 12 MUC2 23 MUC5AC 26 MUC6 16 10 G type 12 MG type 10 I type 6 MI type 5 N type 1 1 CD10 MUC2 MUC5AC MUC6 25 9 14 18 11 18 3 9 8 5 G type MG type G type MG type 15 7 2 3 CD10 MUC2 MUC5AC MUC6 20 10 11 12 8 20 2 9 45.

5 0% 11 5 9 1 2 10 5 2012 CD10 Fisher , p= I type MI type I type MI type 10 5 25. 0% N type 15 CD10 MUC2 MUC5AC MUC6 15 3 8 8 5 15 3 5 33. 3% 5 1 CD10 9 60% 2 G MG, I MI 3 20.

6 0% N type 1 6. 7% MG type MI type 3 G type MG type 6, 7 I type MI type 9/25, 36. 0% 7/18, 38. 9% CD10 I type MI type N type CD10 CD10 CD10 2 3 11 CD10 2 CD10 Lauren8 1

7 Intestinal-type Diffuse-type Lauren Intestinal-type N type CD10 N type 9 65% GI MG type MI type 60% 9/15 N type CD10 N type 1 Nakamura K, Sugano H, Takagi K.

8 Carcinoma of the stomach in incipient phase: its histogenesis and histological appearances. Gann 1968; 59: 251-2582 3 20103 Toki F, Takahashi A, Aihara R, Ogata K, Ando H, Ohno T, et al. Relationship between clinicopathological features and mucin phenotypes of advanced gastric adenocarcinoma. World J Gastroenterol 2010 June;16 22 2764-27704 Wakatsuki K, Yamada Y, Narikiyo M, Ueno M, Takayama T, Tamaki H, et al. Clinicopathological and prognostic significance of mucin phenotype in gastric cancer. J Surg Oncol. 2008 Aug 98 2 124-95 Nakamoto J, Torisu R, Aoki R, Kimura Y, Yasuda M, Shiota K, et al.

9 Clinicopathological evaluation of biological behavior of submucosal invasive gastric carcinomas: relationship among lymph node metastasis, mucin phenotype and proliferative activity. J Med Invest. 2007 Fed; 54 1-2 99-1086 Yamachika T, Inada K, Fujimitsu Y, Nakamura S, Yamamura Y, Kitou T, et al. Intestinalization of gastric signet ring cell carcinomas with progression. Virchows Arch. 1997 Aug; 431 2 103-107 Yoshikawa A, Inada Ki, Yamachika T, Shimizu N, Kaminishi M, Tatematsu M. Phenotypic shift in human differentiated gastric cancers from gastric to intestinal epithelial cell type during disease progression. Gastric Cancer. 1998 Mar; 1 2 134-1418 Lauren P.

10 The two histological main types of gastric carcinoma: diffuse and so-called intestinal type carcinoma. APMIS 1965; 64: 31-499 Htoo Zarni Oo perspective 2010 3 4 256-261 12 5 2012 1 HE a CD10 b MUC2 c MUC5AC d MUC6 200 13 Expression of Gastrointestinal Phenotypic Marker in Gastric AdenocarcinomaToshinori Kozu1, Takayuki Seki2, Tetsuo Yamada1, 2, Morio Koike11 Graduate School of Health Care Science, bunkyo Gakuin University2 Department of Clinical Laboratory Medicine, Faculty of Health Science Technology.