US EPA - Pesticides - Fact Sheet for Pendimethalin

1 UnitedStatesPrevention,PesticidesEPA-738 -F-97-007 EnvironmentalProtectionAndToxicSubstance sJune1997 Agency(7508W) FACTSP endimethalinPesticideReregistrationAllpe sticidessoldordistributedintheUnitedStat esmustberegisteredbyEPA, ,thelawrequiresthatpesticideswhichwerefi rstregisteredbeforeNovember1,1984,berere gisteredtoensurethattheymeettoday' ,EPAobtainsandreviewsacompletesetofstudi esfrompesticideproducers, ,EPAconsidersthespecialsensitivityofinfa ntsandchildrentopesticides,aswellasaggre gateexposureofthepublictopesticideresidu esfromallsources, ' , ,EPAexplainsthebasisforitsdecisioninaRer egistrationEligibilityDecision(RED) , ,solid,granular,emsulsifiableconcentrate , ,chemigation,conservationtillage,contain erizedplanttreatment,soilincorporation, (PB86-172814).AOctober1990 DataCall-In(DCI)requiredadditionalproduc tandresiduechemistry,toxicology, , , (thesecondlowestoffourcategories) (thelowestoffourcategories).

2 ( ). ,exposurefromallcurrentpendimethalintole rancesrepresentslessthan1%oftheReference Dose(RfD), ,non-nursinginfants,representslessthan2% , ,handlers(mixers,loaders,andapplicators) ,butcausesthyroidfollicularcelladenomasi nmaleandfemaleratsandhasbeenclassifiedas aGroupC, ;however,dietaryexposuretopendimethalinr esiduesinfoodsisextremelylow, ,feed,fiber,ornamental,turf,rights-of-wa yandothernoncroptreatments;andhomeownerh andlersmakingapplicationstoresidentialtu rf. Occupational/ShortandIntermediateTerm:Ag encycalculationsindicatethatMarginsofExp osure(MOEs)forhandlerswearingbaselineatt ire(long-sleeveshirt,longpants,shoesands ocks)areacceptable(over100)forallbutthre escenarios:(1)mixing/loadingliquidforaer ialapplicationsandirrigationsystems,(2)m ixing/loadingliquidforrights-of-wayspray ing,and(3) (MOEsrangefrom110to33,333) :TheAgencyhasdeterminedthattherearerisks followingapplicationstocommercialorresea rchfood,feed,fiber,turf, (REIs) ,theAgencyisrequiringthatthe12-hourinter imREIbeincreasedto24hoursforallpendimeth alinuseswithinthescopeoftheWorkerProtect ionStandard(WPS).

3 However,REIsaregenerallynotfeasibleasami tigationmeasureforoccupationalexposuresi nnoncropareas(suchasrights-of-way).There fore,asariskmitigationmeasure,theAgencyi srequiringareductioninthemaximumuseratef rom3lbsactiveingredient(ai) :Again,REIsarenotpracticalorfeasibleforr esidentialorrecreationalturf;consequentl y, , ,EPAhasconsideredtheavailableinformation onaggregateexposures(bothacuteandchronic )fromnon-occupationalsources, ;therefore,theconsiderationsforaggregate exposurearethosefromfood,drinkingwater, (TMRC)are<1% (datafrom8stateswith2stateswithdetectabl eresidues), ,theestimatedrisksfromwaterare<2%RfDfora llpopulationsubgroups, ,EPAdoesnothave,atthistime, , ,therefore, , , , (cottonandsoybeans) ,orinrunofffromrainfalleventsandthroughi rrigationwaters(chemigation).However, (atverylowlevels), (LOCs) ,pendimethalindoesnotrepresentahighriskt oaquaticanimalsandplants, ,aquaticplantsandinvertebratesincludingm ollusks,fish,andbirds(specificallygrazer s).

4 ,EPAisrequiringthefollowingriskmitigatio nmeasures:Foroccupationalhandlers/usesit es:5increaserestrictedentryintervalfrom1 2to24hours;addchemicalresistantgloves; :postapplicationreentrystudies(guideline s132-1a,b), (61-1through61-3,62-2,62-3),magnitudeofr esiduefortobaccoandcottonginbyproducts(1 71-4k),processingforrice(171-4l),avianch ronic(71-4),fielddissipationforcottonand soybeans(164-1),andaquaticdissipationfor rice(164-2).TheAgencyalsoisrequiringprod uct-specificdataincludingproductchemistr yandacutetoxicitystudies,revisedConfiden tialStatementsofFormula(CSFs), RequiredAllpendimethalinend-useproductsm ustcomplywithEPA' , (baseline) (baseline)PPEforoccupationalusesofpendim ethalinend-useproductsare:Foremulsifiabl econcentrateformulations:Mixersandloader smustwear:--long-sleevedshirtandlongpant s,--chemical-resistantgloves,and--shoesp lussocksForwater-dispersiblegranule,wett ablepowder,andemulsifiableconcentratefor mulationswhoseusedirectionsreasonablyper mitapplicationusinghand-heldsprayers:6 CommercialHandlers(mixers,loaders,andapp licators)whoapplythisproductusinghand-he ldequipmentorhoses(notincludinghosesatta chedtotruck-mountedequipment)mustwear:-- long-sleevedshirtandlongpants,--chemical -resistantgloves,and--shoesplussocksRest ricted-entryinterval.

5 A24-hourrestricted-entryinterval(REI)isr equiredforusesonfood,feed,fiber,ornament al,forestry, :iftheproductissoil-injectedorsoil-incor porated,theWorkerProtectionStandard,unde rcertaincircumstances, :Forresidentiallawnandsodfarmuses: NonWPSusesForliquidapplications:"Donoten terorallowotherstoenterthetreatedareaunt ilsprayshavedried."Fordryapplications:"D onotenterorallowotherstoenterthetreateda reauntildustshavesettled."ProductsIntend edPrimarilyforHomeownerUseEntryrestricti ons:TheAgencyisestablishingthefollowinge ntryrestrictionsforallhomeownerusesofpen dimethalinend-useproducts(NOTE:Thispresu mestheregistrantreducesthemaximumapplica tionrateforturfatresidentialsitesandpark sandrecreationareastotwopoundsactiveingr edientperacre.):Forliquidapplications:"D onotallowpeopleorpetstotouchtreatedplant suntilthesprayshavedried."Fordryapplicat ions:"Donotallowpeopleorpetstoenterthetr eatedareauntildustshavesettled." "Donotapplythisproductinawaythatwillcont actworkersorotherpersons, "EngineeringControls"Whenhandlersuseclos edsystems,enclosedcabs,oraircraftinamann erthatmeetstherequirementslistedintheWor kerProtectionStandard(WPS)foragricultura lpesticides( )(d)(4-6),thehandlerPPErequirementsmaybe reducedormodifiedasspecifiedintheWPS.

6 "ApplicationRestrictions"Donotapplythisp roductinawaythatwillcontactworkersorothe rpersons, "EngineeringControls"Whenhandlersuseclos edsystems,enclosedcabs,oraircraftinamann erthatmeetstherequirementslistedintheWor kerProtectionStandard(WPS)foragricultura lpesticides( )(d)(4-6),thehandlerPPErequirementsmaybe reducedormodifiedasspecifiedintheWPS."Pr oductsIntendedPrimarilyforHomeUseApplica tionRestrictions"Donotapplythisproductin awaythatwillcontactanypersonorpet, "UserSafetyRecommendations"Usersshouldwa shhandsbeforeeating,drinking,chewinggum, usingtobacco,orusingthetoilet."" "EnvironmentalHazardsStatement Donotapplydirectlytowater, 8 ApplicationRatesThelabelsofallpendimetha linend-useproductsmustberevisedtobearthe followingapplicationratefortherespective uses:Forresidentiallawnandsodfarmuses: , ,revisedConfidentialStatementsofFormula, (RED)documentforpendimethalinduringa60-d aytimeperiod, ,pleasecontactthePesticideDocket,PublicR esponseandProgramResourcesBranch,FieldOp erationsDivision(7506C),OfficeofPesticid ePrograms(OPP),USEPA,Washington,DC20460, ,orusingWWW(WorldWideWeb) 'sNationalCenterforEnvironmentalPublicat ionsandInformation(EPA/NCEPI),POBox42419 ,Cincinnati,OH45242-2419,telephone1-800- 490-9198, ,thependimethalinREDdocumentalsowillbeav ailablefromtheNationalTechnicalInformati onService(NTIS),5285 PortRoyalRoad,Springfield,VA22161, 'spesticidereregistrationprogram,thepend imethalinRED,orreregistrationofindividua lproductscontainingpendimethalin,pleasec ontacttheSpecialReviewandReregistrationD ivision(7508W),OPP,USEPA,Washington,DC20 460, ,orforassistanceinrecognizingandmanaging pesticidepoisoningsymptoms,pleasecontact theNationalPesticidesTelecommunicationsN etwork(NPTN).

7 Calltoll-free1-800-858-7378,between9:30a mand7:30pmEasternStandardTime,Mondaythro ughFriday.