What to Expect With CombiPatch

1 Cyclic regimenIf your doctor has prescribed a cyclic regimen, you will use Vivelle-Dot (estradiol transdermal system) for the first two weeks of your cycle and CombiPatch for the second two weeks of your cycle. The calendar to the right shows when you ll apply a new transdermal patch to your lower abdomen throughout the 4-week schedule. While following a cyclic regimen monthly bleeding often to Expect With CombiPatch IMPORTANT SAFETY INFORMATIONDo not use estrogens and progestins to prevent heart disease, heart attacks, strokes or dementia (decline in memory and thinking skills). Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, and blood clots, and may increase your risk of dementia. Do not use CombiPatch if you have had your uterus removed (hysterectomy).

2 CombiPatch should not be used if you have unusual vaginal bleeding; currently have or have had certain cancers, including cancer of the breast or uterus; had a stroke or heart attack in the recent past (for example, in the past year); currently have or have had blood clots; currently have or have had liver problems; or think you may be, or know that you are, Click Here for Full Prescribing Information, including Boxed WARNINGS, for CombiPatch . Please Click Here for Full Prescribing Information, including Boxed WARNINGS, for Vivelle-Dot. CombiPatch and Vivelle-Dot are available by prescription hormones in CombiPatch and Vivelle-Dot are chemically derived from plant sources. This does not mean that CombiPatch or Vivelle-Dot is safer or more effective than other hormone offers effective menopause symptom relief with smaller daily doses as compared to pills.

3 That s because the hormones in CombiPatch pass directly through the skin and into your bloodstream, avoiding the digestive tract and liver metabolism. This does not mean that CombiPatch is safer or more effective than pill therapy. Did you know?Continuous regimenIf your doctor has prescribed a continuous regimen, you will use CombiPatch only. The calendar to the right shows when you ll apply a new transdermal patch to your lower abdomen throughout a 4-week schedule. While following a continuous regimen you may experience spotting in the first year. The spotting will usually decrease during the first year. CombiPatch is used after menopause to reduce moderate to severe hot more aboutmenopause andhormone therapy schedule12345678910121311141516171920182 12223242627 Combi-PatchCombi-PatchCombi-PatchCombi-P atchCombi-PatchCombi-PatchCombi-PatchCom bi-Patch25284-week schedule12345678910121311141516171920182 12223242627 Combi-PatchCombi-PatchCombi-PatchCombi-P atch2528 Vivelle- DotVivelle- DotVivelle- DotVivelle- DotVivelle-Dot (estradiol transdermal system)INDICATIONV ivelle-Dot is used after menopause to: reduce moderate to severe hot flashes; treat moderate to severe dryness, itching and burning in or around the vagina; help reduce your chances of getting osteoporosis (thin weak bones).

4 And treat certain conditions in which a young woman s ovaries do not produce enough estrogens naturally. Vivelle-Dot mg/day is only used to prevent osteoporosis from menopause. If you use Vivelle-Dot only to treat your dryness, itching, and burning in and around your vagina or if you use Vivelle-Dot only to prevent osteoporosis from menopause, talk with your healthcare professional about whether a different treatment or medicine without estrogens might be better for you. IMPORTANT SAFETY INFORMATIONE strogens increase the chances of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are taking estrogens. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Do not use estrogens with or without progestins to prevent heart disease, heart attacks, or strokes.

5 Using estrogens with or without progestins may increase your chances of getting heart attacks, strokes, breast cancer, and blood clots. Using estrogens with progestins may increase your risk of dementia (decline in memory and thinking skills).Vivelle-Dot should not be used if you have unusual vaginal bleeding; currently have or have had certain cancers, including cancer of the breast or uterus; had a stroke or heart attack in the recent past (for example, in the past year); currently have or have had blood clots; currently have or have had liver problems; or think you may be, or know that you are, most common side effects that may occur with Vivelle-Dot are headache, breast tenderness, and back pain. You and your healthcare professional should talk regularly about whether you still need treatment with Click Here for Full Prescribing Information, including Boxed WARNINGS, for Vivelle-Dot.

6 Available by prescription are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088. CombiPatch (estradiol/norethindrone acetate transdermal system)INDICATIONC ombiPatch is used after menopause to: reduce moderate to severe hot flashes; treat moderate to severe dryness, itching and burning in or around the vagina; and treat certain conditions in which a young woman s ovaries do not produce enough estrogens naturally. If you use CombiPatch only to treat your dryness, itching and burning in or around the vagina, talk with your healthcare professional about whether a topical vaginal product would be better for you. IMPORTANT SAFETY INFORMATIONDo not use estrogens and progestins to prevent heart disease, heart attacks, strokes or dementia (decline in memory and thinking skills).

7 Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, and blood clots, and may increase your risk of dementia. Do not use CombiPatch if you have had your uterus removed (hysterectomy). CombiPatch should not be used if you have unusual vaginal bleeding; currently have or have had certain cancers, including cancer of the breast or uterus; had a stroke or heart attack in the recent past (for example, in the past year); currently have or have had blood clots; currently have or have had liver problems; or think you may be, or know that you are, most common side effects that may occur with CombiPatch are breast pain, vaginal bleeding, and and your healthcare professional should talk regularly about whether you still need treatment with CombiPatch and whether you are taking the lowest dose that works for Click Here for Full Prescribing Information, including Boxed WARNINGS, for CombiPatch .

8 Available by prescription are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088. 2010 Novartis Printed in 07/10 CBP-900128