World Organisation for Animal Health (OIE), 2018

1 W o r l d O r g a n i s a t i o n f o r A n i m a l H e a l t h ( O I E ) , 2 0 18 12 rue de Prony 75017 Paris, France Tel.: 33 (0)1 44 15 18 88 Fax: 33 (0)1 42 67 09 87 1 Table of Contents DIRECTOR GENERAL S FOREWORD .. 7 EXECUTIVE SUMMARY .. 9 ACKNOWLEDGEMENTS .. 11 ACRONYMS AND ABBREVIATIONS .. 12 OIE GLOSSARY .. 13 1. INTRODUCTION .. 15 Background .. 15 Scope .. 18 2. MATERIALS AND METHODS .. 19 Antimicrobial Quantities Reported .. 19 Animal Biomass Estimation Methodology .. 20 Antimicrobial Quantities Adjusted for Animal Biomass .. 25 3. RESULTS OF THE THIRD ROUND OF DATA COLLECTION .. 25 Global Analysis .. 25 Antimicrobial Quantities .. 36 Analysis by OIE Region .. 50 4. FOCUS ON 2015 : ADDITIONAL ANALYSIS OF ANTIMICROBIAL QUANTITIES.

2 55 Antimicrobial Quantities .. 55 Animal Biomass .. 59 Antimicrobial Quantities Adjusted by Animal Biomass .. 65 5. DISCUSSION .. 68 Progress Made by Member Countries .. 68 Limitations in the Analysis of Antimicrobial Quantities .. 69 Limitations in the Estimation of Animal Biomass .. 70 Barriers to Collect Antimicrobial Quantities .. 72 6. FUTURE DEVELOPMENTS FOR THE ANTI-MICROBIAL USE 72 7. 73 8. REFERENCES .. 74 9. COUNTRY INFORMATION AVAILABLE ON THE WEB .. 77 ANNEXES .. 79 Annex 1. Africa, Responses from the Third Round of Data Collection .. 81 Annex 2. Americas, Responses from the Third Round of Data Collection .. 88 Annex 3. Asia, Far East and Oceania, Responses from the Third Round of Data Collection .. 94 Annex 4. Europe, Responses from the Third Round of Data Collection.

3 100 Annex 5. Middle East, Responses from the Third Round of Data Collection .. 106 Annex 6. OIE Template .. 108 2 Annex 7. Guidance for Completing the OIE Template for the Collection of Data on Antimicrobial Agents Used in Animals .. 113 Annex 8. Annex to the guidance for completing the OIE template for the collection of data on antimicrobial agents used in animals .. 123 Annex 9. Distribution of Member Countries by OIE Region .. 129 LIST OF TABLES Table 1. Baseline Information Sections and How Countries Respond Based on Available Data .. 26 Table 2. Breakdown of Country Response Types in Third Round of Data Collection .. 36 Table 3. Estimation of Quantitative Data Not Captured Based on Lack of Access to Sources, as Reported by 40 Countries in the Third Round of Data Collection.

4 40 Table 4. Antimicrobial Classes with More than 70% of the Total Amount of Antimicrobials Intended for Use in Animals, by 15 Countries During the Third Round of Data Collection .. 50 Table 5. Number of Countries that Responded to the OIE Survey in the Third Round of Data Collection, by OIE Region .. 50 Table 6. Reported Quantity of Antimicrobial Agents Intended for Use in Animals by OIE Region, 2015 .. 59 Table 7. Animal Biomass Covered by Quantitative Data Reported to the OIE for 2015 Obtained by the Accumulation of Information from All 3 Rounds of Data Collection, Results for 91 Countries .. 60 Table 8. Animal Biomass Covered by Quantitative Data Reported to the OIE for 2015 , Regional Results for 91 Countries .. 61 Table 9. Antimicrobial Quantities Adjusted by Animal Biomass, by OIE Region, 2015 .

5 67 Table A1. General Information for Africa .. 81 Table A2. General Information for the Americas .. 88 Table A3. General Information for Asia, Far East and Oceania .. 94 Table A4. General Information for Europe .. 100 Table A5. General Information for the Middle East .. 106 LIST OF FIGURES Figure 1. Contact Person Profile of 153 Member Countries that Submitted the OIE Report in 2017 .. 26 Figure 2. Number of Countries Participating in All Rounds of the Data Collection .. 27 Figure 3. Reporting Option Used by 155 Countries in the Third Round of Data Collection .. 28 Figure 4. Country Barriers to Reporting Quantitative Data on Antimicrobial Agents Intended for Use in Animals in 31 Countries in the Third Round of Data Collection .. 29 Figure 5a. Use of Antimicrobial Growth Promoters in 155 Countries in 2017.

6 32 Figure 5b. Use of Antimicrobial Growth Promoters by Legislation, in 155 Countries in 2017 .. 33 Figure 6. Type of Legislation for Growth Promotion in 45 Countries that Reported the Use of Growth Promoters in 2017 .. 34 Figure 7. Antimicrobial Agents Used for Growth Promotion in Animals in 30 Countries in 2017 .. 35 Figure 8. Years of Quantitative Data Reported in Third Round of Data Collection, from 127 Responses Provided by 118 Countries .. 37 Figure 9. Validated Data Sources Selected by 94 Countries Reporting Quantitative Data from 2015 to 2017 .. 38 3 Figure 10. Other Source of Data Described by 10 Countries Reporting Quantitative Data from 2015 to 2017 .. 39 Figure 11. Differentiation by Animal Groups Among 118 Countries Reporting Quantitative Data from 2015 to 2017.

7 41 Figure 12. Representation of Quantitative Data from 55 Countries Able to Distinguish by Animal Group from 2015 to 2017 .. 42 Figure 13. Food-Producing Animal Species Included in Quantitative Data Reported by 117 Countries from 2015 to 2017 .. 43 Figure 14. Aquatic Food-Producing Animal Species Included in Quantitative Data Reported by 62 Countries from 2015 to 2017 .. 44 Figure 15. Number of Countries Participating in All Rounds of the OIE Data Collection with National Reports Available on the Web .. 44 Figure 16. Proportion of Antimicrobial Quantities (by Antimicrobial Class) Reported for Use in Animals During the Third Round by 116 Countries from 2015 to 2017 .. 46 Figure 17a. Proportion of Antimicrobial Classes by Terrestrial Food-producing Animals as Reported by 33 Countries during the Third Round from 2015 to 2017.

8 47 Figure 17b. Proportion of Antimicrobial Classes by Aquatic Food-producing Animals as Reported by 9 Countries during the Third Round from 2015 to 2017 .. 48 Figure 17c. Proportion of Antimicrobial Classes by Companion Animals as Reported by 32 Countries during the Third Round from 2015 to 49 Figure 18. Percentage of Countries that Responded to the OIE Survey in the Third Round of Data Collection, by OIE Region .. 51 Figure 19. Regional Proportion of Contact Person of 153 Member Countries that Submitted the Response to the OIE Survey in the Third Round of Data Collection .. 52 Figure 20. Data Type Provided by 155 Countries Responding to the OIE survey in the Third Round of Data Collection, by OIE Region .. 53 Figure 21. Reporting Option Used to Provide Quantitative Data by 118 Countries in the Third Round of Data Collection, by OIE Region.

9 53 Figure 22. Number of Countries Using Antimicrobial Agents for Growth Promotion in Animals in 2017, of 155 Responding Countries, by OIE Region .. 54 Figure 23. Number of Countries Included in 2015 Analysis by OIE Region .. 56 Figure 24. Estimated Percentage of Total Regional Biomass Covered by Countries Reporting Quantitative Data for 2014 and 2015 .. 57 Figure 25. Countries Including Aquatic Food-Producing Animal Species in Quantitative Data for 2015 .. 58 Figure 26. Species Composition of Animal Biomass for 91 Countries Included in 2015 Quantitative Data Analysis .. 61 Figure 27. Species Composition of Animal Biomass for the 27 Countries in Africa Included in 2015 Quantitative Data Analysis .. 62 Figure 28. Species Composition of Animal Biomass for the 9 Countries in the Americas Included in 2015 Quantitative Data Analysis.

10 62 Figure 29. Species Composition of Animal Biomass for the 19 Countries in Asia, Far East and Oceania Included in 2015 Quantitative Data Analysis .. 63 Figure 30. Species Composition of Animal Biomass for the 36 Countries in Europe Included in 2015 Quantitative Data Analysis .. 63 Figure 31. Global Quantities of Antimicrobial Agents Intended for Use in Animals Based on Data Reported by 91 Countries for 2015 , Adjusted by Animal Biomass(mg/kg) .. 65 4 Figure 32. Quantities of Antimicrobial Agents Intended for Use in Animals Adjusted by Animal Biomass, 2015 Regional Comparison (mg/kg) .. 66 Figure 33. Quantities of Antimicrobial Agents Intended for Use in Animals Adjusted by Animal Biomass, Updated 2014 Regional Comparison (mg/kg) .. 67 Figure A1. Country Barriers to Reporting Quantitative Data on Antimicrobial Agents Intended for Use in Animals in 11 Countries in Africa During the Third Round of Data Collection.