www.SurePath.com SurePath changing for the better.

1 Now You re Sure. 1 Bigras G et al. Keeping collecting device in liquid medium is mandatory to ensure optimized liquid-based cervical cytology sampling. Journal of Lower Genital Tract Disease, Vol. 7(3), 2003: 168-174. 2 ACOG Practice Bulletin, No. 45, August 2003. Clinical Management Guidelines for Cervical Cytology Screening. 3 American Cancer Society. Early Detection of Cervical Cancer. Nov/Dec 2002, Vol. 52(6). 4 Compared to conventional Pap smear. See PrepStain package insert, Direct-to-Vial study population, Table 26 for these clinical sites and these study populations. Note: Site to site variations in performance are laboratory must carefully monitor the quality of its PrepStain System produces SurePath slides that are intended as replacements for conventional gynecological Pap smears. SurePath slides are intended for use in the screening and detection of cervical cancer, pre-cancerous lesions, atypical cells and all other cytologic categories as defined by The BethesdaSystem for Reporting Cervical/Vaginal Cytologic Diagnoses.

2 Specimens should be collected using a broom-type or combination brush/plastic spatula sampling device(s). Please refer to applicable package insert for a complete list of indications for use, training requirements, limitations, warnings, and unique collection device(s) all have detachableheads so you get more of the sample everytime1. Since the heads of these devices are detached and deposited into the vial, 100% of the collected sample can be sent to the lab for processing. Alternately a rinse and swirl technique canresult in discarding up to 37% of the samplecollected during cell transfer1, which couldmean the difference between finding anabnormality and missing it. Today, with ACOG2and ACS3recommenda-tions for longer cervical cancer screeningintervals, you can t afford to put your patientsor your practice at risk by discarding any ofthe sample using a rinse and swirl technique.

3 Think about what SurePath unique samplecollection could mean to her. Protect herand your practice. Choose SurePath .I WANT SurePath . SurePath is easy to use:stepstepstepSurePath is the only Pap test available today witha increase in HSIL+ the cytology sampleusing either a broom-likedevice or combinationbrush/plastic spatula withdetachable heads. Followmanufacturer s collectioninstructions for detachablehead device(s).Drop the detachable head device(s) into theSurePath the cap on the vial andtighten. Send the SurePath vial to the lab for SendSurePath technology ischangingcervical cancer screeningfor the Free: 1-866-TriPath TriPath Imaging , Inc., 780 Plantation Drive, Burlington, NC SurePath offers severalcollection device : Do Not Use Cytobrush Plus GT on pregnant patients or for endometrial SurePath Sample Collection Kit product insert for complete Directions for : The Cervex-Brush should not be usedon patients after the first 10 weeks of Rovers Cervex-Brush product insert for complete Directions for Use.

4 6 See SurePath Sample Collection Kit product insert for complete Directions for Use. Cervex-Brush is a product and registered trademark of Rovers , Oss, The Path Sample Collection Kit is manufactured by Medscand, a Cooper Surgical Company, Trumbull, 1 SurePath Sample Collection with Broom-Type Device withDetachable Head53. SendDrop the detachable head of the device into the SurePath the cap on the vial and tighten. Send the SurePath vial to the lab for the Rovers Cervix-Brush into the endocervical brush five times in a clockwise 2 SurePath Sample Collection with Combination Brush/plasticSpatula Device with Detachable Heads61A. NextInsert the contoured end of the Pap Perfect plastic spatula androtate 360oaround theentire the device handleand drop the detachablehead of the device into the SurePath vial.

5 Place cap on vial; do not tighten cap until Step #3B Send. Go to Cytobrush Plus GT Step #1B. Collect. 1B. SendInsert Cytobrush Plus GTinto the endocervix untilonly the bottom-most bris-tles are exposed at the rotate 1/4 to 1/2 turnin one direction. To reduceunnecessary bleeding, donot over-rotate brush. Snap the device handleand drop the detachablehead of the device into the SurePath vial. Place the cap on the vialand tighten. Send theSurePath vial to the labfor Methods to Detach Heads of Collection Devices:Two-Hand SNAP 6Do not touch the head of the device while You re Sure. Care must be taken to avoid splashing and/or contaminationof the head(s) of the device(s).PA# 980-05666-00 Rev C 10/04 2004 TriPath Imaging , Rights Methods to Detach Heads of Collection Devices:Cap-assisted SNAP 6