化妆品卫生规范 - yakujihou.com

1 Hygienic Standard for Cosmetics I 1 ..12 .. 13 .. 14 .. 15 .. 2 2 1 ..3 2 2 ..56 3 INCI ..59 4 INCI ..70 5 INCI ..75 6 .. 77 7 INCI ..90 ..95 ..96 ..99 / ..102 / ..106 ..110 ..115 / ..118 ..125 ..129 ..133 .. 136 .. 140 II.

2 143 ..147 ..151 / ..154 ..159 ..161 ..166 ..174 ..180 .. 183 ..187 ..192 ..197 ..199 ..202 ..204 ..207 ..210 ..215 ..220 ..228 ..234 ..237 ..239 ..241 - ..243 ..249 ..252 D2 III ..256 UVA ..258 ..260 ..262 ..265 ..268 ..271 ..274 ..276 ..277 ..280 ..282 SPF ..283 ..287 PFA ..289 General Principle 11 2 , 76 768 EEC 2005 11 21 (The Cosmetics Directive of the Council European Communities, 76 768 EEC, and amendments until 21 November 2005) 3 , , 4 , 2(1) 2(2)

3 3 , , 4 , , 5 , , 6 , , 7 , , , , 500 CFU mL 500 CFU g 1000 CFU mL 1000 CFU g 100 CFU mL 100 CFU g 1 1 mg/kg 1 40 10 2000 5

4 3 2(1) (1)(2) ( ) 1 , , - , , -Trichlorotoluene (CAS No 98-07-7) 2 , - , -Dichlorotoluene (CAS No 98-87-3) 3 - -Chlorotoluene (CAS No100-44-7) 4 1-(1- ) 1-(1-Naphthylmethyl) quinolinium (CAS No 65322-65-8) 5 1-(4- )-4,4- -3-(1,2,4- -1- ) -3- 1-(4-Chlorophenyl)-4,4-dimethyl-3-(1,2,4 -triazol-1-ylmethyl)pentan-3-ol(CAS No 107534-96-3) 6 1-(4- )-1- -3- 1-(4-Methoxyphenyl)-1-penten-3-one (CAS No 104-27-8) 7 1,1,2- 1,1,2-Trichloroethane (CAS No 79-00-5) 8 1,1,3,3,5- -4,6- ( ) 1,1,3,3,5-Pentamethyl-4,6-dinitroindane (moskene) 9 [(1,1 - )-4,4 - ] [(1,1 -Biphenyl)-4,4 -diyl]diammonium sulphate (CAS No 531-86-2) 10 [1,1- ( )] ( , ) 1,1-Bis(dimethylaminomethyl)propyl benzoate (amydricaine, alypine) and its salts 11 1,2,3,4,5,6- , 1,2,3,4,5,6-Hexachlorcyclohexanes with the exception of those specified elsewhere in this Annex 12 1,2,3- 1,2,3-Trichloropropane (CAS No 96-18-4) 13 1,2,4- 1,2,4-Triazole (CAS No 288-88-0) 14 1,2- C7-11 1,2-Benzenedicarboxylic acid di-C7-11, branched and linear alkylesters (CAS No 68515-42-4) 15 1,2- 1,2-Benzenedicarboxylic acid, dipentylester, branched and linear(CAS No 84777-06-0)

5 N-Pentyl-isopentylphthalate Di-n-pentyl phthalate (CAS No 131-18-0) Diisopentylphthalate (CAS No 605-50-5) 16 1,2- (2- ) 1,2-Bis(2-methoxyethoxy)ethane triethylene glycol dimethyl ether (CAS No 112-49-2) 17 1,2- -3- 1,2-Dibromo-3-chloropropane (CAS No 96-12-8) 18 1,2- 1,2-Dibromoethane (CAS No 106-93-4) 19 1,2- -3- 1,2-Epoxy-3-phenoxypropane (CAS No 122-60-1) 20 1,2- 1,2-Epoxybutane 21 1,3,5- ( )-1,3,5- -2,4,6(1H,3H,5H) 1,3,5-Tris(oxiranylmethyl)-1,3,5-triazin e-2,4,6(1H,3H,5H)-trione (CAS No 2451-62-9) 22 1,3,5- -[(2S 2R)-2,3- ]-1,3,5 -2,4,6-(1H,3H,5H)- 1,3,5-Tris-[(2S and 2R)-2,3-Epoxypropyl]-1,3,5-triazine-2,4, 6-(1H,3H,5H)-trione (CAS No 59653-74-6) 23 1,3- ( )- 1,3-Bis(vinylsulfonylacetamido)-propane (CAS No 93629-90-4) 24 1,3- -2- 1,3-Dichloropropan-2-ol (CAS No 96-23-1) 4 25 1,3- 1,3-Dimethylpentylamine and its salts 26 1,3- 1,3-Diphenylguanidine (CAS No 102-06-7) 27 1,3- 1,3-Propanesultone (CAS No 1120-71-4) 28 1,4,5,8- ( 1) 1,4,5,8-Tetraaminoanthraquinone (Disperse Blue 1) (CAS No 2475-45-8) 29 1,4- ( - ) 1,4-Dichlorobenzene(p-dichlorobenzene) (CAS No 106-46-7) 30 1,4- -2- 1,4-Dichlorobut-2-ene (CAS No 764-41-0) 31 11- - ( )

6 -4- -3,20- , 11-Alpha-hydroxypregn-4-ene-3,20-dione and its esters 32 1- 2- 1-and 2-Naphthylamines and their salts 33 1- -3,4,5- 1-Bromo-3,4,5-trifluorobenzene (CAS No 138526-69-9) 34 1- ( ) 1-Bromopropane(n-propyl bromide) (CAS No 106-94-5) 35 1- -3-(N- ) 1-Butyl-3-(N-crotonoylsulphanilyl)urea 36 1- -2,3- 1-Chloro-2,3-epoxypropane (CAS No 106-89-8) 37 1- -4- 1-Chloro-4-nitrobenzene (CAS No 100-00-5) 38 1- -1- ( ) 1-Dimethylaminomethyl-1-methylpropyl benzoate (amylocaine) and its salts 39 1- -1- 1-Ethyl-1-methylmorpholinium bromide (CAS No 65756-41-4) 40 1- -1- ( ) 1-Ethyl-1-methylpyrrolidinium bromide (CAS No 69227-51-6) 41 1- -2,4- (2,4- -CI76050) 1-Methoxy-2,4-diaminobenzene (2,4-diaminoanisole-CI 76050) and their salts 42 1- -2,5- (2,5- ) 1-Methoxy-2,5-diaminobenzene (2,5-diaminoanisole) and their salts 43 1- -3- -1- 1-Methyl-3-nitro-1-nitrosoguanidine (CAS No 70-25-7) 44 ( 3 ) (1R,2S)-Hexahydro-1,2-dimethyl-3,6-epoxy phthalic anhydride (cantharidin), with the exception of cantharides tincture listed in table 3 45 (1R,4S,5R,8S)-1,2,3,4,10,10-Hexachloro-1 ,4,4a,5,8,8a-hexahydro-1,4:5,8-dimethano - naphthalene (isodrin-ISO) 46 (1R,4S,5R,8S)-1,2,3,4,10,10-Hexachloro-6 ,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-1,4 .

7 5,8-dimethano-naphthalene (endrin-ISO) 47 1- -2- 1-Vinyl-2-pyrrolidone (CAS No 88-12-0) 48 2-(2-(4-Chlorophenyl)-2-phenylacetyl) indan 1,3-dione (chlorophacinone-ISO) 49 (+/-)-2-(2,4- )-3-(1H-1,2,4- -1- ) -1,1,2,2- (+/-)-2-(2,4-Dichlorophenyl)-3-(1H-1,2,4 -triazol-1-yl)propyl-1,1,2,2-tetrafluoro ethylether (CAS No 112281-77-3) 50 2-(2- ) 2-(2-Methoxyethoxy)ethanol (CAS No 111-77-3) 5 51 2-(4- -2- )-N,N- 2-(4-Allyl-2-methoxyphenoxy)-N,N-diethyl acetamide and its salts 52 2-(4- - ) 2-(4-tert-Butylphenyl)ethanol (CAS No 5406-86-0) 53 2,2,2- 2,2,2-Tribromoethanol (tribromoethyl alcohol) 54 2,2,2- -1,1- 2,2,2-Trichloroethane-1,1-diol 55 2,2,6- -4- ( ) 2,2,6-Trimethyl-4-piperidyl benzoate (benzamine) and its salts 56 2,2 -( ) 2,2 -(Nitrosoimino)bisethanol (CAS No 1116-54-7) 57 2,2- 2,2 -Bioxirane (CAS No 1464-53-5) 58 2,2 - -3,3',5,5',6,6'- ( ) 2,2 -Dihydroxy-3,3 ,5,5 ,6,6 -hexachlorodiphenylmethane (hexachlorophene) 59 2,2- -2- 2,2-Dibromo-2-nitroethanol (CAS No 69094-18-4) 60 2,3,4- -1- 2,3,4-Trichlorobut-1-ene (CAS No 2431-50-7) 61 2,3,7,8- - - 2,3,7,8-Tetrachlorodibenzo-p-dioxin 62 2,3- -1- 2,3-Dibromopropan-1-ol (CAS No 96-13-9) 63 2,3- -2- 2,3-Dichloro-2-methylbutane 64 2,3- 2,3-Dichloropropene (CAS No 78-88-6)

8 65 2,3- 2,3-Dinitrotoluene (CAS No 602-01-7) 66 2,3- -1- 2,3-Epoxypropan-1-ol (CAS No 556-52-5) 67 2,3- . - 2,3-Epoxypropyl o-tolyl ether (CAS No 2210-79-9) 68 2,4,5- 2,4,5- 2,4,5-Trimethylaniline (CAS No 137-17-7) 2,4,5-Trimethylaniline hydrochloride (CAS No 21436-97-5) 69 2,4,6- 2,4,6-Trichlorophenol (CAS No 88-06-2) 70 2,4- 2,4-Diaminophenylethanol and its salts 71 2,4- -3- 2,4-Dihydroxy-3-methylbenzaldehyde (CAS No 6248-20-0) 72 2,5- 2,5-Dinitrotoluene (CAS No 619-15-8) 73 2,6- -4- 2,6-Dibromo-4-cyanophenyl octanoate (CAS No 1689-99-2) 74 (2,6- -1,3- -4- ) 2,6-Dimethyl-1,3-dioxan-4-yl acetate (dimethoxane) 75 2,6- 2,6-Dinitrotoluene (CAS No 606-20-2) 76 2-[2- -3-(2- ) -1- ]-7-[2- -3-(3- )-2-[2- -3-(3- )- -1- ]-7-[2- -3-(3- )]]

9 - -1- ] -9- 2-[2-Hydroxy-3-(2-chlorophenyl)carbamoyl -1-naphthylazo]-7-[2-hydroxy-3- (3-methylphenyl) -2-[2-hydroxy-3-(3-methylphenyl)-carbamo yl-1-naphthylazo]-7-[2-hydroxy-3-(3-meth ylphenyl) -carbamoyl-1-naphthylazo]fluoren-9-one(E C No 420-580-2) 6 77 2-(4- -N-(2- ) ) 2-[4-Methoxybenzyl-N-(2-pyridyl) amino] ethyldimethylamine maleate 78 2-{4-(2- )-6-[4- -3-(5- -2- -4- )-2- -7- ]-1,3,5- }-2- 2-{4-(2-Ammonio propylamino)-6-[4-hydroxy-3-(5-methyl-2- methoxy-4-sulfamoylphenylazo)-2 -sulfonatonaphth-7-ylamino]-1,3,5-triazi n-2-ylamino}-2-aminopropyl formate(EC No 424-260-3) 79 2-Acetoxyethyltrimethylammonium hydroxide (acetylcholine )and its salts 80 2- - (N,N,N',N - ) 2-Alpha-cyclohexylbenzyl (N,N,N',N -tetraethyl) trimethylenediamine (phenetamine) 81 2- -1,2- (4- ) 2-Amino-1,2-bis(4-methoxyphenyl)ethanol and its salts 82 2- -4- 2-Amino-4-nitrophenol 83 2- -5- 2-Amino-5-nitrophenol 84 2- 2-Bromopropane (CAS No 75-26-3) 85 2- 2-Butanone oxime (CAS No 96-29-7) 86 2- -6- -4- ( ) 2-Chloro-6-methylpyrimidin-4-yldimethyla mine (crimidine-ISO) 87 3- -4- -2- 2-Diethylaminoethyl 3-hydroxy-4-phenylbenzoate and its salts 88 2- 2-Ethoxyethanol (CAS No110-80-5) 89 2- 2-Ethoxyethyl acetate (CAS No 111-15-9) 90 2- 2-Ethylhexanoic acid (CAS No 149-57-5)

10 91 2- [[[3,5- (1,1- )-4- ]- ]- ] 2-Ethylhexyl[[[3,5-bis(1,1-dimethylethyl )-4-hydroxyphenyl]-methyl]thio]acetate (CAS No 80387-97-9) 92 (2- -4- ) (2-Isopropylpent-4-enoyl) urea (apronalide) 93 2- 2-Methoxy