Isosteresin Medicinal Chemistry Group Meeting Christos ...

lipophilicity Peptide surrogates Peptides are characterized by diminished bioavailability when administered orally. Replacement of the sensitive amide bond by various groups can increase their stability. O O O H N R2 R 1 N-alkylation N O O H N R2 R R N H O N O H N R2 R1 Azapeptide N H O O H N R2 R1 Dehydroaminoacid N H S O H N R R Thioamide N H ...

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